Barrier membrane for guided bone regeneration and its preparation method

A technology for guiding bone regeneration and barrier membrane, which is applied in the field of barrier membrane for guided bone regeneration and its preparation, can solve the problems of reducing the difficulty of surgery and postoperative risk, being unsuitable for taking a large number of materials, shortening the operation time, etc., so as to shorten the operation time. , the effect of breaking through limitations and reducing postoperative risks

Active Publication Date: 2022-01-11
NEO MODULUS SUZHOU MEDICAL SCI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PRF needs to draw the patient's blood, so it is not suitable for a large number of materials, and the existing centrifugation methods and equipment limit the production of PRF with a small area, which is difficult to apply in large-scale defects, and the operation time is relatively long
In addition, the above-mentioned autologous tissue transplantation is limited, and it will cause additional pain to the patient, and it also has high requirements for the doctor's technical level, and the chair time is longer.
[0004] Therefore, the development of a barrier membrane for guided bone regeneration and its preparation method, in order to avoid the problem of limited materials for autologous tissue transplantation, is not limited by materials, and at the same time shortens the operation time, reduces the difficulty of operation and postoperative risk, obviously has positive practical significance

Method used

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  • Barrier membrane for guided bone regeneration and its preparation method

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Comparison scheme
Effect test

Embodiment 1

[0049] A method of preparing a barrier membrane for guided bone regeneration, comprising the steps of:

[0050] (1) Preparation of gelatin solution

[0051] a, dissolving liquid configuration:

[0052] Was dissolved in purified water accounting for 35wt%, the proportion of acetic acid 25wt%, butyl acetate accounting for 40wt%;

[0053] B, and gelatin was dissolved at a mass ratio of 1: 8 ratio were mixed to dissolve, to obtain complete dissolution of the gelatin solution; the gelatin is a bovine gelatin, gel strength in the range of 180 bloom g;

[0054] (2) Preparation of gelatin fiber membrane

[0055] The prepared solution was added to the gelatin with glutaraldehyde, a crosslinking agent proportion of 0.5wt%, Mix well and injecting the solution into the electrostatic spinning apparatus syringe pump, and the spinneret from the mandrel is received 70 ~ 100mm; then start the process of electrostatic spinning, electrostatic spinning parameters received starting at 100 rpm spindle ...

Embodiment 2

[0085] A method of preparing a barrier membrane for guided bone regeneration, comprising the steps of:

[0086] (1) Preparation of gelatin solution

[0087] a, dissolving liquid configuration:

[0088] Was dissolved in purified water accounting for 38wt%, the proportion of acetic acid 27wt%, butyl acetate accounting for 35wt%;

[0089] B, was dissolved gelatin mass ratio 1: 7 ratio were mixed to dissolve, to obtain complete dissolution of the gelatin solution; the gelatin is a bovine gelatin, gel strength in the range of 190 bloom g;

[0090] (2) Preparation of gelatin fiber membrane

[0091] The prepared solution was added to the gelatin with glutaraldehyde, a crosslinking agent proportion of 0.55 wt%, the solution was injected into the mixed electrostatic spinning apparatus syringe pump, and the spinneret received from the mandrel of 90mm ; then start the process of electrostatic spinning, electrostatic spinning parameters received starting at 150 rpm spindle speed, 14kV positiv...

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Abstract

The invention discloses a method for preparing a barrier membrane for guided bone regeneration, which comprises the following steps: (1) preparation of gelatin solution, (2) preparation of gelatin fiber membrane; (3) drying of gelatin fiber membrane: ( 4) Preparation of polycaprolactone solution; (5) Preparation of polycaprolactone fiber membrane; (6) Drying of polycaprolactone fiber membrane: (7) Lamination of gelatin fiber membrane and polycaprolactone fiber membrane : Pressing according to the form of "gelatin fiber film-polycaprolactone fiber film-gelatin fiber film" to obtain a laminated film with a 3-layer laminated structure. The invention can effectively guide the growth of keratinized gums, shorten the repair time, and be applied to the repair of oral cavity and maxillofacial soft tissues in a wider range.

Description

Technical field [0001] The present invention belongs to the field of biomaterials and tissue engineering technology, particularly relates to a barrier film and method for guiding of bone regeneration. Background technique [0002] GBR (guided bone regeneration) guided bone regeneration, is the use of a barrier film properties, prevents surrounding soft tissue from fibroblasts, osteoblasts so that the face of the proliferation sufficient time, and ultimately achieve tissue regeneration, repair object oriented . It based primarily on the different types of tissue cell migration speed characteristics. The artificial membrane with micropores or autologous periosteum secured between the soft tissue and bone defects to form a biological barrier to prevent migration of fast connective tissue and epithelial cells into the bone defect, thereby creating a dominant growth of bone tissue environment , osteoblasts preferentially into the bone defect area, no competitive growth, while protecti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/22A61L27/18A61L27/50B32B9/00B32B9/04B32B27/02B32B27/12B32B27/36B32B37/10B32B38/18D04H1/30D04H1/4258D04H1/435
CPCA61L27/222A61L27/18A61L27/50B32B5/02B32B5/26B32B37/10B32B38/1808D04H1/4258D04H1/30D04H1/435B32B2250/03B32B2250/20B32B2250/40B32B2262/08B32B2262/0276B32B2535/00A61L2430/02A61L2430/12A61L2400/12C08L89/00C08L67/04
Inventor 张婷婷董佳桓张阳
Owner NEO MODULUS SUZHOU MEDICAL SCI TECH CO LTD
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