Composition for skin repair

A skin repair and composition technology, applied in the field of cosmetics, can solve the problems of raised scars, decreased biological activity, slow folding and modification, etc., and achieve the effect of promoting wound repair, promoting transdermal absorption, and easy degradation and inactivation

Active Publication Date: 2019-12-20
GUANGZHOUJIDABIOLOGICAL TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the skin care products containing collagen used to repair acne marks on the market, the collagen is more or less hydrolyzed, the triple helix structure is loosened (structure change), and becomes 3 free peptide chains, the biological activity is reduced, or even inactivated Can only act as a physical barrier to the skin
On the other hand, the process of skin repair and wound healing involves the synthesis of collagen in the body, but the process of collagen from transcription to translation to folding and modification is relatively slow, and overexpression of collagen may lead to the formation of bulges after skin wound healing. Acute scar

Method used

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  • Composition for skin repair
  • Composition for skin repair
  • Composition for skin repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 4

[0034] Embodiment 4: Preparation of freeze-dried powder for skin restoration.

[0035] About 5% mannitol was added to Comparative Example and Examples 1-3 respectively, and freeze-dried to obtain freeze-dried powder.

Embodiment 5

[0036] Embodiment 5: the preparation of the skin care water that is used for skin restoration.

[0037] Weigh the following components by weight percentage: 1% soluble collagen, 0.5% prolyl hydroxylase, 10% arginine / lysine polypeptide, 3% Korean Pulsatilla (PULSATILLA KOREANA) extract, 3% tooth margin ink FUCUS SERRATUS extract, 5% ZANTHOXYLUM PIPERITUM yeast fermented fruit extract, 3% Centella Asiatica extract, sodium hyaluronate, and water as the balance. Fully mix and homogenize to obtain skin care water.

Embodiment 6

[0038] Embodiment 6: composition repairs skin barrier test

[0039] The effective number of subjects is 100 cases; 18 to 45 years old; Fitzpatrick III or IV skin type; with post-acne pigmentation and other phenomena; the test site has not participated in skin treatment, beauty or other skin tests in the past three months; nearly half a year No chemical peeling or laser treatment was performed, and informed consent was signed.

[0040] Use of the composition: clean the face, and after drying, take 1-2mL of the solution and apply it to the whole face. The comparison group (n=15) was coated with the comparative example, and the experimental group (n=15) was coated with the formula of Examples 1-3. Take it once a day in the morning and evening, and use it continuously for 4 weeks. For the formal test, sit quietly for 30 minutes in a standard room (temperature: 20°C-22°C, humidity: 40%-60%), without drinking water or beverages.

[0041]Use the CK skin tester to detect the averag...

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PUM

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Abstract

The invention discloses a composition for skin repair. The composition is composed of active substances and auxiliary materials. The active substances comprise prolyl hydroxylase and arginine / lysine polypeptide. The active substances also comprise soluble collagen and tripeptide-1 copper. The arginine / lysine polypeptide has the function of promoting transdermal absorption of other active proteins;the polypeptide is used together with the prolyl hydroxylase to promote the prolyl hydroxylase to enter the body through the skin, and cooperates with prolyl hydroxylase in the body to hydroxylate proline on existing procollagen in the body into hydroxyproline, so that the formation of collagen with a triple helix structure is accelerated, wound repair is promoted, and pigmentation is reduced. Meanwhile, due to the existence of the prolyl hydroxylase, a triple helix structure can be well maintained, part of collagen is attached to the surface of the skin to form an isolating membrane protective layer, moisture is preserved and retained, and an internal environment for skin repair is provided.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a composition for skin repair. Background technique [0002] Collagen is a special kind of protein, the most basic molecular structure is procollagen monomer. Procollagen is a fibrous protein composed of three α-peptide chains twisted into a triple helix structure, and its primary structure (Gly-x-y) n The repeat sequence is a necessary condition for the formation of the triple helix structure, where x is often proline, and y is often hydroxyproline or hydroxylysine. The function of a protein depends on its structure, and only collagen with a complete triple-helix stable structure can exert all its functions, so collagen with a triple-helix structure is called active collagen. However, hydroxyproline and hydroxylysine are not encoded in the DNA sequence and cannot be directly translated into (Gly-x-y)n, but are usually encoded by proline residues (Gly-x-x)n or lysine The aci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/65A61K8/66A61K8/73A61K8/9711A61K8/9728A61K8/9789A61Q19/00
CPCA61K8/66A61K8/64A61K8/65A61K8/9789A61K8/9711A61K8/9728A61K8/735A61Q19/00A61K2800/85
Inventor 项琪黄亚东薛来武
Owner GUANGZHOUJIDABIOLOGICAL TECH CO LTD
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