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Iontophoresis method of delivering vitamin C through skin

An iontophoresis and vitamin technology, applied in the field of skin care and/or skin appendage care, can solve the problems of low vitamin C solubility, vitamin C oxidation, loss of function, etc., and achieve the effect of improving delivery efficiency

Pending Publication Date: 2020-07-10
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One problem, however, is the very low solubility of vitamin C in non-aqueous media
Also, if dissolved, vitamin C is easily oxidized and thus loses its function

Method used

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  • Iontophoresis method of delivering vitamin C through skin
  • Iontophoresis method of delivering vitamin C through skin
  • Iontophoresis method of delivering vitamin C through skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0262] Iontophoretic transport experiments were performed to quantify the skin deposition of different formulations of ascorbic acid (vitamin C).

[0263] The kinetics of ascorbic acid prepared in different formulations containing 5% ascorbic acid in a polar solvent mixture and specific ratios of anionic and nonionic polymers, and their in vitro exposure to 0.2 mA / cm were measured during different time points. 2 Cathode active release of (-) iontophoresis.

[0264] The dermal delivery of ascorbic acid from different cosmetic gel formulations containing anionic and neutral polymers developed specifically for iontophoresis (in the absence of ionic preservatives and chelating agents) was studied to evaluate its effect on the activity of The effect of drug release.

[0265] In the following, the active agent is vitamin C (ascorbic acid).

[0266] As a second step, formulations containing different polar solvents (ethylene glycol and ethanol) were evaluated to optimize the delive...

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Abstract

The present invention relates to an iontophoresis method of delivering Vitamin C through the skin. The iontophoresis method comprises applying to the skin of a biological subject a composition comprising one or more of Vitamin C, Vitamin C derivatives, ions of Vitamin C, and ions of Vitamin C derivatives, and at least an anionic or non-ionic polymer; applying simultaneously, successively or sequentially over time a selected current curve from any device and / or support comprising at least one electrode to the skin; and operating different Vitamin C at different speeds to pass through the skin according to a selected current mode, wherein the selected current curve is the continuous direct current, the pulsed current or the combination of both, and the characteristics and the duration of thecontinuous direct current, the pulsed current or the combination of both are sufficient to transdermally deliver Vitamin C to the biological subject.

Description

technical field [0001] The present invention relates to the field of skin care and / or skin appendage care. The term "skin and / or appendages thereof" is intended to mean in particular the skin, mucous membranes, lips, scalp, eyelashes, eyebrows and hair. [0002] A subject of the present invention is a method for the cosmetic treatment of the skin and / or its appendages, comprising at least one step of applying to the skin at least one composition comprising at least vitamin C or a derivative thereof. The methods of the invention are not therapeutic. [0003] The present invention also relates to a topical cosmetic and / or dermatological composition comprising at least vitamin C or a derivative thereof in a physiologically acceptable medium. Background technique [0004] Vitamin C and its various forms (e.g., ascorbic acid, ascorbate salts, L-ascorbic acid, ascorbate esters, 2-oxo-L-threo-hexeno-1,4-lactone-2,3-enediol , R)-3,4-dihydroxy-5-((S)-1,2-dihydroxyethyl)furan-2(5H)...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/32
CPCA61N1/325A61K9/0009A61K31/375A61N1/08A61N1/30
Inventor 珍妮佛·卡萨雷斯德拉加迪洛D·波尔多约戈什瓦·N·卡利亚S·德尔里奥桑乔C·塞尔纳吉梅内斯
Owner LOREAL SA