Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition containing JAK3/JAK1/TBK1 inhibitor and methotrexate and application thereof

A technology of methotrexate and its composition, which is applied in the field of medicine, can solve the problems of reducing drug tolerance, reducing the dose of a single drug, etc., and achieve the effects of reducing drug tolerance, reducing adverse reactions, and good drug selection

Active Publication Date: 2020-06-19
CHENGDU CHIPSCREEN PHARM LTD
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research on the combined application of the two in the treatment of RA and other autoimmune diseases. The present invention combines these two drugs with different mechanisms, and unexpectedly finds that the two have a significant synergistic effect on RA, which can reduce the Single drug dose, reduce patient drug tolerance and reduce possible adverse reactions provide new and better medication options

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition containing JAK3/JAK1/TBK1 inhibitor and methotrexate and application thereof
  • Pharmaceutical composition containing JAK3/JAK1/TBK1 inhibitor and methotrexate and application thereof
  • Pharmaceutical composition containing JAK3/JAK1/TBK1 inhibitor and methotrexate and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0061] The present invention discloses the combination of MTX or its pharmaceutically acceptable salts and JAK3 / JAK1 / TBK1 inhibitors and its use in the treatment of autoimmune diseases including RA. Those skilled in the art can learn from the content of this article and appropriately improve the process parameter implementation. In particular, it should be pointed out that all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included within the scope of the present invention. This section is intended to describe the preferred embodiments of the applications and pharmaceutical compositions of the present invention, and relevant personnel can obviously make changes or modifications to the applications and pharmaceutical compositions described herein without departing from the content, spirit and scope of the present invention. Appropriate changes and combinations are used to realize and apply the technology of the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a pharmaceutical composition containing a JAK3 / JAK1 / TBK1 inhibitor and methotrexate or a pharmaceutically acceptable salt thereof and application thereof, and particularly relates to application of the combination of a JAK3 / JAK1 / TBK1 inhibitor and methotrexate in treatment of autoimmune diseases, especially rheumatoid arthritis. According to the combined medication scheme provided by the invention, the curative effect is increased through the synergistic effect of the medicines, so that the dosage of a single medicine is reduced, the toxicity is reduced, the medicine tolerance of a patient is reduced, possible adverse reactions are reduced, and a new better medication choice is expected to be provided for autoimmune diseases including RA.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a drug combination comprising a JAK3 / JAK1 / TBK1 inhibitor and methotrexate and its use and method in treating autoimmune diseases, especially rheumatoid arthritis. Background technique [0002] Autoimmune diseases refer to the diseases caused by the body's immune response to self-antigens, resulting in damage to its own tissues. Common autoimmune diseases include rheumatoid arthritis, psoriasis, Crohn's disease, systemic lupus erythematosus, Multiple sclerosis, type 1 diabetes, allergic diseases, chronic obstructive pulmonary disease, asthma, leukemia, lymphoma diseases, etc. [0003] Rheumatoid arthritis (RA) is a chronic, autoimmune disease characterized by polyarticular, symmetrical, aggressive synovial inflammation of the joints and possible involvement of extra-articular organs. The cause of the disease is unknown, and the peak age of onset is between 30 and 50 y...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/519A61K31/505A61P37/02A61P19/02A61P37/08A61P9/10A61P3/10A61P11/00A61P11/06A61P35/00A61P35/02
CPCA61K31/519A61K31/505A61P37/02A61P19/02A61P37/08A61P9/10A61P3/10A61P11/00A61P11/06A61P35/00A61P35/02A61K2300/00
Inventor 方征宇鲁先平王庆文周游山松虎义平钟福波何娟戴嘉婧
Owner CHENGDU CHIPSCREEN PHARM LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com