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A kind of composite nanomaterial, its preparation method and application

A composite nanomaterial and gold nanotechnology, applied in the field of materials, can solve the problems of low longitudinal relaxation rate, transverse longitudinal relaxation rate ratio, etc., and achieve the effects of good water dispersibility, excellent MRI relaxation performance, and high crystallinity

Active Publication Date: 2022-04-01
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, common iron oxide nanoparticles are not suitable as MRI T1 contrast agents: MRI T1 contrast agents should have a high longitudinal relaxation rate (r1) and a low transverse-to-longitudinal relaxation rate ratio (r2 / r1≤3) , to highlight the MRI T1 contrast effect (maximized)

Method used

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  • A kind of composite nanomaterial, its preparation method and application
  • A kind of composite nanomaterial, its preparation method and application
  • A kind of composite nanomaterial, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0209] (1) Weigh 0.364g CTAB and dissolve it in 5mL water, place it on a magnetic stirrer, add 0.5mM HAuCl dropwise 4 Solution 5mL, continuously stirred at a speed of 100r / min for 3min, after uniform mixing, under the condition of constant stirring with a magnetic stirrer, quickly drop 10mM NaBH 4 The solution was 0.6mL, the solution changed from light yellow to brownish yellow, after stirring at a speed of 100r / min for 2min, it was collected at 25°C for 2.5h, and solution a was obtained;

[0210] (2) Weigh 0.364g CTAB, dissolve it in 5mL aqueous solution and put it in a beaker, add 4mM AgNO 3 solution 0.2mL, then add 1mM HAuCl 4 Solution 5mL, stirring continuously at 100r / min for 3min, after mixing evenly, add 70μL of 78.8mM ascorbic acid, the solution turns from brown to colorless, and solution b is obtained;

[0211] (3) At room temperature, add 12 μL of solution a to the above solution b, and incubate at 30°C for 12 hours to obtain dark purple mixture c;

[0212] (4) Ad...

Embodiment 2

[0232] (1) Weigh 0.364g CTAB and dissolve it in 5mL water, place it on a magnetic stirrer, add 0.5mM HAuCl dropwise 4 Solution 5mL, continuously stirred at a speed of 80r / min for 3min, after uniform mixing, under the condition of constant stirring with a magnetic stirrer, 0.8mL of 10mM triethanolamine solution was quickly added dropwise, the solution changed from light yellow to brown, and at 800r / min After stirring at a constant speed for 2 minutes, it was collected at 25°C for 2.5 hours to obtain solution a;

[0233] (2) Weigh 0.364g CTAB, dissolve it in 5mL aqueous solution and put it in a beaker, add 4mM AgNO 3 solution 0.2mL, then add 1mM HAuCl 4 Solution 5mL, continuously stirred at a speed of 100r / min for 3min, after mixing evenly, 70μL of 78.8mM ascorbic acid was added, the solution changed from brown to colorless, and solution b was obtained;

[0234] (3) At room temperature, add 12 μL of solution a to the above solution b, and incubate at 30°C for 12 hours to obtai...

Embodiment 3

[0240] (1) Weigh 0.364g CTAB and dissolve it in 5mL water, place it on a magnetic stirrer, add 0.5mM HAuCl dropwise 4 Solution 5mL, continuously stirred at a speed of 80r / min for 3min, after uniform mixing, under the condition of constant stirring with a magnetic stirrer, quickly drop 10mM NaBH 4 Solution 0.5mL, the solution changed from light yellow to brownish yellow, after stirring continuously at 800r / min for 2min, it was collected at 25°C for 2.5h to obtain solution a;

[0241] (2) Weigh 0.364g CTAB dissolved in 5mL aqueous solution and place in a beaker, add 4mM Ag 2 SO 4 solution 0.2mL, then add 1mM HAuCl 4 Solution 5mL, stirring continuously at 100r / min for 3min, after mixing evenly, add 70μL of 78.8mM ascorbic acid, the solution turns from brown to colorless, and solution b is obtained;

[0242] (3) At room temperature, add 12 μL of solution a to the above solution b, and incubate at 30°C for 12 hours to obtain dark purple mixture c;

[0243] (4) Add 6mL of ammoni...

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Abstract

The application discloses a composite nanomaterial, which includes an inner core and an outer layer; the inner core includes gold nanomaterials and magnetic nanomaterials; the outer layer includes hydrophilic materials; and the outer layer wraps the inner core. The composite nanomaterial has good water solubility, low biological toxicity, and excellent crystallization properties, so it has the ability to improve the diagnosis efficiency of major diseases such as tumors and reduce toxic and side effects.

Description

technical field [0001] The application relates to a composite nanomaterial, its preparation method and its application, belonging to the field of materials. Background technique [0002] As the application of medical imaging technology in clinical diagnosis continues to deepen, the research and development of various medical imaging contrast agents related to it is particularly urgent. [0003] Taking magnetic resonance contrast agents as an example, the research on MRI contrast materials at home and abroad is mainly divided into two categories: one is gadolinium-containing coordination compound materials used for T1 contrast, which can increase the signal intensity of tissues on T1-weighted images; The other is superparamagnetic oxide nanomaterials used for T2 / T2* imaging, which can reduce the signal intensity of tissue parenchyma on T2-weighted images. Clinical studies have shown that reagents containing gadolinium have relatively high nephrotoxicity. For example, the Dan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B22F1/17B22F1/054B22F1/102B22F1/145B82Y30/00
CPCB22F9/24B82Y30/00B22F2009/245B22F1/102B22F1/145B22F1/054B22F1/17
Inventor 陈天翔吴爱国马雪华任文智
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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