Early diagnosis reagent for of kawasaki disease and application thereof

Abstract

The invention provides an early diagnosis reagent for the children Kawasaki disease and application thereof. The reagent is a thrombospondin detection reagent and can be used for early diagnosis of Kawasaki disease. The invention also provides application of the reagent in preparation of a kit for early diagnosis of Kawasaki disease. The kawasaki disease is diagnosed in an assisted mode by detecting the content of thrombospondin in blood plasma of a suspected child patient and thus the suspected child patient can be diagnosed and treated in the early stage, so that cardiovascular diseases andother pathological changes are prevented.

Description

[0001] field of invention [0002] The invention belongs to the field of medicine, and in particular relates to a reagent for early diagnosis of Kawasaki disease and its application, especially a reagent for detecting thrombospondin in blood plasma, and the reagent used in the preparation of a kit for early diagnosis of Kawasaki disease the use of. [0003] technical background [0004] Kawasaki disease (KD) tends to occur in children under 5 years old. Although the etiology is not yet clear, it is generally believed that the occurrence of the disease is related to abnormal immune response. The pathological change is systemic vasculitis, which can involve arteries, veins, and capillaries, especially coronary artery damage, which can lead to coronary aneurysm, myocardial infarction, and sudden cardiac death in severe cases. At present, with the improvement of the efficacy and prognosis of infectious diseases, Kawasaki disease has replaced rheumatic fever as the most common caus...

AI Technical Summary

Problems solved by technology

[0006] At present, KD is mainly diagnosed based on clinical manifestations without specific diagnosis

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