Biocompatible aggregation-induced luminogen and application thereof

A biocompatible, luminophore technology, applied in the field of fluorescence detection, can solve problems that have not been reported before

Inactive Publication Date: 2020-01-17
THE HONG KONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, until now, its AIE characteristics have barely been reported

Method used

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  • Biocompatible aggregation-induced luminogen and application thereof
  • Biocompatible aggregation-induced luminogen and application thereof
  • Biocompatible aggregation-induced luminogen and application thereof

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Embodiment Construction

[0024] definition

[0025] The following definitions are provided for purposes of understanding this application and for constructing the appended claims.

[0026] "Aggregation-induced emission" means that fluorescence / phosphorescence is turned on in aggregated form or in the solid state; when molecules are dissolved, the material is non-emitting; however, when intramolecular rotation is restricted, emission is turned on.

[0027] "Emission intensity" refers to the magnitude of fluorescence / phosphorescence measured from a fluorescence spectrometer or a fluorescence microscope.

[0028] "Fluorophore" refers to a molecule that exhibits fluorescence.

[0029] "Emitter" refers to a molecule that exhibits light emission.

[0030] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

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Abstract

The present subject material relates to the discovery of Berberine Chloride as aggregation induced emission (AIE) luminogen and use of this material in staining lipid droplets both in mammalian cellsand in living tissue slices. In particular, the present innovation is associated with proposing a new source to acquire more natural AIEgens with obvious advantages over artificial luminogens.

Description

[0001] related application [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 763,915, filed July 10, 2018, the applicant of which is the inventor of this patent application, and is hereby incorporated by reference in its entirety to Reference. technical field [0003] This application relates to the technical field of fluorescence detection, in particular to a luminescent berberine hydrochloride with aggregation-induced emission (AIE) characteristics, which is used to stain lipid droplets in mammalian cells and biopsy sections, compared to Artificial luminophores, the natural aggregation-induced luminophores have distinct advantages. Background technique [0004] Light is integral to human existence. Driven by curiosity and the key role of light in human life, people have never stopped searching for ideal illuminants and exploring the nature of light. In fact, the study of luminescent materials has not only deepened our understanding...

Claims

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Application Information

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IPC IPC(8): C07D455/03C09K11/06G01N21/64
CPCC07D455/03C09K11/06G01N21/6428C09K2211/1029C09K2211/1088
Inventor 唐本忠顾渊赵征
Owner THE HONG KONG UNIV OF SCI & TECH
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