An anti-pollution negative pressure dosing room for inhalation preparations

Abstract

The invention provides an inhalation-type anti-pollution negative pressure dosing room for preparations, which includes a dosing room, two sets of air purification systems, two sets of laminar flow forming areas, and a dosing area, and the two sets of laminar flow forming areas are respectively arranged in the dosing room At both ends, the drug administration area is set in the middle of the two sets of laminar flow forming areas; the air flow is blown out from one set of laminar flow forming areas, passes through the drug administration area, and then blows out from the other set of laminar flow forming areas, forming a single direction in the drug administration area Air flow; two sets of laminar flow forming areas are respectively provided with a heating and cooling temperature regulating plate. The present invention achieves the purpose of providing a pure single-directional airflow in the drug delivery chamber through the setting of two sets of laminar flow forming areas; and realizes The environment with different laminar flow velocities and different temperature requirements can be avoided; by setting up a pressure buffer chamber, the ability of the human body to adapt to negative pressure can be avoided, and at the same time cooperate with two sets of laminar flow forming areas to achieve a constant pressure in the dosing chamber.

Description

technical field [0001] The invention relates to the technical field of drug delivery environment for clinical trials of medicine, in particular to an inhalation-type anti-pollution negative pressure drug delivery room for preparations. Background technique [0002] When conducting pharmacokinetic or bioequivalence studies on inhaled new drugs, a certain number of subjects need to be administered. Due to the special administration method of inhaled preparations, after administration, some drugs will remain in the In the air, the drugs remaining in the air will cause cross-contamination after being inhaled by other test subjects, resulting in inaccurate research results; at the same time, the nasal spray in the inhaled drugs has requirements for the temperature and humidity of the environment during administration. Higher, the fluctuation of temperature and humidity can greatly affect the absorption of the liquid medicine by the nasal mucosa of the subject. [0003] Therefore...

AI Technical Summary

Problems solved by technology

[0002] When conducting pharmacokinetic or bioequivalence studies on inhaled new drugs, a certain number of subjects need to be administered. Due to the special administration method of inhaled preparations, after administration, some drugs will remain in the In the air, the drugs remaining in the air will cause cross-contamination after being inhaled by other test subjects, resulting in inaccurate research results; at the same time, the nasal spray in the inhaled drugs has requirements for the temperature and humidity of the environment during administration. Higher, fluctuations in temperature and humidity can greatly affect the absorption of medicinal liquid by the nasal mucosa of the subject

[0003] Therefore, a negative pressure dosing room is generally needed to solve the above problems, but although the existing negative pressure dosing room can provide a negative pressure environment, it cannot provide a pure unidirectional airflow, so the risk of cross-infection of drugs by experimenters cannot be avoided; at the same time The negative pressure dosing room should be able to provide a stable environment with adjustable temperature and humidity to meet different drug experiments

Images