A kind of anti-poisoning water-soluble peroxide decomposition catalyst and its preparation method and application

A technology of peroxide decomposition and catalyst, applied in the direction of organic compound/hydride/coordination complex catalyst, physical/chemical process catalyst, organic chemical method, etc. Poison inactivation effect

Active Publication Date: 2020-09-08
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, the research on peroxide decomposition catalysts mainly focuses on heterogeneous noble metal catalysts (gold, silver, palladium, osmium, platinum) and metal oxide catalysts (MnO 2 , Fe 2 o 3 , CeO 2 、Gd 2 o 3 etc.), in the research of homogeneous catalysts, mainly including Schiff base (Schiff base), Salen, porphyrin, macrocyclic polyamine, and phthalocyanine (MPc) and other small molecule metal complexes, all Phase catalysts are easily poisoned and inactivated by impurities or other interference factors due to the exposed metal centers, and at the same time, the exposed metal centers are easy to interact with amino acid residues in the organism or form m-O bridge agglomerations, which can easily lead to biological toxicity
In real life, in addition to industrial applications, peroxide decomposition catalysts can also be applied to the field of biomedical drugs, such as the treatment of catalase deficiency as a metal drug, and the removal of hydrogen peroxide used in the manufacture of cheese in the food industry , cleaning solution in contact lenses, cancer cell oxygenizer in cancer treatment, etc., but if these applications are to be satisfied, the corresponding catalyst needs to meet low toxicity or non-toxicity in addition to good catalytic effect. Toxicity, good water solubility, but studies that take into account these characteristics have not been reported

Method used

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  • A kind of anti-poisoning water-soluble peroxide decomposition catalyst and its preparation method and application
  • A kind of anti-poisoning water-soluble peroxide decomposition catalyst and its preparation method and application
  • A kind of anti-poisoning water-soluble peroxide decomposition catalyst and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Synthesis of Mononuclear Iron(Ⅱ) Complex Fe-1

[0043] Pour taurine (500mg, 4mmol), 2,6-diacetylpyridine (326mg, 2mmol), potassium hydroxide (224mg, 4mmol) and methanol (100mL) into a 250mL round bottom flask in turn, and heat to 85°C Reflux for 12 hours. After cooling to room temperature, a milky white solid was obtained by filtration. Denoted as ligand L1; the ligand L1 obtained above was dispersed in (50 ml) methanol solution, and 10 ml of ferrous perchlorate hexahydrate (256 mg, 1 mmol) in methanol solution was slowly added thereto. After stirring for a few minutes, the temperature was raised to 85°C for 2h. Cool to room temperature, filter, concentrate the filtrate to 10 mL by rotary evaporation under reduced pressure, seal it and put it in a refrigerator at -16°C, take it out after standing for 2 hours, and a large number of dark purple microcrystals are precipitated. Denoted as complex Fe-1, its single crystal structure, magnetic properties, electrochemical pr...

Embodiment 2

[0045] Embodiment 2: the synthesis of mononuclear iron (II) complex Fe-2

[0046] Pour beta-alanine (356mg, 4mmol), 2,6-diacetylpyridine (326mg, 2mmol), potassium hydroxide (224mg, 4mmol) and methanol (100mL) into a 250mL round bottom flask in turn, and heat to Reflux reaction at 85°C for 12 hours, the solution gradually changed from colorless to orange yellow. After cooling to room temperature, the solvent was removed by rotary evaporation under reduced pressure, and the product was washed 3 times with cold methanol to obtain a yellow solid. Denoted as ligand L2; ligand L2 was dissolved in (50ml) methanol solution, and 10ml of ferrous perchlorate hexahydrate (256mg, 1mol) in methanol solution was slowly added thereto. After stirring for a few minutes, the temperature was raised to 85°C for 2h. Cool to room temperature, filter, concentrate the filtrate to 10 mL by rotary evaporation under reduced pressure, seal it and put it in a refrigerator at -16°C, and take it out after ...

Embodiment 3

[0048] Embodiment 3: the synthesis of mononuclear iron (II) complex Fe-3

[0049] Pour 4-aminobenzenesulfonic acid (692mg, 4mmol), 2,6-diacetylpyridine (326mg, 2mmol), potassium hydroxide (224mg, 4mmol) and methanol (100mL) into a 250mL round bottom flask in turn, and heat to Reflux at 85°C for 12 hours. After cooling to room temperature, a milky white solid was obtained by filtration. Denoted as ligand L3; the ligand L3 obtained above was dispersed in (50 ml) methanol solution, and 10 ml of ferrous perchlorate hexahydrate (256 mg, 1 mol) in methanol solution was slowly added thereto. After stirring for a few minutes, the temperature was raised to 85°C for 2h. Cool to room temperature, filter, concentrate the filtrate to 10 mL by rotary evaporation under reduced pressure, seal it and put it in a refrigerator at -16°C, take it out after standing for 2 hours, and a large number of dark purple microcrystals are precipitated. Recorded as complex Fe-3.

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Abstract

The invention belongs to the technical field of application of functional coordination compounds and in particular relates to a poisoning-resistant water-soluble peroxide decomposition catalyst as well as preparation and application thereof. In the water-soluble peroxide decomposition catalyst, a metal center is protected by a ligand in a catalysis process and does not directly react with a substrate and other impurities, so that the possibility of deactivation caused by poisoning is avoided; polar groups such as a sulfonic group, a carboxylic group and hydroxyl on the outer layer of a designed electronic sponge type catalysis center can endow a corresponding coordination compound with very good water solubility, and also can participate in an elementary reaction in which the polar groupsare transferred along with protons and electrons; when the electronic sponge type catalysis center reacts with the substrate, the electrons can be transferred through an outer-layer electron transferring mechanism by using electronic properties of delocalization so as to realize the aim of oxidation reduction; and an experiment proves that this coordination compound has a very good catalytic capability on peroxide decomposition, and is expected to become one type of catalyst or metal drug practical in the field of biochemical drugs.

Description

technical field [0001] The invention belongs to the technical field of application of functional complexes, and specifically relates to the preparation of water-soluble metal complex catalysts by tridentate Non-innocent ligands with redox activity and its preparation method and application. Background technique [0002] Catalase (CAT) can catalyze H 2 o 2 Decomposed into non-toxic water and oxygen, its unique high-efficiency catalytic performance is of great significance to disease treatment, anti-aging, health care and beauty, food industry, textile printing and dyeing, paper industry and other aspects. However, natural enzymes have the characteristics of large molecular weight, poor cell permeability, easy inactivation, difficult extraction, and high cost. Therefore, it is particularly important to synthesize catalysts with natural antioxidant enzyme functions. [0003] In the current design of peroxide decomposition catalysts, many are designed based on the active cente...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J31/22C07D213/76A61P29/00
CPCA61P29/00B01J31/1815B01J2531/0244B01J2531/26B01J2531/72B01J2531/821B01J2531/842B01J2531/845C07B2200/13C07D213/76
Inventor 刘高峰
Owner SUN YAT SEN UNIV
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