Medicinal composition for rapidly alleviating pain and eliminating swelling after operation and preparation method thereof

A pharmaceutical composition and rapid technology can be used in pharmaceutical formulations, pharmaceutical combinations, medical preparations containing active ingredients, etc., and can solve the problems of unsatisfactory anti-inflammatory and analgesic effects, differences in effects, and insignificant differences in beauty seekers. Reduced migration and phagocytosis, better efficacy, less gastrointestinal reactions and psychiatric symptoms

Active Publication Date: 2020-06-30
赵军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the clinical observation, it was found that in the early postoperative period, especially within 72 hours after the operation, the anti-inflammatory and analgesic effect of using this product is not ideal, and the pain, swelling and bruises are still obvious, and the difference from those who do not take it is not significant.
The difference in the effect may even appear one week after the operation, which is far below the expectation of the beauty seeker

Method used

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  • Medicinal composition for rapidly alleviating pain and eliminating swelling after operation and preparation method thereof
  • Medicinal composition for rapidly alleviating pain and eliminating swelling after operation and preparation method thereof
  • Medicinal composition for rapidly alleviating pain and eliminating swelling after operation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The invention provides a pharmaceutical composition for rapid postoperative pain relief and detumescence, which consists of non-steroidal anti-inflammatory drug injection, glucocorticoid injection, serotonin receptor antagonist injection, vitamin injection and normal saline composition.

[0038] Among them, non-steroidal anti-inflammatory drug injection: glucocorticoid injection: serotonin receptor antagonist injection: vitamin injection: normal saline = 25~50mg: 2.5~20mg: 2.5~15mg: 0.25~3.0g: 100ml .

[0039] In the present embodiment, the non-steroidal anti-inflammatory drug injection is selected from 100% flurbiprofen axetil injection; the glucocorticoid injection is selected from 100% dexamethasone injection; the serotonin receptor antagonism 100% tropisetron injection is selected for the dosage injection; 100% vitamin C injection is selected for the vitamin injection.

[0040] The flurbiprofen axetil injection used in the present invention is the prodrug of flurb...

Embodiment 2

[0073] As another embodiment of the present invention, another pharmaceutical composition for rapid postoperative pain relief and detumescence consists of the following components: non-steroidal anti-inflammatory drug injection, glucocorticoid injection, hemostatic freeze-dried powder, serotonin receptor antagonist injection, vitamin injection and normal saline. Among them, non-steroidal anti-inflammatory drug injection: glucocorticoid injection: hemostatic freeze-dried powder: serotonin receptor antagonist injection: vitamin injection: normal saline = 25~100mg: 2.5~20mg: 0.5~2KU: 2.5 ~15mg: 0.25~3.0g: 100ml.

[0074] Compared with Example 1, the composition of Example 2 also includes hemostatic freeze-dried powder. Wherein, the hemostatic freeze-dried powder is selected from snake venom hemocoagulase for injection, approved by the Chinese Medicine Standard H20041419, produced by Penglai Nuokang Pharmaceutical Co., Ltd.

[0075] In the operation and early postoperative perio...

experiment example 2

[0134] Experimental composition 3: non-steroidal anti-inflammatory drug injection (flurbiprofen axetil injection): glucocorticoid injection (dexamethasone): 5-HT3 receptor antagonist (tropisetron): normal saline =25mg: 5mg: 5mg: 100ml.

[0135] Experimental composition 4: non-steroidal anti-inflammatory drug injection (flurbiprofen axetil injection): glucocorticoid injection (dexamethasone): 5-HT3 receptor antagonist (tropisetron): normal saline =25mg: 20mg: 15mg: 100ml.

[0136] In addition, 26 female patients with facial plastic surgery were selected, aged 23 to 47 years, without systemic diseases, bleeding and coagulation abnormalities. Randomly divided into two groups: treatment group 3 and treatment group 4. There were 12 cases in the treatment group 3, 14 cases in the treatment group 4, and the experimental data in the pre-clinical experiment case 1 were used in the control group. The treatment group 3 was 23-47 years old, and the treatment group 4 was 24-43 years old...

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PUM

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Abstract

The invention provides a medicinal composition for rapidly alleviating pain and eliminating swelling after an operation and a preparation method thereof. The medicinal composition consists of a non-steroidal anti-inflammatory drug injection, a glucocorticoid injection, a serotonin receptor antagonist injection, a vitamin injection and normal saline, or consists of the non-steroidal anti-inflammatory drug injection, the glucocorticoid injection, hemostatic freeze-dried powder, the serotonin receptor antagonist injection, the vitamin injection and the normal saline. The method for preparing themedicinal composition comprises the steps of: respectively extracting each injection subjected to sterilization processing; and mixing the injections. The prepared medicinal composition can eliminatesevere swelling and alleviating problems of pain, discomfort and the like caused by severe swelling in 72 hours after the operation, and implements rapid rehabilitation after the operation.

Description

technical field [0001] The invention relates to a pharmaceutical composition, which is used for rapid pain relief and detumescence after operation. Background technique [0002] 1 to 7 days after traditional plastic surgery, you are basically in a state of pain, obvious swelling, bruising, and limited mobility, and your daily life is affected to varying degrees, especially after facial plastic surgery. Pain, swelling, and bruising are common in the early post-operative period. Symptoms, pain and swelling promote each other, leading to aggravation of symptoms, significantly affecting the facial appearance of the beauty seeker, and seriously affecting the social image. Most beauty seekers can only be in the state of "retreating and thanking guests". Through clinical research, it can be found that fast recovery and shortened recovery period are the absolute needs of the medical and aesthetic industry, and more than 95% of beauty seekers are very concerned about recovery speed. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/222A61K31/573A61K31/46A61K31/375A61P29/00A61P7/10
CPCA61K45/00A61K31/222A61K31/573A61K31/46A61K31/375A61P29/00A61P7/10A61K2300/00
Inventor 赵军张瑜
Owner 赵军
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