Synthesis method of trifluralin

Abstract

The invention discloses a synthesis method of trifluralin. The method uses 4-chloro-3,5-dinitrotrifluorotoluene and di-n-propylamine as raw materials, a base as an acid binding agent, and vitamin C asan auxiliary agent, and the target compound is prepared under heating. The advantages of the method are as follows: (1) the used raw materials and auxiliary materials are wide in source, and convenient in preparation; (2) the catalytic effect is good, a raw material conversion rate is high, and the product selectivity is good; and (3) the content of N-nitroso-di-n-propylamine in the product is low, the post-treatment is simple and convenient, the method is a new preparation process of trifluralin, and the large-scale industrial development is facilitated.

Description

[0001] a technical field

[0002] The invention relates to a synthesis method of trifluralin, belonging to the technical field of chemical material preparation. This method is suitable for preparing the target by heating reaction under normal pressure with 4-chloro-3,5-dinitrobenzotrifluorotoluene and di-n-propylamine as raw materials, alkali as acid-binding agent, vitamin C as auxiliary agent, and water as reaction medium. In the case of compounds.

[0003] Two background technology

[0004] Fluoraline (2,6-dinitro-N, N-dipropyl-4-(trifluoromethyl)aniline) Chinese alias: 2,6-dinitro-N, N-dipropyl-4-trifluoromethylaniline, It is orange-yellow crystal, with a melting point of 48.5°C-49°C (original drug 43°C-47.5°C), a boiling point of 139°C-140°C, and a density of 1.36g / cm3 (22°C). Solubility in water at 25°C: 0.184g / L at pH5, 0.221g / L at pH=7, 0.189g / L at pH9; in acetone, chloroform, acetonitrile, toluene, ethyl acetate at 25°C The solubilities are all greater than 1 000g / L,...

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