Liver tumor angiogenesis quantitative analysis method based on dynamic ultrasound contrast

A technology of contrast-enhanced ultrasound and angiogenesis, applied in image analysis, image data processing, instruments, etc., can solve the problems of respiratory movement interference, loss of regional perfusion information, and poor repeatability of inspection, and achieve the effect of eliminating interference

Active Publication Date: 2020-04-07
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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Problems solved by technology

However, there are still many problems to be solved in the evaluation of tumor blood perfusion by contrast-enhanced ultrasound, including poor reproducibility of examination, interference of respiratory movement, loss of regional perfusion information, uniformity of tumor angiogenesis, and strong subjectivity of infiltration assessment, etc.

Method used

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  • Liver tumor angiogenesis quantitative analysis method based on dynamic ultrasound contrast
  • Liver tumor angiogenesis quantitative analysis method based on dynamic ultrasound contrast
  • Liver tumor angiogenesis quantitative analysis method based on dynamic ultrasound contrast

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Embodiment 1

[0033] A method for quantitative analysis of liver tumor angiogenesis based on dynamic contrast-enhanced ultrasound, comprising the following steps:

[0034] (1) Track the lesion area through the twin convolutional network based on spatial feature recalibration, thereby eliminating the interference caused by respiratory movement on the quantitative analysis of contrast-enhanced ultrasound;

[0035] (2) Using the ultrasound-enhanced sub-sequence obtained in step (1) without respiratory interference, the local perfusion pattern is extracted through a stable component analysis algorithm;

[0036] (3) Quantify the difference in local perfusion patterns in the tumor interior and surrounding normal tissues through a similarity measure based on perfusion phase constraint matching;

[0037] (4) Taking the local tissue as the network node, and based on the perfusion similarity calculated in step (3) as the edge, a network graph representing the difference of angiogenesis in the tumor i...

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Abstract

The invention discloses a liver tumor angiogenesis quantitative analysis method based on dynamic ultrasound contrast. Through local perfusion mode difference quantification, the liver tumor angiogenesis quantitative analysis method constructs a network graph reflecting blood vessel distribution structures of normal tissues in and around a tumor, so that spatial heterogeneity of functions and formsof a tumor region is represented, and a new tumor angiogenesis quantitative evaluation method is provided for clinical imaging doctors. According to the liver tumor angiogenesis quantitative analysismethod, the local perfusion mode is extracted on the basis of inhibiting motion interference, and the local perfusion mode difference is quantified on the basis of perfusion phase constraint, and then the tumor local angiogenesis difference is represented through a complex network, so that heterogeneity characteristics associated with clinical tumor diagnosis and prognosis evaluation are mined.

Description

technical field [0001] The invention relates to the technical field of contrast-enhanced ultrasound analysis, in particular to a quantitative analysis method for hepatic tumor angiogenesis based on dynamic contrast-enhanced ultrasound. Background technique [0002] Contrast-enhanced Ultrasound (CEUS), as a molecular imaging technology, can accurately display the micro arteries and veins and blood perfusion in tissues. Compared with traditional grayscale ultrasound and color Doppler ultrasound imaging techniques, CEUS can effectively improve the sensitivity and specificity of diagnosis. At the same time, CEUS has the characteristics of safety, cheapness, and non-invasiveness. It has made great progress in clinical tumor diagnosis in my country in the past 10 years. Tumor angiogenesis is the basis of tumor growth and invasion. Therefore, quantitative analysis of angiogenesis in and around tumors is an important direction for evaluating tumor malignancy, metastasis and recurre...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/00G06T7/246
CPCG06T7/0012G06T7/248G06T2207/10132G06T2207/20081G06T2207/20084G06T2207/30056G06T2207/30096G06T2207/30101
Inventor 张道强万鹏陈芳
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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