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Herbal compositions with improved bioavailability

A composition and utilization technology, applied in the directions of iodine compound active ingredient, heterocyclic compound active ingredient, hydroxyl compound active ingredient, etc., can solve the problems of reduced usefulness, low bioavailability, etc., achieve fast time and improve subjective curative effect , quick-acting effect

Inactive Publication Date: 2020-05-15
RECEPTOR HLDG INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Despite the many health benefits associated with many plants and plant extracts, their active ingredients can have low bioavailability when ingested orally, reducing their usefulness in some cases

Method used

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  • Herbal compositions with improved bioavailability
  • Herbal compositions with improved bioavailability
  • Herbal compositions with improved bioavailability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0239] Example 1. Exemplary formulation. Solution formulation. Combine a vegetable substance (for example, a plant extract or a plant active ingredient such as curcumin) and one or more N-acylated fatty amino acids in an aqueous / organic solvent mixture. The resulting blend was stirred vigorously for one hour. If the dissolution is not complete, the surfactant can be added and stirring can be continued to prepare the final formulation.

[0240] Suspension formulation. Combine plant substances (for example, plant extracts or plant active components such as curcumin) and one or more N-acylated fatty amino acids in water, an aqueous / organic solvent mixture, or an organic solvent mixture. The resulting blend can be stirred to achieve suspension.

[0241] Solution formulation. Combine plant substances (for example, plant extracts or plant active ingredients such as curcumin) and one or more absorption enhancers in an aqueous / organic solvent mixture. The resulting blend was stirred...

Embodiment 2

[0245] Example 2. Action time and duration of action of the orally administered cannabis / SNAC composition. This study is designed to evaluate the utility of SNAC in achieving the rapid-acting oral form of the herbal composition.

[0246] Participant's choice. Six study participants were recruited to take the herbal composition and recorded the start time, duration and intensity of the euphoria and / or irritability induced by cannabis in this example. The study participants participated in two separate tests: 1) the use of control substances, which included liquid cannabis extract dissolved in aqueous ethanol, and 2) the use of test substances, which included liquid cannabis extract dissolved in aqueous ethanol and SNAC.

[0247] preparation. The selected cannabis concentrates are commercially available and provided to participants as ethanol solutions. The concentrate contains 8 mg THC per dose. This concentrate was chosen because it contains a high percentage of THC, which has...

Embodiment 3

[0264] Example 3. Action time and duration of action of herbal composition / SNAC composition administered orally at a low SNAC dose. This study was designed to evaluate the utility of the oral form of SNAC that achieves rapid action of herbal composition at low doses.

[0265] Participant's choice. Three study participants were recruited to take the herbal composition and record the onset, duration, and intensity of the euphoria and / or irritability induced by cannabis. Study participants participated in two separate tests: 1) the use of a control substance, which included liquid hemp extract dissolved in an aqueous ethanol solution, and 2) the use of a test substance, which included liquid hemp extract dissolved in an aqueous ethanol solution, and SNAC .

[0266] preparation. The selected cannabis concentrates are commercially available and provided to participants as ethanol solutions. The concentrate contains 8 mg THC per dose. This concentrate was chosen because it contains...

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Abstract

Herbal compositions in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and / or various other beneficial carriers. The herbal composition / carrier combinations can create administration benefits.

Description

[0001] Cross references to related applications [0002] This application claims the priority of 62 / 568,678 filed on October 5, 2017, and 62 / 568,678 is incorporated herein by reference in its entirety, as if it were fully described herein. Technical field [0003] The present disclosure provides herbal compositions with improved bioavailability in various carrier combinations. The carrier may include N-acylated fatty amino acids, penetration enhancers and / or various other beneficial carriers. The herbal composition / carrier combination can produce administration benefits after oral administration. Background technique [0004] Historically, the plant world has been the most important source of medicinal agents for the treatment of human and animal diseases, as well as preventive agents for maintaining good health. However, for at least the past 150 years, Western medicine has been dominated by synthetic chemical reagents. [0005] However, it is now increasingly recognized that many...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/18A61K36/88A61K36/906
CPCA23L33/105A23L33/15A23L33/17A61K9/0056A61K9/0095A61K9/08A61K9/10A61K9/4858A61K31/07A61K31/122A61K31/20A61K31/355A61K31/375A61K31/4415A61K31/51A61K31/525A61K31/59A61K31/714A61K33/06A61K33/18A61K33/26A61K33/30A61K36/185A61K36/36A61K36/481A61K36/51A61K36/53A61K36/575A61K36/61A61K36/752A61K36/81A61K36/9066A61K47/12A61K47/14A61K47/183A61K9/0058
Inventor A·莱昂内-贝G·韦斯纳
Owner RECEPTOR HLDG INC