Preparation method of anti-bone tumor composite material stent

A composite material and bone tumor technology, applied in the field of the preparation of composite material scaffolds, can solve the problems of local inflammatory response, poor mechanical strength, weak cell adhesion, etc., achieve high impact strength and hardness, reduce burden, and avoid sudden release Effect

Pending Publication Date: 2020-06-02
YANGZHOU UNIV
View PDF9 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantages of PLA materials include poor mechanical strength, insufficient hydrophilicity, weak adhesion to cells, and acidic products after degradation can easily cause local inflammatory reactions in the body, which is not conducive to the growth of bone cells, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of anti-bone tumor composite material stent
  • Preparation method of anti-bone tumor composite material stent
  • Preparation method of anti-bone tumor composite material stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (MTX mass ratio is 1%, MTX-PLA / HA composite bone repair scaffold)

[0033] Preparation of hydroxyapatite by co-precipitation method: 185.4g of calcium chloride and 380g of sodium phosphate dodecahydrate were dissolved in 1L of water respectively. Under the condition of 90℃ water bath and stirring, add the sodium phosphate solution to the calcium chloride solution, adjust the pH to 9~11 with sodium hydroxide solution and hydrochloric acid, and keep stirring for 4 hours. Stand still and age for 12 hours. After aging, wash to remove the by-product sodium chloride, and dry to obtain nano-sized hydroxyapatite.

[0034] Methotrexate powder, hydroxyapatite powder and PLA powder were sieved through 200 meshes respectively. The weight content of methotrexate (MTX) in the mixed raw material is 1%, the weight content of nanoscale hydroxyapatite powder in the mixed raw material is 10%, and the balance is PLA powder. The mixture was added to an internal mixer and mixed for 10 min...

Embodiment 2

[0037] (MTX mass ratio is 0.1%, MTX-PLA / HA composite bone repair scaffold)

[0038] The difference from Example 1 is that the weight content of methotrexate (MTX) in the mixed raw material is 0.1%, and the weight content of nanoscale hydroxyapatite powder in the mixed raw material is 9%.

Embodiment 3

[0040](MTX mass ratio is 5%, MTX-PLA / HA composite bone repair scaffold)

[0041] The difference from Example 1 is that the weight content of methotrexate (MTX) in the mixed raw material is 5%, and the weight content of nanoscale hydroxyapatite powder in the mixed raw material is 11%.

[0042] In the above examples, the specific dosage of methotrexate needs to be regulated according to the patient's own condition and doctor's order.

[0043] figure 1 It is a sample picture of the MTX-PLA / HA composite anti-tumor scaffold. It can be seen that the voids in the anti-tumor scaffold have a pore size of about 300 microns. The existence of porous voids accelerates the degradation of polylactic acid in the human body and reduces the drug release rate. difficulty. And the existence of pores provides convenience for the later generation of new bone. The stent sample is not limited to the disc shape, and the specific shape can be adjusted by itself according to the CT data.

[0044] ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
lengthaaaaaaaaaa
pore sizeaaaaaaaaaa
Login to view more

Abstract

The present invention discloses a preparation method of an anti-bone tumor composite material stent in the technical field of medical orthopedic materials. The preparation method is as follows: uniformly mixing methotrexate powder, nano-grade hydroxyapatite powder and medical-grade polylactic acid powder; extruding out the mixture into wire through a screw extruder; and then using a 3D printer forprinting to obtain the anti-bone tumor composite material stent. The stent can slowly release drugs in body to inhibit growth of cancer cells and besides, the stent has mechanical properties matchingwith cancellous bones.

Description

technical field [0001] The invention belongs to the technical field of medical orthopedic materials, and in particular relates to a preparation method of a composite material bracket for resisting bone tumors. Background technique [0002] Osteosarcoma is the most common type of bone malignancy, and it is a disease with a high mortality rate of malignant tumors in children and adolescents. It is developed from the mesenchymal cell line, and the rapid growth of the tumor is due to the direct or indirect formation of tumor osteoid tissue and bone tissue through the cartilage stage of the tumor. Common osteosarcomas originate in bone or connective tissue. The latter is less common and has a better prognosis. [0003] After the pathological diagnosis of osteosarcoma, the initial chemical or radiotherapy begins. Excision of tumor tissue is an important step in the treatment of osteosarcoma. After resection of tumor tissue, postoperative chemotherapy or radiotherapy is required...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/18A61L27/50A61L27/54A61L27/56A61L27/58B33Y70/10B33Y80/00
CPCA61L27/12A61L27/18A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/416A61L2300/604A61L2430/02B33Y70/00B33Y80/00C08L67/04
Inventor 朱沛志梅宇程
Owner YANGZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap