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Composition with function of relieving diarrhea and preparing method and application thereof

A composition and polymer technology, applied in the field of biomedicine, can solve the problems of many contraindications, inability to take for a long time, fast gastric emptying, etc., to prevent and treat alternating symptoms of diarrhea and constipation, reduce watery diarrhea, and promote reabsorption. Effect

Active Publication Date: 2019-11-15
麦孚营养科技(北京)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, montmorillonite is a natural clay composed of aluminum hydroxide-magnesium carbonate bisilicate. It cannot be taken for a long time, otherwise it will easily lead to constipation and dry stool.
[0022] In summary, the antidiarrheal products disclosed in the prior art have many defects: (1) limited indications, many application contraindications, limited applicable population and application methods, especially not suitable for patients with tumor-associated diarrhea; (2) complex ingredients , the preparation process is complicated and the cost is high; (3) the gastric emptying speed is too fast, which is not conducive to the stability of blood sugar; (4) it is not easy to absorb, the side effects are obvious, and it cannot be taken for a long time, etc.

Method used

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  • Composition with function of relieving diarrhea and preparing method and application thereof
  • Composition with function of relieving diarrhea and preparing method and application thereof
  • Composition with function of relieving diarrhea and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] Example 1 Preparation of compositions 1-4 of the present invention

[0129] The components and proportions of compositions 1-4 of the present invention are shown in Table 2.

[0130] Table 2

[0131]

[0132]

[0133] The preparation method of the composition 1-4 of the present invention: take the ingredients listed in Table 2 respectively, put them into a mixer and mix them uniformly, and control the environmental humidity to ≤65%; put the mixed materials into a packaging machine, and use aluminum Divide into plastic bags, seal them, and seal them in 10g bags.

[0134] Compositions 1-4 were compared with the indicators specified in GB 29922-2013 one by one, and it was found that compositions 1-4 all met the requirements.

Embodiment 2

[0135] Example 2 Sensory evaluation experiment of the composition of the present invention

[0136] 1. Sensory evaluation volunteers

[0137] A total of 180 subjects with diarrhea symptoms were selected, including patients with diarrhea caused by six causes, of which, 30 cases were patients with tumor radiotherapy-related diarrhea, 30 cases were patients with ulcerative colitis diarrhea, and 30 cases were patients with irritable bowel syndrome diarrhea Among the patients, 30 cases were patients with chronic diarrhea, 30 cases were patients with persistent diarrhea, and 30 cases were patients with diabetic diarrhea. Among them, the age of persistent diarrhea patients is 1-2.5 years old, and other diarrhea patients are 30-70 years old.

[0138] 180 subjects took the composition 1 of the present invention. Among them, the dosage for adults is 2-3 times / day, and the dosage for children is 1-2 times / day, 10g / time. Take it with 120ml of warm boiled water for 7 consecutive days....

Embodiment 3

[0144] Example 3 Study on the prevention and treatment effect of the composition of the present invention on tumor radiotherapy diarrhea

[0145] 1. Experimental samples

[0146] A total of 96 patients with colorectal cancer were selected as subjects. The subjects underwent radical resection of colorectal cancer and radiotherapy, and were divided into control group and experimental group according to the random allocation scheme, with 48 cases in each group.

[0147] In the control group, there were 30 male patients and 18 female patients, aged 30-65 years. Disease types included 27 patients with rectal cancer and 21 patients with colon cancer. TNM staging included 28 patients with stage II, 14 patients with stage III, and 6 patients with stage IV.

[0148] In the experimental group, there were 32 male patients and 16 female patients, aged 32-66 years. Disease types included 26 patients with rectal cancer and 22 patients with colon cancer. TNM staging included 26 patient...

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PUM

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Abstract

The invention provides a composition with the function of relieving diarrhea and a preparing method and application thereof. The composition contains macromolecule glue and a polymer, and is suitablefor tumor-associated diarrhea, antibiotic-and-drug therapeutic diarrhea, intestinal inflammation disease diarrhea, diabetic diarrhea, irritable bowel syndrome diarrhea, persistent diarrhea, chronic diarrhea, viral or bacterial infection diarrhea, and enteral nutrition intolerance diarrhea and alternating diarrhea and constipation of critically-ill patients. The composition can be applied to patients through nasal feeding and oral administration, can be used for both children and adults, has two-way regulation effects on diarrhea and constipation, and can be taken for a long term.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a composition with antidiarrheal effect, a preparation method thereof and an application thereof. Background technique [0002] Diarrhea, commonly known as "diarrhea", refers to the frequency of defecation significantly exceeding the usual habit, and the fecal matter is thin, the water is increased, the daily defecation volume exceeds 200g, or the excreted feces contain undigested food, even pus, blood and mucus Wait. A normal person’s daily gastrointestinal fluid intake is about 9L, water is absorbed through the intestine, and the water content in feces is only about 100-200ml. If the amount of fluid entering the colon exceeds the absorptive capacity of the colon or (and) the absorptive capacity of the colon decreases, it will lead to increased excretion of water in the feces and diarrhea. Diarrhea can reduce the body's resistance, cause problems such as malnutrition, anemia and vit...

Claims

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Application Information

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IPC IPC(8): A61K31/732A61K31/702A61K31/715A61K31/733A61K31/7016A61P1/12A61P1/04A61P1/00A61P31/04A61P31/12A61P29/00A61P35/00A61P3/10
CPCA61K31/7016A61K31/702A61K31/715A61K31/732A61K31/733A61P1/00A61P1/04A61P1/12A61P3/10A61P29/00A61P31/04A61P31/12A61P35/00A61K2300/00
Inventor 郭伟
Owner 麦孚营养科技(北京)有限公司
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