Nitric oxide donor traditional Chinese medicine compound preparation as well as preparation method and application thereof

A technology of nitric oxide and compound preparations, which is applied in the fields of medical formula, digestive system, drug combination, etc., can solve the problems of drug resistance, short drug effect, hypotension and fainting, and achieve the purpose of enhancing exercise endurance, reducing high blood pressure, Improve the effect of oxygen supply

Active Publication Date: 2019-12-03
郑州恩欧生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these nitric oxide donors are absorbed quickly (once in 1 to 2 minutes), and the drug effect is short (half-life is only 7 minutes), which is likely to cause side effects such as headache, palpitation, hypotension and fainting, and long-term large-scale administration will also cause side effects. drug resistance

Method used

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  • Nitric oxide donor traditional Chinese medicine compound preparation as well as preparation method and application thereof
  • Nitric oxide donor traditional Chinese medicine compound preparation as well as preparation method and application thereof
  • Nitric oxide donor traditional Chinese medicine compound preparation as well as preparation method and application thereof

Examples

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Embodiment 1

[0033] The embodiment of the present invention provides a nitric oxide donor traditional Chinese medicine compound preparation, which includes active raw materials and tablet auxiliary materials, wherein the active raw materials are composed of the following raw materials in parts by mass: 50 parts of Achyranthes bidentata, 30 parts of Danshen, Taizi 5 parts of ginseng, 5 parts of fried Atractylodes macrocephala, 20 parts of Jiangxiang and 1 part of leech.

[0034] This embodiment also provides a preparation method of the above-mentioned Chinese medicine compound preparation, which includes the following steps: according to the above-mentioned parts by mass, mix Achyranthes bidentata and Salvia miltiorrhiza, and add 2 to 3 times the volume of water to the mixture and boil for 30 minutes to 1 hour to obtain the nitric oxide donor plant liquid; add 2 to 3 times the volume of water to boil for 30 minutes to 1 hour, and filter to obtain the Chinese medicine juice; After the nitrog...

Embodiment 2

[0036] The embodiment of the present invention provides a nitric oxide donor traditional Chinese medicine compound preparation, which includes active raw materials and auxiliary materials, wherein the active raw materials are composed of the following raw materials in parts by mass: 60 parts of Achyranthes bidentata, 25 parts of Danshen, and 10 parts of Radix Pseudostellariae 10 parts, 10 parts of fried Atractylodes macrocephala, 20 parts of Jiangxiang and 2 parts of leech, the adjuvant in this embodiment is the adjuvant for capsule preparation.

[0037] This example also provides a preparation method of a nitric oxide donor traditional Chinese medicine compound preparation, which is basically the same as the preparation method provided in Example 1, except that the active dry powder is prepared by mixing the capsule preparation with auxiliary materials Each capsule contains a Chinese herbal compound capsule containing 6 millimoles of nitric oxide donor.

Embodiment 3

[0039] The embodiment of the present invention provides a nitric oxide donor traditional Chinese medicine compound preparation, which includes active raw materials and auxiliary materials for pills, wherein the active raw materials are composed of the following raw materials in parts by mass: 70 parts of Achyranthes bidentata, 20 parts of Danshen, Taizi 10 parts of ginseng, 5 parts of fried Atractylodes macrocephala, 15 parts of Jiangxiang and 4 parts of leeches.

[0040] This embodiment also provides a preparation method of a nitric oxide donor traditional Chinese medicine compound preparation, which is basically the same as the preparation method provided in Example 1, except that the active dry powder is mixed with auxiliary materials for pills to make each A traditional Chinese medicine compound pill containing 6 mmol of nitric oxide donor.

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Abstract

The invention provides a nitric oxide donor traditional Chinese medicine compound preparation. The preparation comprises active raw materials and pharmaceutical acceptable auxiliary materials, whereinthe active raw materials comprise raw materials in parts by mass as follows: 50-100 parts of a first nitric oxide donor plant, 10-30 parts of a second nitric oxide donor plant, 5-20 parts of radix pseudostellariae, 5-20 parts of roasted rhizoma atractylodis macrocephalae, 5-20 parts of rosewood and 1-10 parts of leeches; and the content of nitric oxide donors in the first nitric oxide donor plantis larger than 1500 mg/kg and smaller than or equal to 3500 mg/kg, and the content of nitric oxide donors in the second nitric oxide donor plant is larger than or equal to 1000 mg/kg and smaller thanor equal to 1500 mg/kg. The nitric oxide donor traditional Chinese medicine compound preparation can be used for preventing or treating cardiovascular and cerebrovascular diseases. The invention provides a preparation method and application of the nitric oxide donor traditional Chinese medicine compound preparation. The preparation method is simple, feasible and easy to implement.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and application. Specifically, the invention relates to a nitric oxide donor traditional Chinese medicine compound preparation and its preparation method and application. Background technique [0002] With the rapid development of China's economy and the improvement of medical services, the life expectancy of Chinese people has increased significantly. The incidence of hypertension increases with age, becoming the disease that most widely affects the health of the middle-aged and elderly population. Hypertension is also one of the main threats of cardiovascular and cerebrovascular diseases. At present, the main treatment for hypertension is to lower blood pressure with drugs, but the antihypertensive drugs have different degrees of toxic and side effects, are expensive, and the blood pressure of most hypertensive populations in my country cannot be controlle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61K36/537A61K36/704A61P9/12A61P9/10A61P1/16A61P11/00A61P1/00A61K35/62
CPCA61K35/62A61K36/185A61K36/21A61K36/23A61K36/28A61K36/284A61K36/36A61K36/424A61K36/48A61K36/537A61K36/704A61P1/00A61P1/16A61P9/10A61P9/12A61P11/00A61K2300/00
Inventor 郭长江胡江平刘宝琴徐学功阎喜英罗红梅罗方王丽萍王宏程新安德鲁高郭予琦郭建成
Owner 郑州恩欧生物科技有限公司
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