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Stable cannabinoid compositions

A technology of cannabinoids and compositions, applied in the field of compositions containing lipophilic bioactive compounds, which can solve the problems of low potency, exacerbation, and reduced availability of ingredients in emulsions, and achieve high use, high potency, and enhanced light resistance and/or the effect of thermal degradation stability

Pending Publication Date: 2020-06-02
SOLMIC BIOTECH GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these emulsions may also have low potency due to their instability in the intestinal tract, where the emulsion can "break" due to dilution below the critical micelle concentration, and thus destabilize the micellar formulation
[0009] The above-mentioned problems are further exacerbated in liquid or gel-like formulations, which in most cases exhibit insufficient shelf-life, because when compared to solid forms (such as lozenges or capsules), due to light and oxygen exposure, the Degradation of emulsified ingredients further reduces the availability of ingredients in the emulsion

Method used

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  • Stable cannabinoid compositions
  • Stable cannabinoid compositions
  • Stable cannabinoid compositions

Examples

Experimental program
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Effect test

Embodiment

[0064] 4 parts by weight of the first poloxamer (can be P 188 commercially available from BASF Germany) and 16 parts by weight of a second poloxamer (available under the trade name P 407 commercially available from BASF Germany) was combined in a beaker and heated to a temperature of 70 to 80°C until a first colorless transparent melt was formed. Subsequently, 1 part by weight of DL-alpha-tocopherol (commercially available from BASF Germany) was added to the first melt while maintaining the temperature at 70 to 80°C until a second yellow transparent melt was formed. Subsequently, 1 part by weight of cannabidiol as a natural extract was added to the second melt while maintaining the temperature at 70 to 80° C. until the cannabidiol was dissolved, thereby forming a third transparent melt. Then, 88 parts by weight of an aqueous solution containing 0.1 part by weight of potassium sorbate and 0.05 part by weight of citric acid was preheated to a temperature of 70 to 80° C. and a...

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Abstract

A composition comprising a cannabinoid, in particular a phytocannabinoid or a synthetic cannabinoid, wherein the cannabinoid is stabilised against oxidation and / or photochemical degradation, characterized in that the composition comprises a micellar solution of poloxamer-based micelles in an aqueous solution and where the poloxamer micelles encapsulate the cannabinoid.

Description

technical field [0001] The present invention relates to compositions comprising lipophilic bioactive compounds, such as cannabinoids, wherein the cannabinoids are stabilized against oxidative and / or photochemical degradation. Background technique [0002] Pharmaceutical formulations allow active ingredients to enter the body and reach target tissues so that they can perform their intended effects in the body. When an active ingredient must be administered via a given route, the physical and chemical properties of the active ingredient and its formulation should be fully considered. [0003] For example, the ability of an active ingredient to be taken up through the gut via the oral route, ie to enter the systemic circulation, depends largely on its stability to acid (gastric juice), enzymatic degradation (eg pancreatic enzymes) and water solubility. [0004] Likewise, uptake through the skin depends on the ability of the active ingredient to bypass the upper skin layer cons...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/10A61K47/22A61K31/05A61K31/352
CPCA61K9/1075A61K31/05A61K31/352A61K47/10A61K47/22A61K9/0014A61K9/0053
Inventor 伊尔莎·克内勒托马斯·佐维克
Owner SOLMIC BIOTECH GMBH
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