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Phenylpropanoid compound and preparation method and application thereof

A kind of technology of phenylpropanoid and compound, which is applied in the field of phenylpropanoid compound and preparation thereof in the seed husk of Aleurites fordii, and can solve the problems of unreported anti-neuroinflammatory activity and the like

Active Publication Date: 2020-04-07
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the anti-neuroinflammatory activity of phenylpropanoids in tung tree

Method used

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  • Phenylpropanoid compound and preparation method and application thereof
  • Phenylpropanoid compound and preparation method and application thereof
  • Phenylpropanoid compound and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) 1 kg of tung tree seed shells were extracted 3 times with 75% ethanol, each time for 2 hours (each dosage: 12 L), and the extract was recovered under reduced pressure to obtain a crude extract;

[0029] (2) The ethanol extract obtained in step (1) is dissolved in water, and then extracted with sherwood oil, ethyl acetate, and n-butanol. The volume ratio of the extract and the extraction solvent is 1:1, and each solvent is extracted 5 times to obtain Extracts of different polar parts;

[0030] (3) The ethyl acetate extract obtained in step (2) was separated by silica gel column chromatography, and eluted successively with petroleum ether: ethyl acetate 10:1, 10:2, 10:3, 10:4;

[0031] (4) Petroleum ether obtained in the above step (3): Ethyl acetate 100:1~100:4 fraction is separated by ODS chromatography, and methanol / water 10:90, 20:80, 40:60, 60:40 For mobile phase gradient elution;

[0032] (5) The methanol / water 10:90~20:80 fraction obtained in the above step (...

Embodiment 2

[0044](1) 1 kg of tung tree seed shell was extracted 3 times with 85% ethanol, each time for 2 hours (each dosage: 14 L), and the extract was recovered under reduced pressure to obtain a crude extract;

[0045] (2) The ethanol extract obtained in step (1) is dissolved in water, and then extracted with sherwood oil, ethyl acetate, and n-butanol. The volume ratio of the extract to the extraction solvent is 1:1, and each solvent is extracted 4 times to obtain Extracts of different polar parts;

[0046] (3) The ethyl acetate extract obtained in step (2) was separated by silica gel column chromatography, and eluted successively with petroleum ether: acetone 10:1, 10:2, 10:3, and 10:4;

[0047] (4) The fraction of petroleum ether obtained in the above step (3): acetone 100:2~100:4 is separated by ODS chromatography, and gradient elution is carried out with methanol / water 10:90, 20:80, 40:60 as the mobile phase ;

[0048] (5) The methanol / water 10:90~20:80 fraction obtained in the ...

Embodiment 3

[0052] (1) 2 kg of tung tree seed shells were extracted 3 times with 75% ethanol, each time for 2 hours (each dosage: 25 L), and the extract was recovered under reduced pressure to obtain a crude extract;

[0053] (2) The ethanol extract obtained in step (1) is dissolved in water, and extracted with sherwood oil, ethyl acetate, and n-butanol successively, and the volume ratio of the extract and the extraction solvent is 1: 1, and each solvent is extracted 3 times to obtain Extracts of different polar parts;

[0054] (3) The ethyl acetate extract obtained in step (2) was separated by silica gel column chromatography, and eluted successively with dichloromethane:methanol 100:2, 100:4, 100:6, 100:8;

[0055] (4) Dichloromethane obtained in the above step (3): Methanol 100: 2~100: 4 fractions are separated by ODS chromatography, with methanol / water 10:90, 20:80, 40:60, 60:40 as Mobile phase gradient elution;

[0056] (5) The methanol / water 10:90~20:80 fraction obtained in the ab...

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Abstract

The invention belongs to the technical field of medicine, and relates to phenylpropanoid and a preparation method and application thereof, in particular to three new pieces of phenylpropanoid and a preparation method thereof and application in preparation of medicine for preventing or treating neurodegenerative diseases. The structure of the compound is as described in the specifications.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to phenylpropanoid compounds in tung tree seed shells, a preparation method and application thereof. Background technique [0002] Tung tree (Vernicia fordii), also known as three-year tung tree, tung tree, tung oil tree, tung tree, and light tung tree, is a plant of the genus Tung tree in Euphorbiaceae. Tung Tung is cold in nature, sweet in taste, slightly pungent, and poisonous. Its roots, leaves and seeds can be used as medicine. There are 3 species in the world, distributed in eastern Asia, and 2 species in my country, mainly produced in Hunan, Sichuan, Guizhou and other provinces. [0003] Tung tung was first recorded in the Dictionary of Traditional Chinese Medicine published by Shanghai Science and Technology Press in 1986. Its leaves, roots and seeds all have anti-inflammatory effects. In 1990, the literature reports "Fujian Folk Herbal Medicine" and "Caomu R...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C43/178C07C41/34C07C41/36C07C41/38A61K31/075A61P25/00A61P25/28
CPCC07C43/1783C07C41/34C07C41/36C07C41/38A61K31/075A61P25/00A61P25/28C07B2200/07Y02A50/30
Inventor 李宁陈刚周地
Owner SHENYANG PHARMA UNIVERSITY
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