Method for improving low ovarian response in patients with polycystic ovary syndrome by transvaginal small follicle puncture

A technology of polycystic ovary and puncture, applied in obstetrics and gynecology equipment, etc.

Inactive Publication Date: 2020-03-27
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] However, there is no report about a method of improving ovarian hyporesponse in pa...

Method used

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  • Method for improving low ovarian response in patients with polycystic ovary syndrome by transvaginal small follicle puncture
  • Method for improving low ovarian response in patients with polycystic ovary syndrome by transvaginal small follicle puncture

Examples

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Embodiment 1

[0042] Please refer to the attached figure 1 , attached figure 2 , with figure 1 It is a flow chart of a method for improving ovarian hyporesponse in patients with polycystic ovary by transvaginal small follicle puncture in this embodiment. figure 2 It is a plan view of a method for improving ovarian hyporesponse in patients with polycystic ovary by transvaginal small follicle puncture in this embodiment.

[0043] The method for improving ovarian hyporesponse in patients with polycystic ovaries by transvaginal small follicle puncture includes case inclusion 1, measurement index 2, and standard operating procedures 3;

[0044]The case inclusion 1 includes inclusion criteria 11 and exclusion criteria 12; the measurement indicators 2 include main research indicators 21, follicular fluid analysis time 22, secondary research indicators 23, serum and follicular fluid analysis time 24, and safety indicators 25 ;

[0045] The standard operating procedure 3 includes a clinical ov...

Embodiment 2

[0047] Please refer to the attached figure 1 , attached figure 2 , with figure 1 It is a flow chart of a method for improving ovarian hyporesponse in patients with polycystic ovary by transvaginal small follicle puncture in this embodiment. figure 2 It is a plan view of a method for improving ovarian hyporesponse in patients with polycystic ovary by transvaginal small follicle puncture in this embodiment.

[0048] Inclusion and Exclusion Criteria

[0049] 1) Inclusion criteria included: patients diagnosed with PCOS according to the Rotterdam criteria: (i) oligomenorrhoea or amenorrhea (cycle >35 days), (ii) androgen excess (defined as Ferriman-Gallwey score ≥8, testosterone > 2.5 nmol / l, and / or androstenedione >9.0 nmol / l), (iii) polycystic ovarian morphology (≥12 follicles [2-9mm] in at least 1 ovary). Divide these patients into 3 groups according to the response of the ovaries during ovulation induction: 1) low responders (2 weeks of continuous gonadotropin stimulation...

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Abstract

The invention relates to a method for improving low ovarian response in patients with polycystic ovary syndrome by transvaginal small follicle puncture. The method comprises case inclusion, measurement indicators, and standard operating procedures; The case inclusion comprises inclusion criteria and exclusion criteria; The measurement indicators comprise main research indicators, follicular fluidanalysis time, secondary research indicators, serum and follicular fluid analysis time, and safety indicators; The standard operating procedures comprises a clinical ovulation promotion protocol and aTVOD method. The advantages of the method of the invention are as follows: the method of COS for improving the low ovarian response in patients with PCOS can be performed on the day after the IVF ovulation promotion cycle immediately, and the effect of COS for improving the low ovarian response in patients with PCOS on the day after the IVF treatment cycle can be evaluated, and the underlying mechanisms can be studied.

Description

technical field [0001] The invention relates to the technical field of improving ovarian hyporesponse by small follicle puncture, in particular to a method for improving ovarian hyporesponse in patients with polycystic ovary by transvaginal small follicle puncture. Background technique [0002] Polycystic ovary syndrome (PCOS) is a syndrome of endocrine disorders characterized by rare ovulation or anovulation, hyperandrogen or insulin resistance, and polycystic ovaries. PCOS is the most common endocrine disease among women of childbearing age, with an incidence of 5-18%. Women with PCOS need special attention during ovulation induction during IVF-ET treatment cycles. According to the ovarian response during controlled ovulation stimulation (COS) in IVF cycles, women with PCOS can be divided into 3 subgroups: high response group, normal response group and low response group. For patients in the high response group, the dosage of gonadotropins should be controlled to prevent...

Claims

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Application Information

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IPC IPC(8): A61B17/435
CPCA61B17/435
Inventor 徐步芳张爱军周文洁张丹程美玉司晨晨
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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