Organ chip

Abstract

The invention discloses an organ chip. The organ chip comprises a No.1 outer-layer chip, a No.1 porous layer is arranged on the outer surface of the lower end of the No.1 outer-layer chip, a middle-layer chip is arranged on the outer surface of the lower end of the No.1 porous layer, and a middle-layer chip is arranged on the outer surface of the lower end of the middle-layer chip. By the aid of the middle-layer chip, the organ chip can simulate tiny structures in human liver organs by a bionic cell culture chamber, a bionic left rear superior border vein, a bionic middle hepatic vein, a bionic left medial lobe vein branch, a bionic left outer lobe vein branch, a bionic caudate lobe vein, a bionic right rear superior border vein, a bionic right hepatic vein, a bionic auxiliary middle hepatic vein, a bionic right anterior lobe vein branch and a bionic right rear upper vein, ensure that cells can better adapt to simulation survival environment, form ultrastructures of liver organs in human bodies and more accurately simulate cell survival environments in human bodies so as to improve medicine detection accuracy and efficiency.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to an organ chip. Background technique [0002] At present, related diseases are mainly studied based on animal models, but it takes a long time, is uncontrollable, cannot be quantified, and cannot perform multi-parameter research. In addition, animal models cannot directly observe the behavior of diseased cells, let alone accurately study the interaction between cells Therefore, it is necessary to develop a novel and effective method to deeply explain the disease mechanism at the cellular level. The organ chip is a microfluidic cell culture device that can simulate the physiological environment at the tissue or organ level. For human disease mechanisms The research has broad application prospects. In the existing technology, the organ chip fails to reconstruct the highly bionic organ ultrastructure and the precise physiological and similar physical and chemical conditions. ...

AI Technical Summary

Problems solved by technology

[0002] At present, related diseases are mainly studied based on animal models, but it takes a long time, is uncontrollable, cannot be quantified, and cannot perform multi-parameter research. In addition, animal models cannot directly observe the behavior of diseased cells, let alone accurately study the interaction between cells Therefore, it is necessary to develop a novel and effective method to deeply explain the disease mechanism at the cellular level. The organ chip is a microfluidic cell culture device that can simulate the physiological environment at the tissue or organ level. For human disease mechanisms The research has broad application prospects. In the existing technology, the organ chip fails to reconstruct the highly bionic organ ultrastructure and the precise physiological and similar physical and chemical conditions.

[0003] CN109868256A discloses a microfluidic chip for co-cultivation of cells. According to the number of simulated organs and cell types, the number of chip layers can be adjusted to achieve the purpose of co-cultivation of different numbers of various types of cells, but it can only achieve the purpose of co-cultivation of cells. Co-culture, there is still a certain difference from the physiological environment and the ultrastructure of the organ cannot be realized

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