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Meniscus regeneration substrate

A meniscus and substrate technology, which can be used in tissue regeneration, medical science, knee joint, etc., and can solve the problem of not promoting meniscus regeneration.

Active Publication Date: 2020-01-17
EDUCATIONAL FOUND OF OSAKA MEDICAL & PHARMA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in practice, there is a problem that meniscus regeneration is not promoted as expected even when using existing tissue regeneration substrates.

Method used

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  • Meniscus regeneration substrate
  • Meniscus regeneration substrate
  • Meniscus regeneration substrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] (1) Preparation of non-woven layer

[0067] Polyglycolide with a weight-average molecular weight of 250,000 colored in green is used as a bioabsorbable material, and it is spun, and the cloth made of the obtained thread with an average fiber diameter of 31 denier is processed by a needle punching method. In the method of producing a nonwoven fabric, a nonwoven fabric colored green with an average fiber diameter of about 20 μm and a thickness of about 300 μm was obtained.

[0068] Fourteen of the obtained nonwoven fabrics were stacked, and needle-punched from one surface in this state, thereby compositely integrating them. Next, the combined and integrated laminate was hot-pressed at a temperature of 100°C for 1 minute, and then sewn at a pitch of 5 mm using polyglycolide threads of 400 denier to obtain a nonwoven fabric with a thickness of 3.7 mm. layer.

[0069] When the 50% compressive stress was measured by the method based on JIS-K6767 about the obtained nonwoven ...

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Abstract

The purpose of the present invention is to provide a meniscus regeneration substrate which, when used to fill in defects in a meniscus of a knee joint in therapy to regenerate the meniscus, can promote regeneration of the meniscus. The present invention is a meniscus regeneration substrate which, when used to fill in defects in a meniscus of a knee joint in therapy to regenerate the meniscus, canpromote regeneration of the meniscus, wherein: the meniscus regeneration substrate has a structure obtained by combining and integrating, in the stated order, a sponge layer composed of a bioabsorbable material that breaks down more slowly than polyglycolide, a nonwoven fabric layer composed of polyglycolide, and a sponge layer composed of a bioabsorbable material that breaks down more slowly thanpolyglycolide; the 50% compressive stress of the nonwoven fabric layer is 0.5 MPa or greater; and the nonwoven fabric layer has a thickness of 2 mm or greater.

Description

technical field [0001] The invention relates to a meniscus regeneration base material capable of promoting meniscus regeneration by filling the defective part of the meniscus of the knee joint in the regeneration treatment of the meniscus. Background technique [0002] The meniscus is the cartilage-like tissue that exists inside the knee joint. Below, use figure 1 and 2 Describe the structure of the knee joint. figure 1 is a schematic view of the sagittal plane of the right knee joint, figure 2 is a cross-sectional schematic view of the right knee joint. Such as figure 1 As shown, the knee joint has a meniscus 1 between the femur 4 and the tibia 5, and cartilage 3 is formed on the opposite sides of the femur 4 and the tibia 5, respectively. There is a patella 6 in front of the knee, and an infrapatellar fat pad (IPFP: Infrapatellar Fat Pad) 2 in its lower part. The knee joint is wrapped by the joint capsule 7, and the inside of the joint is filled with the joint flui...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61F2/38A61L27/44A61L27/50A61L27/56A61L27/58
CPCA61F2/38A61L27/18A61L27/44A61L27/50A61L27/56A61L27/58A61L2430/06
Inventor 大槻周平井上多惠瀬崎峻辅
Owner EDUCATIONAL FOUND OF OSAKA MEDICAL & PHARMA UNIV