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Composition for resisting propionibacterium acnes and regulating skin micro-ecology and application thereof

A technology of Propionibacterium acnes and its composition, which is applied in the field of medicine and biology, can solve the problems of lack of drugs that can effectively regulate skin microecology, and achieve the effects of weakening skin invasiveness, preventing and treating acne, and weakening film-forming growth

Pending Publication Date: 2020-04-24
湖州中科金羿医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is also a lack of drugs that effectively regulate the skin microecology in the prior art

Method used

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  • Composition for resisting propionibacterium acnes and regulating skin micro-ecology and application thereof
  • Composition for resisting propionibacterium acnes and regulating skin micro-ecology and application thereof
  • Composition for resisting propionibacterium acnes and regulating skin micro-ecology and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A composition for resisting Propionibacterium acnes and regulating skin microecology, comprising the following components in parts by weight:

[0034]

[0035] The molecular weight of the polylysine is 3900-4000.

[0036] The cordycepin is derived from the extract of Cordyceps sinensis.

[0037] The pH regulator is citric acid.

[0038] A preparation method of a composition for resisting Propionibacterium acnes and regulating skin microecology, comprising the following steps:

[0039] (1) Weigh each component according to the formula amount, add the pH regulator into water, adjust the pH to 5.2, and prepare the mixture for subsequent use;

[0040] (2) Add nisin, polylysine, cordycepin, and lysozyme to the mixture prepared in step (1), stir and dissolve until the prepared mixture is transparent, and a kind of anti-propionibacterium acnes and regulating The composition of the skin microecology.

Embodiment 2

[0042] A composition for resisting Propionibacterium acnes and regulating skin microecology, comprising the following components in parts by weight:

[0043]

[0044] The molecular weight of the polylysine is 4000-4100.

[0045] The water is sterilized deionized water.

[0046] The cordycepin is derived from the extract of Cordyceps sinensis.

[0047] The pH regulator is citric acid.

[0048] A preparation method of a composition for resisting Propionibacterium acnes and regulating skin microecology, comprising the following steps:

[0049] (1) Weigh each component according to the formula amount, add the pH regulator into water, adjust the pH to 5.8, and prepare the mixture for subsequent use;

[0050] (2) Add nisin, polylysine, cordycepin, and lysozyme to the mixture prepared in step (1), stir and dissolve until the prepared mixture is transparent, and then the anti-propionibacterium acnes is obtained and compositions for regulating skin microecology.

Embodiment 3

[0052] A composition for resisting Propionibacterium acnes and regulating skin microecology, comprising the following components in parts by weight:

[0053]

[0054] The molecular weight of polylysine is 3600-3800.

[0055] Water is sterilized deionized water.

[0056] Cordycepin is derived from the extract of Cordyceps sinensis.

[0057] The pH regulator is citric acid.

[0058] A preparation method of a composition for resisting Propionibacterium acnes and regulating skin microecology, comprising the following steps:

[0059] (1) Weigh each component according to the formula amount, add the pH regulator into water, adjust the pH to 5.0-5.5, and prepare the mixture for subsequent use;

[0060](2) Add nisin, polylysine, cordycepin, and lysozyme to the mixture prepared in step (1), stir and dissolve until the prepared mixture is transparent, and then the anti-propionibacterium acnes is obtained and compositions for regulating skin microecology.

[0061] Product Effect ...

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Abstract

The invention belongs to the technical field of medical biology and discloses a composition for resisting propionibacterium acnes and regulating skin micro-ecology. The composition comprises the following components (by weight): 0.5-3 parts of nisin, 0.1-2 parts of polylysine, 0.1-2 parts of cordycepin, 0.1-1 part of lysozyme, 10-50 parts of water and 0.5-4 parts of a pH regulator. The compositionhas a remarkable antagonistic effect on the growth of propionibacterium acnes and staphylococcus aureus, and can weaken the film-forming growth of propionibacterium acnes, so that the skin invasiveness of propionibacterium acnes is weakened, the occurrence and development of acnes are intervened, and then the effect of preventing and treating acnes is achieved. According to the composition, the microbial flora on the surface of the skin is regulated to help recover the micro-ecological balance of the skin; and most of the main components of the composition can be degraded into amino acids, sothat a part of nutrient matrix can be provided for skin repair. The composition can be added into a skin micro-ecology regulating preparation, an anti-acne preparation or an acne removing preparation.

Description

technical field [0001] The invention belongs to the technical field of medicine and biology, and in particular relates to a composition for resisting Propionibacterium acnes and regulating skin microecology and its application. Background technique [0002] The skin is the largest organ of the human body. Some microorganisms living on the skin provide ecological protection for the skin. When the skin flora is out of balance, it will cause skin diseases, such as the overgrowth of Propionibacterium acnes, causing acne on the skin. Propionibacterium acnes is a multidrug-resistant bacterium, and its growth is easy to form bacterial film, which is one of the factors of its skin invasiveness, and it is more prone to anaerobic growth and resistance to antibiotics. Usually the treatment of acne adopts drugs such as antibiotics and hormones more, but the effect is not good. [0003] The skin is an ecosystem consisting of ecological niches (microecology) in different parts. About on...

Claims

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Application Information

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IPC IPC(8): A61K38/16A61K31/785A61K31/7076A61K38/47A61P17/10A61P31/04A61P31/10A01N43/90A01N37/46A01N43/50A01N63/50A01P1/00A01P3/00
CPCA61K38/164A61K31/785A61K31/7076A61K38/47C12Y302/01017A61P17/10A61P31/04A61P31/10A01N43/90A01N37/46A01N43/50A01N63/00A61K2300/00
Inventor 周守山何俭邝刘建李盈王伟邹劲峰戴稳平林晓肖炼
Owner 湖州中科金羿医药科技有限公司