Terbinafine hydrochloride spray and preparation method thereof

A technology of terbinafine hydrochloride and spray, which is applied in aerosol delivery, antifungal agents, pharmaceutical formulations, etc. It can solve the problems of difficult preparation into aqueous solution and poor water solubility, etc., and achieve the effect of inhibiting and killing fungi

Inactive Publication Date: 2020-01-03
江苏晨牌邦德药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Terbinafine hydrochloride has poor water solubility and is difficult to prepare into an aqueous solution

Method used

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  • Terbinafine hydrochloride spray and preparation method thereof
  • Terbinafine hydrochloride spray and preparation method thereof
  • Terbinafine hydrochloride spray and preparation method thereof

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0016] Table 1: Example 1 - Component composition of terbinafine hydrochloride spray.

[0017]

[0018] According to the component composition of each embodiment in table 1 respectively, prepare terbinafine hydrochloride spray according to the following method:

[0019] (1) Add terbinafine hydrochloride to ethanol, and mix and stir for 10-15 minutes;

[0020] (2) Add ethylparaben again, and continue mixing and stirring for 10-15 minutes;

[0021] (3) Finally, add purified water, continue mixing and stirring for 10-15 minutes, take an appropriate amount of the obtained sample for testing, and after passing the test, fill it to obtain Terbinafine Hydrochloride Spray.

[0022] Product of the present invention is compared with commercially available terbinafine hydrochloride spray product, and the results are as follows:

[0023] 1. The viscosity of the liquid medicine increases significantly;

[0024] 2. The amount of precipitation is significantly reduced;

[0025] 3. The...

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Abstract

The invention provides terbinafine hydrochloride spray and a preparation method thereof. The terbinafine hydrochloride spray is prepared from the following components: terbinafine hydrochloride, ethylalcohol, ethylparaben and purified water. The preparation method comprises the steps that the terbinafine hydrochloride is added into the ethyl alcohol to be mixed and stirred; the ethylparaben is added for continuous mixing and stirring; and finally, the purified water is added for mixing and stirring, a proper quantity of sample is taken and detected to be qualified, and then filling is conducted to obtain the terbinafine hydrochloride spray. The terbinafine hydrochloride is dissolved in the ethyl alcohol and the purified water, fungus ergot squalene epoxidase can be inhibited in a highly selective mode, ergot squalene epoxidation reaction in the fungus cytomembrane forming process is blocked to disturb early biosynthesis of fungus sterol, and thus the effect of inhibiting and killing the fungus are exerted.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a terbinafine hydrochloride spray and a preparation method thereof. Background technique [0002] Terbinafine hydrochloride can be used to treat trichophyton (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucous, Trichophyton cleavus and Trichophyton violaceum, etc.), Microsporum canis and flocculent Infections of the skin, hair, and nails caused by, for example, epidermophyton. It can also treat various tinea diseases (tinea corporis, jock itch, tinea manus, tinea capitis, etc.) ). [0003] Terbinafine hydrochloride belongs to the allylamine antifungal drug, which mainly exerts strong antibacterial and bactericidal effects by inhibiting squalene cyclooxygenase. It has a wide antibacterial spectrum and strong bactericidal power, and is particularly sensitive to dermatophytes. Clinical application very broad. Common dermatophytes in small animals clinically include ...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K9/12A61K47/10A61K31/137A61P31/10
CPCA61K9/12A61K31/137A61K47/10A61P31/10
Inventor庄永辉
Owner江苏晨牌邦德药业有限公司