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Absorbable oral repair film and preparation method thereof

A technology for oral restoration and composite film, applied in the field of absorbable oral adsorption film and its preparation, can solve the problems of patient pain, narrow application range, long chairside time, etc. The effect of shortening the operation time

Active Publication Date: 2021-06-22
NEO MODULUS SUZHOU MEDICAL SCI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Currently used in the repair of oral tissue defects, autologous tissue transplantation is limited, and it will cause additional pain to the patient, and it also has high requirements for the doctor's technical level, and the chair time is longer
Tissue engineering materials such as ADM (Acellular Dermal Matrix) and CM (Collagen Matrix Membrane) have problems such as relatively narrow application range, complications, long repair time, and unsatisfactory long-term effects.
PRF (platelet-rich fibrin) is not suitable for a large number of materials, and the existing centrifugation methods and equipment also determine that only small-area PRF can be prepared, which is difficult to apply to large-scale defects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A method for preparing an absorbable oral restoration film, comprising a gelatin fiber film preparation process, a polycaprolactone fiber film preparation process, a composite film pressing process, and a post-treatment process,

[0042] Described gelatin fiber membrane preparation process comprises the steps:

[0043] S1.1, preparation of gelatin solution,

[0044] First, the purified water, acetic acid and ethyl acetate were prepared as a dissolving solution, and the purified water accounted for 35wt% in the prepared dissolving solution, the acetic acid accounted for 25wt%, and the ethyl acetate accounted for 40wt%;

[0045] Then, the gelatin and the prepared lysate are prepared as a gelatin solution. In the prepared gelatin solution, the mass ratio of the gelatin to the lysate is 1:8, the gelatin is bovine bone gelatin, and the freezing force range is 160 bloom g;

[0046] Preferably: in step S2.1 of the polycaprolactone fiber film preparation process, the intrinsic...

Embodiment 2

[0065] A method for preparing an absorbable oral restoration film, comprising a gelatin fiber film preparation process, a polycaprolactone fiber film preparation process, a composite film pressing process, and a post-treatment process,

[0066] Described gelatin fiber membrane preparation process comprises the steps:

[0067] S1.1, preparation of gelatin solution,

[0068] First, the purified water, acetic acid and ethyl acetate were prepared as a dissolving solution, and the purified water accounted for 40wt% in the prepared dissolving solution, the acetic acid accounted for 30wt%, and the ethyl acetate accounted for 30wt%;

[0069] Then, the gelatin and the prepared lysate are formulated into a gelatin solution. In the prepared gelatin solution, the mass ratio of the gelatin to the lysate is 1:6, the gelatin is bovine bone gelatin, and the freezing force range is 200 bloom g;

[0070] Preferably: in step S2.1 of the polycaprolactone fiber film preparation process, the intri...

Embodiment 3

[0089] A method for preparing an absorbable oral restoration film, comprising a gelatin fiber film preparation process, a polycaprolactone fiber film preparation process, a composite film pressing process, and a post-treatment process,

[0090] Described gelatin fiber membrane preparation process comprises the steps:

[0091] S1.1, preparation of gelatin solution,

[0092] First, the purified water, acetic acid and ethyl acetate were prepared as a dissolving solution, and the purified water accounted for 38wt% in the prepared dissolving solution, the acetic acid accounted for 28wt%, and the ethyl acetate accounted for 35wt%;

[0093] Then, the gelatin and the prepared lysate are formulated into a gelatin solution, and in the prepared gelatin solution, the mass ratio of the gelatin to the lysate is 1:7, the gelatin is bovine bone gelatin, and the freezing force range is 180 bloom g;

[0094] Preferably: in step S2.1 of the polycaprolactone fiber membrane preparation process, t...

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Abstract

The invention discloses an oral restoration film and a preparation method thereof. The oral restoration film uses gelatin and polycaprolactone as raw materials, respectively obtains a film composed of nano-scale fibers by using an electrospinning process, and uses gelatin layer-polycaprolactone as raw materials. The sequence of ester layer-gelatin layer is pressed to obtain a three-layer oral restoration film with a gradual change in fiber diameter. The preparation method of the dental restoration film comprises the following steps: preparation of gelatin solution, preparation of gelatin film, drying of gelatin film, preparation of polycaprolactone solution, preparation of polycaprolactone film, drying of polycaprolactone film, Lamination, cutting, inner packaging, sterilization and outer packaging of gelatin fiber film and polycaprolactone fiber film. The invention can effectively guide the growth of keratinized gums, shorten the repair time, and be applied to the repair of oral cavity and maxillofacial soft tissues in a wider range.

Description

technical field [0001] The invention belongs to the technical field of biological materials and tissue engineering, and in particular relates to an absorbable oral cavity adsorption film and a preparation method thereof. Background technique [0002] Oral tissue defects need to be repaired. At present, oral tissue defects mainly include loss of periodontal tissue, insufficient or missing width of attached gingiva, defect after maxillofacial tumor resection, wound dehiscence after GBR, and donor site defect of connective tissue transplantation. , maxillary sinus fistula, wound closure after mandibular impacted tooth extraction, gingival recession, root surface exposure, abnormal frenulum attachment position / vestibular groove too shallow, buccal mucosal tissue defect, and prevention of gustatory sweating syndrome, etc. [0003] At present, in the repair of oral tissue defects, autologous tissue transplantation is limited, and it will cause additional pain to the patient. It al...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/22A61L27/58A61L27/18D04H1/30D04H1/435D04H1/728
CPCA61L27/18A61L27/222A61L27/58D04H1/30D04H1/435D04H1/728C08L67/04
Inventor 靳柯张阳
Owner NEO MODULUS SUZHOU MEDICAL SCI TECH CO LTD
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