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Porcine immunoglobulin oral liquid

A technology of immunoglobulin and oral liquid, which is applied in the field of protein oral liquid, can solve the problems of single ingredient, high cost, and difficult to obtain materials, and achieve the effect of wide source, low cost, and less allergy

Pending Publication Date: 2020-05-19
昆明白马制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Human gamma balls, which are routinely used, have a single component, mainly IgG, and very little IgM content. Materials derived from human blood are not easy to obtain, and the cost is high. Blood products are administered by injection, and have become The main route of blood-borne infection, so there is a need for an anti-infection immune preparation that can be administered orally, has a wide range of raw materials, and is low in cost

Method used

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  • Porcine immunoglobulin oral liquid

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Effect test

Embodiment 1

[0032] The invention provides a porcine immunoglobulin oral liquid, which contains complex immunoglobulins extracted from porcine serum and containing rotavirus-specific neutralizing antibodies, including IgG, IgM and IgA.

[0033] The preparation concrete steps of porcine immunoglobulin oral liquid are as follows:

[0034] S1. Pig plasma collection: collect 50Kg of whole blood from 30 pigs, then add 4% sodium citrate anticoagulant 3.125Kg to the whole blood and stir evenly to prevent blood coagulation, then put the whole blood into a centrifuge Centrifuged at 6000r / min, centrifuged for 20min, centrifuged to obtain a serum volume of 20.75Kg;

[0035] S2, component separation:

[0036] S2.1, add 14.53Kg of distilled water to the obtained 20.75Kg of pig plasma for dilution, then add 13.49Kg of 3% rivanol solution and 10.38ml of caprylic acid and stir evenly, then add 100ml of glacial acetic acid and stir for 30min, mix The pH of the solution was adjusted to 7.0, and then put i...

Embodiment 2

[0049] The invention provides a porcine immunoglobulin oral liquid, which contains complex immunoglobulins extracted from porcine serum and containing rotavirus-specific neutralizing antibodies, including IgG, IgM and IgA.

[0050] The preparation concrete steps of porcine immunoglobulin oral liquid are as follows:

[0051] S1. Pig plasma collection: collect 50Kg of whole blood from 30 pigs, then add 4% sodium citrate anticoagulant 3.125Kg to the whole blood and stir evenly to prevent blood coagulation, then put the whole blood into a centrifuge Centrifuged at 6000r / min, centrifuged for 20min, centrifuged to obtain a serum volume of 20.75Kg;

[0052] S2, component separation:

[0053] S2.1, add 14.53Kg of distilled water to the obtained 20.75Kg of pig plasma for dilution, then add 13.49Kg of 3% rivanol solution and 10.38ml of caprylic acid and stir evenly, then add 100ml of glacial acetic acid and stir for 30min, mix The pH of the solution was adjusted to 7.1, and then put i...

Embodiment 3

[0066] The invention provides a porcine immunoglobulin oral liquid, which contains complex immunoglobulins extracted from porcine serum and containing rotavirus-specific neutralizing antibodies, including IgG, IgM and IgA.

[0067] The preparation concrete steps of porcine immunoglobulin oral liquid are as follows:

[0068] S1. Pig plasma collection: collect 50Kg of whole blood from 30 pigs, then add 4% sodium citrate anticoagulant 3.125Kg to the whole blood and stir evenly to prevent blood coagulation, then put the whole blood into a centrifuge Centrifuged at 6000r / min, centrifuged for 20min, centrifuged to obtain a serum volume of 20.75Kg;

[0069] S2, component separation:

[0070] S2.1, add 14.53Kg of distilled water to the obtained 20.75Kg of pig plasma for dilution, then add 13.49Kg of 3% rivanol solution and 10.38ml of caprylic acid and stir evenly, then add 100ml of glacial acetic acid and stir for 30min, mix The pH of the solution was adjusted to 7.2, and then put i...

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Abstract

The embodiment of the invention discloses a porcine immunoglobulin oral liquid, and particularly relates to the technical field of protein oral liquid. The oral liquid contains composite immunoglobulins which are extracted from porcine serum and contain rotavirus specific neutralizing antibodies, and the composite immunoglobulins comprise IgG, IgM and IgA. The oral liquid has an agglutination effect on various bacteria, and the agglutination activity is similar to that of human gamma globulin. The oral liquid has a good treatment effect on infection models of dysentery bacillus and pseudomonasaeruginosa of mice, has an antiviral effect of inhibiting cytopathy on human rotavirus infected cell strains, is not damaged by gastric juice, is stable in intestines for more than 6 hours, sufficiently exerts the drug effect, is administrated in an oral administration manner, does not cause blood-borne infection worry, is not easy to cause allergy after oral administration, has a wide source andlow cost, and is an ideal anti-infective immune preparation.

Description

technical field [0001] The embodiment of the present invention relates to the technical field of protein oral liquid, in particular to a porcine immunoglobulin oral liquid. Background technique [0002] Although the content of IgG in pig serum is lower than that of human serum, the content of IgM in pig serum is 3.9 times higher than that of human, and the content of IgA is 1.65 times higher than that of human. The latter two types of immunoglobulins can accept secretory tablets, which are Synthesized by mucosal epithelial cells, it can protect globulins from hydrolysis and damage by various proteases, especially IgM, which has the highest immune activity among the five types of Ig, and has the strongest cohesion and complement binding ability. One IgM molecule binds to an antigen After that, complement can be activated, and IgG needs at least two or more molecules to bind to the antigen to activate complement. The aggregation effect of IgM is 20 times greater than that of ...

Claims

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Application Information

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IPC IPC(8): A61K39/42A61K9/08A61K47/26A61P31/04A61P31/14C07K16/06C07K16/10C07K1/36C07K1/30C07K1/34
CPCA61K39/42A61K9/08A61K9/0053A61K47/26A61P31/04A61P31/14C07K16/065C07K16/10A61K2039/507Y02A50/30
Inventor 不公告发明人
Owner 昆明白马制药有限公司
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