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Application of guaiacol in preparation of medicine for preventing or treating postmenopausal osteoporosis

A technology for osteoporosis, guaiacol, applied in the field of medicine

Pending Publication Date: 2019-11-22
SHANGHAI CHANGHAI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no literature reporting that guaiacol has the effect of inhibiting osteoclastogenesis and treating postmenopausal osteoporosis, nor is there any literature reporting its mechanism of action

Method used

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  • Application of guaiacol in preparation of medicine for preventing or treating postmenopausal osteoporosis
  • Application of guaiacol in preparation of medicine for preventing or treating postmenopausal osteoporosis
  • Application of guaiacol in preparation of medicine for preventing or treating postmenopausal osteoporosis

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Example 1. Guaiacol has inhibitory effect on bone loss after ovariectomy in C57 mice

[0031] 1. Experimental materials:

[0032] The guaiacol was diluted into different concentrations of drug solutions with physiological saline.

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Abstract

The invention relates to the technical field of medicine, in particular to an application of guaiacol in preparing a medicine for preventing or treating postmenopausal osteoporosis, and the structureof the guaiacol is shown as a formula I. The invention provides a new application of guaiacol, and also provides a new thought for prevention and treatment of postmenopausal osteoporosis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of guaiacol in the preparation of drugs for preventing or treating postmenopausal osteoporosis. Background technique [0002] Angelica is a traditional Chinese medicine that has long been used to treat bone diseases including osteoporosis and osteonecrosis. In TCM theory, angelica can increase bone formation and promote fracture healing. Recent studies have shown that Angelica can inhibit RANKL-induced osteoclastogenesis, inhibit osteoporosis and prevent femoral head necrosis. However, its active ingredients and mechanisms remain unclear. We used two-dimensional cell membrane chromatography / monolithic column / time mass spectrometry system to screen the monomers with high affinity to the cell membrane of bone marrow mononuclear cells (BMMCs) in Angelica sinensis, and finally screened guaiacol. [0003] Osteoporosis (OP) is a chronic inflammatory disease characte...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P19/10
CPCA61K31/05A61P19/10
Inventor 智信方超陈辉文孙晨陈晓苏佳灿
Owner SHANGHAI CHANGHAI HOSPITAL