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Method for detecting the quality of angelica

A detection method, the technology of Angelica, applied in the direction of measuring devices, instruments, scientific instruments, etc., to achieve the effect of ensuring safety and effectiveness, and good scientific data support

Active Publication Date: 2021-10-01
SHAANXI UNIV OF CHINESE MEDICINE
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  • Description
  • Claims
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Problems solved by technology

[0007] The purpose of the present invention is to provide a method for evaluating the quality markers of Angelica sinensis based on the research idea of ​​"substance-effect", and then overcome the technical problem that only a single component evaluates the quality of Angelica sinensis in practice

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  • Method for detecting the quality of angelica
  • Method for detecting the quality of angelica
  • Method for detecting the quality of angelica

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Experimental program
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Effect test

Embodiment 1

[0038] Embodiment a kind of angelica quality detection method

[0039] (1) Sample preparation: With reference to the "Preparation of the test solution" method under the "Angelica" content determination item of "Chinese Pharmacopoeia" 2015 edition, about 0.2g of Angelica powder (passed through a No. 3 sieve) was weighed, accurately weighed, Place in a Erlenmeyer flask, accurately add 20mL of 70% methanol, weigh it, reflux in a water bath at 85°C for 30 minutes, let it stand to cool, weigh it, add solvent to make up for the reduced weight, shake it evenly, let it stand, and take the supernatant to filter , take the filtrate for subsequent use.

[0040] (2) Fingerprint determination and composition characterization:

[0041] The data were collected by liquid chromatography-mass spectrometry, and the spectrum data obtained by UPLC / Q-TOF-MS analysis and detection were imported into the spectrum processing software to identify the compounds. Through the comparison, analysis and sc...

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Abstract

The invention discloses a method for detecting the quality of Angelica sinensis. With reference to the screening criteria of pharmacokinetic parameters such as lipid-water partition coefficient, oral bioavailability, and druggability of each matching compound, the secondary screening has excellent pharmacokinetics and high safety. These compounds are regarded as "pharmaceutical ingredient groups" related to the efficacy of Angelica sinensis. Then, according to the "substance-efficacy" interaction relationship of Angelica sinensis, the measured in vitro / in vivo biological activity of Angelica sinensis is used as the monitoring factor Y, and the "drug effect component group" of Angelica sinensis is used as the observation factor X, and the biological activity and "drug effect component group" of Angelica sinensis are established. "Partial least squares regression model to find components that are positively correlated with the biological activity of Angelica sinensis and have a high correlation coefficient, and these components are used as "quality markers" for the quality evaluation of Angelica sinensis. Finally, the content determination method of "quality markers" of Angelica sinensis was established by liquid chromatography-mass spectrometry, which provides an industrialization path for the overall quality traceability and control of Angelica sinensis medicinal materials or decoction pieces.

Description

technical field [0001] The invention relates to a detection method for the quality of angelica, in particular to a detection method for quality evaluation of angelica based on a "substance-effect" research idea, and belongs to the technical field of drug detection. Background technique [0002] As the basic raw materials for the production of Chinese medicinal materials and Chinese patent medicines, the quality of Chinese medicinal materials is the key and fundamental to ensure the quality of Chinese medicinal materials and Chinese patent medicines, and the standardization of Chinese medicinal materials is an important measure to ensure the quality of Chinese medicinal materials. premise. [0003] Angelica sinensis is the dried root of Angelica sinensis (Oliv.) Diels, a 2-year-old herb of the Umbelliferae family. The medicinal records first appeared in "Shen Nong's Herbal Classic", which has a history of more than 2,000 years. Angelica has a strong aroma, sweet, pungent, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/86G01N30/72G01N30/06
CPCG01N30/02G01N30/06G01N30/72G01N30/8631G01N30/8686G01N2030/027G01N2030/047
Inventor 唐志书刘妍如宋忠兴江大海李晓红杨宁娟
Owner SHAANXI UNIV OF CHINESE MEDICINE
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