Preparation method and application of tricyclohexyltin indole-3-carboxylate complex
A technology of tricyclohexyl and complexes, applied in tin organic compounds, pharmaceutical formulations, organic chemical methods, etc., can solve problems such as application limitation, strong toxicity, etc., and achieve the effects of simple preparation method, low cost, and high anticancer activity
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Embodiment 1
[0033] Preparation of tricyclohexyltin indole-3-carboxylate complex:
[0034] Add 0.3857 g (1 mmol) of tricyclohexyltin hydroxide, 0.1617 g (1 mmol) of indole-3-carboxylic acid, and 10 mL of anhydrous methanol into the microwave reaction tank in sequence. Microwave reaction was performed at 800 W and 100 °C for 60 min. After the reaction, cool naturally, filter, and the solvent volatilizes and crystallizes at room temperature to obtain white crystals, which are tricyclohexyl tin indole-3-carboxylate complexes. Yield: 66%, melting point: 222-225°C.
[0035] Elemental analysis (C27 h 39 NO 2 Sn): theoretical values: C, 61.38; H, 7.44; N, 2.65. Found: C, 61.38; H, 7.43; N, 2.69.
[0036] IR(KBr, v / cm -1 ): 2920.23 (m), 2846.93 (m), 2360.87 (s), 2335.80 (s), 1595.13 (m), 1523.76 (m), 1446.61 (m), 1388.75 (m), 1317.38 (w), 1207.44 (m ), 1122.67 (w), 1037.70 (m), 989.48 (w), 783.10 (w), 742.59 (m), 650.01 (m), 486.06 (m), 420.48 (w).
[0037] 1 H NMR (CDCl 3 , 500 MHz) δ ...
Embodiment 2
[0042] Preparation of tricyclohexyltin indole-3-carboxylate complex:
[0043] Add 0.3846 g (1 mmol) of tricyclohexyltin hydroxide, 0.1693 g (1.05 mmol) of indole-3-carboxylic acid, and 15 mL of anhydrous methanol into the microwave reaction tank in sequence. Microwave reaction was performed at 800 W at 100 °C for 60 min. After the reaction, cool naturally, filter, and the solvent volatilizes and crystallizes at room temperature to obtain white crystals, which are tricyclohexyl tin indole-3-carboxylate complexes. Yield: 67%, melting point: 222-225°C.
[0044] Elemental analysis (C 27 h 39 NO 2 Sn): theoretical values: C, 61.38; H, 7.44; N, 2.65. Found: C, 61.38; H, 7.43; N, 2.69.
[0045] IR(KBr, v / cm -1 ): 2920.23 (m), 2846.93 (m), 2360.87 (s), 2335.80 (s), 1595.13 (m), 1523.76 (m), 1446.61 (m), 1388.75 (m), 1317.38 (w), 1207.44 (m ), 1122.67 (w), 1037.70 (m), 989.48 (w), 783.10 (w), 742.59 (m), 650.01 (m), 486.06 (m), 420.48 (w).
[0046] 1 H NMR (CDCl 3 , 500 MHz)...
Embodiment 3
[0051] Preparation of tricyclohexyltin indole-3-carboxylate complex:
[0052] Add 0.3848 g (1 mmol) of tricyclohexyltin hydroxide, 0.1620 g (1 mmol) of indole-3-carboxylic acid, and 12 mL of anhydrous methanol into the microwave reaction tank in sequence. Microwave reaction was performed at 800 W and 100 °C for 120 min. After the reaction, cool naturally, filter, and the solvent volatilizes and crystallizes at room temperature to obtain white crystals, which are tricyclohexyl tin indole-3-carboxylate complexes. Yield: 68%, melting point: 222-225°C.
[0053] Elemental analysis (C 27 h 39 NO 2 Sn): theoretical values: C, 61.38; H, 7.44; N, 2.65. Found: C, 61.38; H, 7.43; N, 2.69.
[0054] IR(KBr, v / cm -1 ): 2920.23 (m), 2846.93 (m), 2360.87 (s), 2335.80 (s), 1595.13 (m), 1523.76 (m), 1446.61 (m), 1388.75 (m), 1317.38 (w), 1207.44 (m ), 1122.67 (w), 1037.70 (m), 989.48 (w), 783.10 (w), 742.59 (m), 650.01 (m), 486.06 (m), 420.48 (w).
[0055] 1 H NMR (CDCl 3 , 500 MHz) ...
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