Application of micromolecule oligopeptide for preparing medicine capable of treating psoriasis
A small molecule, psoriasis technology, applied in the field of psoriasis drug R&D and preparation, can solve the problems of patients with large systemic and local side effects, unclear pathogenesis of psoriasis, no treatment method, etc. Skin manifestations, effects with little impact
Inactive Publication Date: 2020-06-09
PEKING UNIV
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Problems solved by technology
[0004] Because the specific pathogenesis of psoriasis is still unclear, there is no effective treatment method at present. The use of hormone therapy has great systemic and local side effects on patients. Although simple antiallergic drugs can relieve symptoms, they have no effect because they cannot solve the fundamental problem. very limited
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Embodiment 1
[0019] Buy F991 emulsifiable paste, composition is: water, petrolatum, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, F991 (7.5% mass percent).
[0020] In the above-mentioned creams, Vaseline mainly plays the role of excipient and prolongs the action time of active pharmaceutical ingredients; sodium chloride, disodium hydrogen phosphate and sodium dihydrogen phosphate are used to maintain the ion concentration and pH value of active pharmaceutical ingredients; The active ingredient is a small molecule oligopeptide, the amino acid sequence is: AHWSGHCCL (SEQ ID NO.1), which inhibits the inflammatory response by inhibiting the deposition of free light chains of immunoglobulins; water is used as a solvent.
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The invention discloses application of micromolecule oligopeptide for preparing a medicine capable of treating psoriasis. The amino acid sequence of the micromolecule oligopeptide is AHWSGHCCL, and the micromolecule oligopeptide can obviously alleviate the skin feature of the psoriasis only through external-application smearing for medicine administration. In addition, after a micromolecule medicine is absorbed to act, the micromolecule medicine can be easily degraded and metabolized, the anti-inflammatory mechanism of the micromolecule medicine is different from an existing hormone cream, anda side effect is very small; and finally, external-application medicine administration obviously locally acts but slightly affects the whole body.
Description
technical field [0001] The invention relates to the technical field of research, development and preparation of psoriasis drugs, in particular to the application of a small molecule oligopeptide in the preparation of drugs for treating psoriasis. Background technique [0002] Psoriasis is an immune-mediated chronic, relapsing, inflammatory, and systemic disease. Typical clinical manifestations are scaly erythema or plaques, limited or widespread distribution, non-infectious, difficult to treat, and often lifelong. [0003] The etiology of psoriasis involves multiple factors such as genetics, immunity, and environment. The immune response mediated mainly by T lymphocytes and participated by a variety of immune cells causes excessive proliferation of keratinocytes or the formation of joint synoviocytes and chondrocytes. inflammation. [0004] Because the specific pathogenesis of psoriasis is still unclear, there is no effective treatment method at present. The use of hormone ...
Claims
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IPC IPC(8): A61K38/08A61K9/06A61P17/06
CPCA61K9/0014A61K9/06A61K38/08A61P17/06
Inventor 戴慧邱晓彦谢嘉伟
Owner PEKING UNIV