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Novel chlorine-containing carboxylic acid metal complex, and preparation method and application thereof

A technology of metal complexes and chlorocarboxylic acids, applied in the direction of 1/11 organic compounds without C-metal bonds, copper organic compounds, organic chemical methods, etc., can solve the problems of large toxic and side effects, hindered use, and strong drug resistance and other problems, to achieve the effect of low equipment requirements, simple preparation method, and induction of apoptosis

Active Publication Date: 2020-12-25
GUANGXI NORMAL UNIV FOR NATITIES
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In recent years, the medicinal value of metal complexes has been gradually discovered and applied clinically, but the clinical use of platinum-based metal drugs has been hindered due to their high toxicity, side effects, and strong drug resistance. , looking for new metal complexes as anticancer drugs has become a hot research field

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  • Novel chlorine-containing carboxylic acid metal complex, and preparation method and application thereof
  • Novel chlorine-containing carboxylic acid metal complex, and preparation method and application thereof
  • Novel chlorine-containing carboxylic acid metal complex, and preparation method and application thereof

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preparation example Construction

[0038] In some embodiments of the present invention, a method for preparing the above-mentioned novel chlorocarboxylic acid metal complexes is also provided, comprising the following steps: 2-chloro-5-nitrobenzoic acid, 2-amino-6-methoxybenzene And thiazole is dissolved in the solvent, stirred and dissolved to make a mixed solution; copper nitrate is dissolved in the solvent, stirred and dissolved to obtain a copper nitrate solution, and the copper nitrate solution is added dropwise to the mixed solution. After the drop is completed, adjust the pH at 5-7 In between, stir and react at room temperature for a period of time, seal the film and place it in a cool place, and after standing for 12-28d, brown blocky crystals are precipitated.

[0039] In order to fully react the ligand raw materials and obtain the target complex, the molar ratio of the 2-chloro-5-nitrobenzoic acid, 2-amino-6-methoxybenzothiazole and copper nitrate is 9:3:1.5 -2.

[0040] In order to make the raw mate...

Embodiment 1

[0046]Synthesis of the complex: Dissolve 2-chloro-5-nitrobenzoic acid (0.9mmol) and 2-amino-6-methoxybenzothiazole (0.3mmol) in 5ml of methanol, stir and dissolve to make a mixed solution; Dissolve copper nitrate (0.15mmol) in 10ml of methanol solvent, stir and dissolve to obtain a copper nitrate solution, add the copper nitrate solution dropwise to the mixed solution within 20min, the solution appears yellow-green, after the addition is complete, use 1.0mol L -1 The NaOH solution adjusted the pH to 5, stirred and reacted at room temperature for 20 minutes, sealed the film and placed it in a cool place, and after standing for 12 days, brown blocky crystals were precipitated.

Embodiment 2

[0048] Synthesis of the complex: Dissolve 2-chloro-5-nitrobenzoic acid (0.9mmol) and 2-amino-6-methoxybenzothiazole (0.3mmol) in 5ml of methanol, stir and dissolve to make a mixed solution; Dissolve copper nitrate (0.18mmol) in 10ml of methanol solvent, stir and dissolve to obtain a copper nitrate solution, add the copper nitrate solution dropwise to the mixed solution within 30min, the solution appears yellow-green, after the addition is complete, use 1.0mol·L -1 The NaOH solution adjusted the pH to 6, stirred and reacted at room temperature for 30 minutes, sealed the film and placed it in a cool place, and after standing for 20 days, tan massive crystals were precipitated.

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Abstract

The invention provides a novel chlorine-containing carboxylic acid metal complex, and a preparation method and application thereof, and belongs to the technical field of medicine synthesis. The coordination structure diagram of the metal complex is shown in Figure 1. The preparation method of the novel chlorine-containing carboxylic acid metal complex comprises the following steps: dissolving 2-chloro-5-nitrobenzoic acid and 2-amino-6-methoxy benzothiazole in a solvent, and stirring for dissolving to prepare a mixed solution; and dissolving copper nitrate in a solvent, stirring for dissolvingto obtain a copper nitrate solution, dropwise adding the copper nitrate solution into the mixed solution, adjusting the pH value to be 5-7 after the copper nitrate solution is completely dropwise added, stirring and reacting for a period of time at room temperature, sealing with a film, putting the sealed solution in a shade place, and standing for 12-28 days to precipitate dark brown blocky crystals. The metal complex provided by the invention has good anti-cancer activity, and the preparation method is simple.

Description

technical field [0001] The invention relates to the technical field of drug synthesis, in particular to a novel chlorocarboxylic acid metal complex, its preparation method and application. Background technique [0002] Deoxyribonucleic acid (DNA) is an important carrier of life genetic information and participates in the expression process of genetic information in cells. DNA is the target molecule of many drugs. Studying the interaction between drugs and DNA will help to understand the medicinal mechanism of drug molecules and provide a theoretical basis for the design and development of new drugs. Metal complexes have potential applications in the field of biomedicine. Therefore, establishing an in vitro model of metal complexes binding to DNA, and studying the binding mode, binding site, and interaction between the two are very important for the design and in vitro screening of antitumor drugs. Significance. [0003] HSA is an abundant carrier protein in the human circu...

Claims

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Application Information

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IPC IPC(8): C07F1/08A61P35/00
CPCC07F1/005A61P35/00C07B2200/13Y02A50/30
Inventor 曾振芳黄秋萍韦友欢蔡杰慧李致宝张海全覃丽金韦士铮
Owner GUANGXI NORMAL UNIV FOR NATITIES
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