Inhaling-type preparation anti-pollution negative-pressure administration chamber

Abstract

The invention provides an inhaling-type preparation anti-pollution negative-pressure administration chamber. The inhaling-type preparation anti-pollution negative-pressure administration chamber comprises an administration chamber body, two sets of air purification systems, two sets of laminar flow forming areas and an administration area, the two sets of laminar flow forming areas are arranged atthe two ends of the administration chamber body correspondingly, and the administration area is arranged between the two sets of laminar flow forming areas; airflow is blown out from one set of laminar flow forming area, passes through the administration area and then is blown out from the other set of laminar flow forming area to form unidirectional airflow in the administration area; and heating temperature-regulating plates and refrigerating temperature-regulating plates are arranged in the two sets of laminar flow forming areas correspondingly. Through arrangement of the two sets of laminar flow forming areas, the purpose of providing the pure unidirectional airflow in the administration chamber is realized; by arranging matrix-type air-blowing structures composed of a plurality of laminar flow units in the two sets of laminar flow forming areas, the environment with different laminar flow speeds and different temperature requirements is realized; and by forming a pressure bufferchamber, the adaptability of the body of an experimenter to the negative pressure is avoided, and meanwhile, the pressure buffer chamber is mutually matched with the two sets of laminar flow forming areas to realize the constant pressure of the administration chamber.

Description

technical field [0001] The invention relates to the technical field of drug delivery environment for clinical trials of medicine, in particular to an inhalation-type anti-pollution negative pressure drug delivery room for preparations. Background technique [0002] When conducting pharmacokinetic or bioequivalence studies on inhaled new drugs, a certain number of subjects need to be administered. Due to the special administration method of inhaled preparations, after administration, some drugs will remain in the In the air, the drugs remaining in the air will cause cross-contamination after being inhaled by other test subjects, resulting in inaccurate research results; at the same time, the nasal spray in the inhaled drugs has requirements for the temperature and humidity of the environment during administration. Higher, the fluctuation of temperature and humidity can greatly affect the absorption of the liquid medicine by the nasal mucosa of the subject. [0003] Therefore...

AI Technical Summary

Problems solved by technology

[0002] When conducting pharmacokinetic or bioequivalence studies on inhaled new drugs, a certain number of subjects need to be administered. Due to the special administration method of inhaled preparations, after administration, some drugs will remain in the In the air, the drugs remaining in the air will cause cross-contamination after being inhaled by other test subjects, resulting in inaccurate research results; at the same time, the nasal spray in the inhaled drugs has requirements for the temperature and humidity of the environment during administration. Higher, fluctuations in temperature and humidity can greatly affect the absorption of medicinal liquid by the nasal mucosa of the subject

[0003] Therefore, a negative pressure dosing room is generally needed to solve the above problems, but although the existing negative pressure dosing room can provide a negative pressure environment, it cannot provide a pure unidirectional airflow, so the risk of cross-infection of drugs by experimenters cannot be avoided; at the same time The negative pressure dosing room should be able to provide a stable environment with adjustable temperature and humidity to meet different drug experiments

Images