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Preparation method of 2-methylthieno [2,3-d]thiazole

A technology of methylthiophene and 3-d, which is applied in the field of compound preparation, can solve the problems of high cost, complicated method, and low yield of prepared products, and achieve the effects of mild reaction, high product purity, and easy control

Inactive Publication Date: 2019-10-25
SUZHOU RYAN PHARMACHEM TECH CO LTD
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AI Technical Summary

Problems solved by technology

[0002] The method for preparing 2-methylthieno[2,3-d]thiazole by traditional technology is complicated, the cost is high, and the yield of the prepared product is low

Method used

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  • Preparation method of 2-methylthieno [2,3-d]thiazole

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Embodiment Construction

[0022] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings and preferred embodiments.

[0023] As shown in the figure, the present invention includes the following steps

[0024] a. Preparation of S-22A

[0025] Add the compound shown in Formula A and 60kg of acetic anhydride into a 100L reaction bottle, stir, freeze and cool down to 15°C, and start to add 10.7kg of concentrated nitric acid dropwise. After keeping warm for 1 hour, take a sample for TLC (PE:EA=6:1), the raw materials have been reacted, put them into 300L water, stir for 1 hour, and filter to obtain a wet product: 19kg.

[0026] Dissolve the wet product in 40kg of ethyl acetate, dry with anhydrous sodium sulfate, filter, concentrate the organic phase under reduced pressure to a small amount of solvent, pour it into 40L of petroleum ether whi...

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Abstract

The invention relates to the field of preparation methods of compounds, in particular to a preparation method of 2-methylthieno[2,3-d]thiazole. Reaction is performed by using a compound represented byformula A as a raw material, and the product prepared by the preparation method has high purity, a catalyst and a solvent can be recycled, the reaction is mild, and the preparation method of the 2-methylthieno[2,3-d]thiazole is easy to control and suitable for industrial production.

Description

technical field [0001] The invention relates to the field of compound preparation methods, in particular to a preparation method of 2-methylthieno[2,3-d]thiazole. Background technique [0002] The traditional method for preparing 2-methylthieno[2,3-d]thiazole is complicated, high in cost and low in yield. Contents of the invention [0003] The technical problem to be solved by the present invention is to overcome the deficiencies in the prior art and provide a preparation method of 2-methylthieno[2,3-d]thiazole [0004] The present invention is achieved through the following technical solutions: [0005] A kind of preparation method of 2-methylthieno[2,3-d]thiazole is characterized in that, comprises the following steps: [0006] a. compound shown in the preparation formula S-22A: [0007] Add the compound shown in Formula A and acetic anhydride into the reaction flask, stir, cool down to 15°C, add concentrated nitric acid dropwise, keep warm at 15°C for 1 hour, take a ...

Claims

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Application Information

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IPC IPC(8): C07D513/04
CPCC07D513/04Y02P20/584
Inventor 夏青青江涛张明张路路
Owner SUZHOU RYAN PHARMACHEM TECH CO LTD
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