Method for preparing hydroxyapatite ceramic through combination of microwave hydrothermal method and microwave sintering method

A technology of hydroxyapatite and microwave hydrothermal method, which is applied in medical science, prosthesis, tissue regeneration, etc., can solve the problem of poor mechanical properties of hydroxyapatite ceramics, abnormal growth of crystal grains, and low bending strength. Advanced problems, to achieve the effect of shortening sintering time, high density and short reaction time

Inactive Publication Date: 2020-06-23
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Hydroxyapatite ceramics have excellent biocompatibility and osteoinductivity, and can be directly implanted into the human body as surgical implant materials to repair damaged hip joints and other bone tissues in the human body. However, the mechanical properties of hydroxyapatite ceramics Poor, low bending strength, difficult to be widely used in load-bearing joints
[0004] Xu Yubin from South China University of Technology (Xu Yubin. Preparation of highly bioactive hydroxyapatite ceramics and its properties by infiltration and coating modification

Method used

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  • Method for preparing hydroxyapatite ceramic through combination of microwave hydrothermal method and microwave sintering method
  • Method for preparing hydroxyapatite ceramic through combination of microwave hydrothermal method and microwave sintering method

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Embodiment 1

[0018] Dissolve 14.32 g of disodium hydrogen phosphate and 9.8 g of calcium chloride dihydrate in 100 mL of pure water, respectively, and stir magnetically for about 20 minutes until the samples are completely dissolved to obtain disodium hydrogen phosphate aqueous solution and calcium chloride aqueous solution. Slowly spray the prepared calcium chloride aqueous solution into the disodium hydrogen phosphate aqueous solution by ultrasonic spraying method, the rotating speed of the magnetic stirrer is 5 r / min, and the liquid spraying speed is 10 mL / min. During the ultrasonic spraying process, ammonia water was continuously added dropwise to the reaction solution, and the pH of the mixed solution was adjusted to keep it at about 10. The mixed reaction solution was placed in a microwave reactor for reaction, the heating rate was set at 10°C / min, the reaction temperature was 160°C, and the holding time was 40min. After the reaction was completed, the hydroxyapatite solution was obt...

Embodiment 2

[0022] Dissolve 14.32 g of disodium hydrogen phosphate and 9.8 g of calcium chloride dihydrate in 100 mL of pure water, respectively, and stir magnetically for about 20 minutes until the samples are completely dissolved to obtain disodium hydrogen phosphate aqueous solution and calcium chloride aqueous solution. Slowly spray the prepared calcium chloride aqueous solution into the disodium hydrogen phosphate aqueous solution by ultrasonic spraying method, the rotating speed of the magnetic stirrer is 5 r / min, and the liquid spraying speed is 10 mL / min. During the ultrasonic spraying process, ammonia water was continuously added dropwise to the reaction solution, and the pH of the mixed solution was adjusted to keep it at about 10. The mixed reaction solution was placed in a microwave reactor for reaction, the heating rate was set at 10°C / min, the reaction temperature was 160°C, and the holding time was 40min. After the reaction was completed, the hydroxyapatite solution was obt...

Embodiment 3

[0025] Dissolve 14.32 g of disodium hydrogen phosphate and 9.8 g of calcium chloride dihydrate in 100 mL of pure water, respectively, and stir magnetically for about 20 minutes until the samples are completely dissolved to obtain disodium hydrogen phosphate aqueous solution and calcium chloride aqueous solution. Slowly spray the prepared calcium chloride aqueous solution into the disodium hydrogen phosphate aqueous solution by ultrasonic spraying method, the rotating speed of the magnetic stirrer is 5 r / min, and the liquid spraying speed is 10 mL / min. During the ultrasonic spraying process, ammonia water was continuously added dropwise to the reaction solution, and the pH of the mixed solution was adjusted to keep it at about 10. The mixed reaction solution was placed in a microwave reactor for reaction, the heating rate was set at 10°C / min, the reaction temperature was 160°C, and the holding time was 40min. After the reaction was completed, the hydroxyapatite solution was obt...

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Abstract

The invention relates to a method for preparing hydroxyapatite ceramic by combining a microwave hydrothermal method and a microwave sintering method. The method comprises the following steps: firstly,mixing a calcium chloride water solution with a disodium hydrogen phosphate water solution through an ultrasonic spraying method, then transferring the mixed solution into a microwave reactor to carry out reactions to obtain nano scale hydroxyapatite powder, finally, pressing the powder into a green body, and carrying out microwave sintering molding. By adopting the method, the hydroxyapatite powder with good dispersity and high crystallinity can be rapidly prepared in a large scale in a short time, the sintering temperature is reduced, the sintering time is shortened in the sintering process, the grain growth is effectively inhibited, and the prepared ceramic has higher strength and better performance.

Description

technical field [0001] The invention relates to the technical field of inorganic non-metallic materials, in particular to a method for preparing hydroxyapatite ceramics by combining a microwave hydrothermal method and a microwave sintering method. Background technique [0002] Hydroxyapatite is an excellent biomedical material with good biocompatibility and is the main component of human bones and teeth. Since the 1970s, artificially synthesized hydroxyapatite materials began to be gradually applied to the repair of human hard tissue injuries. In the late 1970s, hydroxyapatite was used as a root implant material in dental restorations. In the 1990s, researchers began to use Focus on the mechanical properties and osteoinductivity of hydroxyapatite ceramics. As a bone repair material, hydroxyapatite can be made into various forms of bone repair materials according to the severity of the damaged part and the shape of the bone defect, such as nanoparticles, dense ceramics, micr...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/622C04B35/626C04B35/64A61L27/12A61L27/10A61L27/50
CPCA61L27/10A61L27/12A61L27/50A61L2430/02C04B35/447C04B35/622C04B35/626C04B35/64C04B2235/3208C04B2235/6562C04B2235/6567C04B2235/667C04B2235/96
Inventor 王欣宇陈正雄
Owner WUHAN UNIV OF TECH
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