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Reduced dimensionality structured illumination microscopy with patterned arrays of nanowells

A patterning and patterning technology, applied in nanotechnology, nanotechnology, nanotechnology for sensing, etc.

Pending Publication Date: 2020-04-21
ILLUMINA INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Overlaying the sample 100 with an optical diffraction grating pattern 102 having a known lower spatial frequency results in moiré fringes, although the sample 100 may include higher spatial frequencies that are not resolved

Method used

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  • Reduced dimensionality structured illumination microscopy with patterned arrays of nanowells
  • Reduced dimensionality structured illumination microscopy with patterned arrays of nanowells
  • Reduced dimensionality structured illumination microscopy with patterned arrays of nanowells

Examples

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Embodiment Construction

[0041] As used herein, with respect to diffracted light emitted by a diffraction grating, the term "order" or "order" is intended to mean the number of integer wavelengths representing the number of wavelengths from adjacent slits of the diffraction grating for constructive interference. The path length of light is poor. The term "zeroth order" or "zeroth order maximum" is intended to refer to the central bright fringe emitted by the diffraction grating where there is no diffraction. The term "first order" is intended to refer to the two bright fringes emitted on either side of the zero order fringe, where the path length difference is ±1 wavelength.

[0042] As used herein, with respect to a sample, the term "spot" or "feature" is intended to mean a point or region in a pattern that can be distinguished from other points or regions by relative position. Individual spots may include one or more molecules of a particular type. For example, a spot may comprise a single target ...

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Abstract

Techniques are described for reducing the number of angles needed in structured illumination imaging of biological samples through the use of patterned flowcells, where nanowells of the patterned flowcells are arranged in, e.g., a square array, or an asymmetrical array. Accordingly, the number of images needed to resolve details of the biological samples is reduced. Techniques are also described for combining structured illumination imaging with line scanning using the patterned flowcells.

Description

[0001] Cross References to Related Applications [0002] This application claims U.S. Provisional Patent Application No. 62 / 621,564, filed January 24, 2018, and titled "Reduced Dimensionality Structured Illumination Microscopy With Patterned Arrays Of Nanowells," and filed March 20, 2018, and titled " Priority of Dutch patent application number N2020622 for "Reduced Dimensionality Structured Illumination Microscopy With Patterned Arrays Of Nanowells". The entire contents of each of the foregoing applications are incorporated herein by reference. Background technique [0003] Many recent developments in biological research have benefited from improved methods for analyzing and sequencing nucleic acids. For example, the Human Genome Project has determined the entire sequence of the human genome, which it is hoped will lead to further discoveries in areas ranging from disease management to basic science development. Recently, a number of new DNA sequencing techniques have been...

Claims

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Application Information

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IPC IPC(8): G06K9/78G01N1/28B82Y15/00G06V10/10
CPCB01L3/502B01L3/50851B01L3/50853G01N21/05G01N21/6408G01N21/6452G01N21/6458G01N2021/6419G01N2021/6421G01N2021/6482G02B21/06G02B27/58G06V10/10B82Y15/00B01L2300/0663B01L3/5085G02B21/16B01L2300/0654B01L2300/0896G02B21/00G02B27/425B01L2300/0893G02B21/365
Inventor G·M·斯金纳G·W·埃文斯S·S·洪
Owner ILLUMINA INC
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