Solubilizing BODIPY photosensitizer and preparation method and application thereof in preparing medicine for treating body surface diseases

A photosensitizer and body surface technology, which is applied in the field of medicine and medical treatment, can solve the problems of complex synthesis methods, high cost, and toxicity, and achieve the effects of high extinction coefficient, low production cost, and good dispersibility
CN110407864AActive Publication Date: 2019-11-05ๆ™ฏ้ๆ–Œ
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
ๆ™ฏ้ๆ–Œ
Publication Date
2019-11-05

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Abstract

The invention provides a solubilizing BODIPY photosensitizer and a preparation method and application thereof in preparing medicine for treating body surface diseases, and belongs to the field of medicine and medical methods. The photosensitizer is obtained by dissolving fat-soluble BODIPY or aza-BODIPY in an organic solvent and achieving solubilization by conversion from an organic solution to awater system. The preparation method of the solubilizing BODIPY photosensitizer and the application of the solubilizing BODIPY photosensitizer in preparing the medicine for treating the body surface diseases are also provided. The BODIPY photosensitizer prepared by the preparation method can be applied at a lower drug concentration and dosage, the light intensity required for photoexcitation is about 10-100 mW / cm<2>, the illumination time is 10-30 minutes, the total excitation energy is about 10-180 J / cm<2>, and the tolerance and compliance of patients are significantly improved.
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Description

technical field

[0001] The invention belongs to the field of medicine and medical treatment methods, and in particular relates to a solubilized BODIPY photosensitizer, a preparation method and an application in preparation of medicines for treating body surface diseases. Background technique

[0002] The principle of photodynamic therapy for the treatment of microbial infections on the body surface is to apply a photosensitizer to the infected area, that is, the area where the pathogenic microorganisms are located, and then irradiate the area with light of an appropriate wavelength. The photosensitizer directly interacts with the substrate / solvent under the excitation of light to generate oxygen-containing free radicals (type I reaction), or generate singlet oxygen (type II reaction). These active oxygen components such as oxygen-containing free radicals and singlet oxygen lead to the death of pathogenic microorganisms through lipid peroxidation, membrane damage and organell...

Claims

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