Early diagnosis reagent for of kawasaki disease and application thereof

A technology for early diagnosis and Kawasaki disease, applied in the medical field, can solve problems such as non-specific diagnosis, and achieve the effect of low cost and easy operation

Pending Publication Date: 2020-04-14
AFFILIATED CHILDRENS HOSPITAL OF CAPITAL INST OF PEDIATRICS
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, KD is mainly diagnosed based on clinical manifestations without specific diagnosis

Method used

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  • Early diagnosis reagent for of kawasaki disease and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Detection of TSP-1 and / or TSP-2 in Kawasaki disease plasma

[0031] 1. Materials and methods

[0032] 1. General information:

[0033] The study was divided into Kawasaki disease group and control group. The Kawasaki disease group consisted of 51 children who were hospitalized in the Children's Hospital Affiliated to the Capital Institute of Pediatrics from June 2009 to March 2012 and were diagnosed with Kawasaki disease for the first time according to the diagnostic criteria, including 33 males and 18 females, with a male to female ratio of 1.8 : 1, aged 0.25 to 8.9 years old, with an average of 2.2 years old. The group was divided into two subgroups according to the heart involvement. The heart involvement group refers to those who were abnormal in one of the echocardiography, electrocardiogram, and myocardial enzymes tests; those without abnormalities in all items were the non-cardiac involvement group. There were 21 cases in the control group, includin...

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PUM

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Abstract

The invention provides an early diagnosis reagent for the children Kawasaki disease and application thereof. The reagent is a thrombospondin detection reagent and can be used for early diagnosis of Kawasaki disease. The invention also provides application of the reagent in preparation of a kit for early diagnosis of Kawasaki disease. The kawasaki disease is diagnosed in an assisted mode by detecting the content of thrombospondin in blood plasma of a suspected child patient and thus the suspected child patient can be diagnosed and treated in the early stage, so that cardiovascular diseases andother pathological changes are prevented.

Description

[0001] field of invention [0002] The invention belongs to the field of medicine, and in particular relates to a reagent for early diagnosis of Kawasaki disease and its application, especially a reagent for detecting thrombospondin in blood plasma, and the reagent used in the preparation of a kit for early diagnosis of Kawasaki disease the use of. [0003] technical background [0004] Kawasaki disease (KD) tends to occur in children under 5 years old. Although the etiology is not yet clear, it is generally believed that the occurrence of the disease is related to abnormal immune response. The pathological change is systemic vasculitis, which can involve arteries, veins, and capillaries, especially coronary artery damage, which can lead to coronary aneurysm, myocardial infarction, and sudden cardiac death in severe cases. At present, with the improvement of the efficacy and prognosis of infectious diseases, Kawasaki disease has replaced rheumatic fever as the most common caus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/32
Inventor 李晓惠姜茜孟莉姚玮杨帅张明明林瑶刘杨李爱杰石琳
Owner AFFILIATED CHILDRENS HOSPITAL OF CAPITAL INST OF PEDIATRICS
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