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Self-actuating articles

A technology of products and supporting materials, applied in the field of self-actuating products, which can solve the problems of increased volume and unstable active pharmaceutical ingredients

Active Publication Date: 2020-03-17
MASSACHUSETTS INST OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these liquid formulations can cause the active pharmaceutical ingredient (API) to become unstable and thus may require refrigeration and / or significantly increase the bulk of the dose due to the required dilution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0315] Example 1 - Self-righting article

[0316] A self-righting article consisting of a specific shape and / or density profile (optionally with a capacity to be encapsulated in a standard "000", "00" size capsule, or possibly smaller or larger capsules) is provided. For example, the distribution of density and / or shape can be such that:

[0317] 1. The design has only one stable point and one unstable point so that it always self-rightes to a single configuration and orientation;

[0318] 2. The article is designed to have a relatively short settling time from each possible orientation to its stable configuration;

[0319] 3. The design minimizes the destabilizing effects of forces in the GI tract (eg, fluid flow and muscle contraction); and / or

[0320] 4. The design allows articles of various shapes and weights to be loaded into the system through hollow slots created in specific locations on the article.

[0321] In some cases, the article shape is derived from a smooth ...

Embodiment 2

[0326] A solid shape generated by rotating a smooth curve defined around the y-axis (example: Figure 7 ). The shape is composed of a biocompatible polymer (example: PCL, PLA, PEG) in all areas with positive y-values ​​and a biocompatible ceramic (example: hydroxyapatite) in all areas with negative y-values Or metal (example: stainless steel, Field metal). The ratio of the densities of the two materials should be 6:1 to 16:1. Artifacts can be scaled to any length, but Figure 7 The dots in describe the Figure 8 ) such as the object in capsule No. 000.

[0327] The shape has been tested for its righting ability against ellipsoids and spheres of the same volume and similar dimensions. The articles were tested under a high speed camera at 1000 FPS in several different liquids including water, oil and gastric juice, and on different surfaces including plastic and porcine stomach tissue. result( Figures 9 to 12 ) shows that the article has a faster righting time overall, a...

Embodiment 3

[0332] An object having a shape similar to that described in Example 2, but with holes, inlets and slits built into the article. Such holes and slits can be used to allow fluids to enter the system or can be used to store articles within the system ( Figure 19 ). These slits can also be used to hollow out the article to keep the density ratio at a reasonable value achievable with the available materials. For example, by hollowing out the top section of an article, a higher density material can be used to fill the remaining top area; allowing higher density material because the only constraints on the article are shape and center of mass. When making holes, the product should try to maintain axis symmetry, or as close to axis symmetry as possible.

[0333] Such examples of these holes and slits include but are not limited to the following:

[0334] 1. A cylinder with a radius smaller than the radius of the article centered on the y-axis.

[0335] 2. A conical section cente...

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Abstract

Self-actuating articles including, for example, self-actuating needles and / or self- actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and / or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics). Those of ordinary skill in the art would understand that the term spring is not intended to be limited to coil springs, but generally encompass any reversibly compressive material and / or component which, after releasing an applied compressive force on the material / component, the material / component substantially returns to an uncompressed length of the material / component (e.g., the within 95% of the length of the material / component prior to compression).

Description

[0001] related application [0002] This application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Application Serial No. 62 / 507,647, filed May 17, 2017, entitled "SELF-RIGHTING ARTICLES," filed May 17, 2017 U.S. Provisional Application Serial No. 62 / 507,653, titled "SELF-ACTUATING ARTICLES," filed on 17 May 2017, and U.S. Provisional Application Serial No. 62 / 507,665, titled "COMPONENTS WITH HIGH API LOADING," filed May 17, 2017, Each of which is incorporated herein by reference in its entirety. technical field [0003] The present invention generally relates to self-actuating articles including, for example, self-actuating needles. Background technique [0004] The GI tract presents incredible opportunities for diagnosing and treating patients. The past decade has seen a significant increase in the development of smart dosing systems and articles that can achieve this goal. One of the most significant challenges in maximizing delivery and interaction with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/32A61M5/20
CPCA61M31/00A61M37/0015A61M37/00A61K9/4808A61J3/07A61K9/0002A61K9/0065A61K9/0021A61K9/4866A61M2037/0007A61M5/20A61M5/2033A61M5/286A61M5/3129A61M5/3287A61M5/329A61M5/3295A61M5/281A61M31/002A61K9/0092A61B10/0233A61B10/04A61M2037/0053A61B5/14503A61N1/36007A61M2210/106A61M2205/0238A61M5/14276A61M2205/21A61M2005/14284A61M2005/1585A61K38/28A61M5/158A61M2210/1053A61N1/0509A61N1/325A61M2037/0023A61K9/0012A61B10/02A61B2010/0208A61B5/14539A61M5/3015A61M37/0069A61M2005/1581A61B10/06A61M5/1454
Inventor 卡洛·乔瓦尼·特拉韦尔索亚历克斯·G·阿布拉姆松埃斯特尔·卡法雷尔萨尔瓦多尼克拉斯·罗克西德康民秀泰勒·本泽尔罗伯特·S·兰格
Owner MASSACHUSETTS INST OF TECH
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