Purpose of kukoline or salt thereof to preparation of medicines for reducing blood uric acid level and preventing and treating uric acid type nephropathy

Abstract

The invention relates to a purpose of kukoline or salt thereof to preparation of medicines for reducing blood uric acid level and preventing and treating uric acid type nephropathy, and belongs to thefield of pharmaceuticals. On one hand, the invention provides the purpose of the kukoline or salt thereof to preparation of medicines or health-care products for reducing blood uric acid level, and on the other hand, the invention also provides the purpose of the kukoline or the salt thereof to preparation of medicines for preventing and / or treating uric acid type nephropathy. Animal experiment proves that the kukoline can substantially reduce the blood uric acid level, and besides, can increase the renal tubule expansion and gangrene degree and the renal fibrosis degree of mice suffering from hyperuricaemia. The application of the kukoline or the salt thereof can provide a new medication selection for clinical treatment of the hyperuricaemia and high hyperuricemic nephropathy caused by the hyperuricaemia.

Description

technical field [0001] The invention relates to the use of sinomenine or a salt thereof in the preparation of medicines for reducing blood uric acid level and preventing and treating uric acid nephropathy, which belongs to the field of medicine. Background technique [0002] Hyperuricemia refers to a normal purine diet, and the fasting serum uric acid level is measured twice on different days ≥ 416 μmol / L (7 mg / dl) for men and ≥ 357 μmol / L (6 mg / dl) for women. In recent years, many studies at home and abroad have confirmed that hyperuricemia is closely related to the occurrence and development of gout, cardiovascular disease, metabolic syndrome, hypertension and kidney disease. Hyperuricemia is an important reason for the increased prevalence of Chronic Kidney Disease (CKD) and is an independent risk factor for the progression of CKD. Studies have shown that lowering blood uric acid levels can slow the progression of kidney disease. The treatment of hyperuricemia nephropat...

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Problems solved by technology

[0006] However, there have been no related reports that sinomenine has the effect of lowering uric acid and preventing and treating uric acid nephropathy.

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