Absorbable Implantable Devices

An implantable and instrumental technology, applied in the direction of prosthesis, surgery, coating, etc., can solve the problems of prolonging the cycle of iron-based stents, hemolysis, and increasing the risk of thrombus

Active Publication Date: 2021-07-20
BIOTYX MEDICAL (SHENZHEN) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the zinc-containing protective body can delay the time point of starting corrosion of the iron-based support, but it cannot solve the problem of too slow corrosion of the iron-based support in the later stage, and even prolongs the complete corrosion period of the iron-based support to a certain extent
Moreover, the zinc-containing protective body continuously releases zinc ions during the corrosion process. If too much zinc ions enters the blood in a short period of time, it may cause hemolysis and secondary coagulation, thereby increasing the risk of thrombosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] An absorbable iron-based stent, the preparation method of which is as follows: after laser engraving and polishing by evaporation method, the mass is 3.8mg, the wall thickness is 50μm, the inner diameter is 1.45mm, and the nitrogen content is 0.05wt.% 30008 specification Galvanized on the nitrided iron-based substrate, a zinc-containing protective layer covering the outer wall, inner wall and side wall of the iron-based substrate is formed on the iron-based substrate, and the thickness of the part of the zinc-containing protective layer located on the outer wall and inner wall of the iron-based substrate Both are 0.4 μm. Subsequently, a mixed solution of poly(racemic lactic acid) and ethyl acetate was inkjet printed on the zinc-containing protective layer, wherein the weight-average molecular weight of the poly(racemic lactic acid) was 200,000, and the ethyl acetate was volatilized to completely cover the zinc-containing protective layer. corrosion-promoting layer. The...

Embodiment 2

[0077] An absorbable iron-based stent, the preparation method of which is as follows: after laser engraving and polishing, the electroplating method is used to obtain a 30008-gauge infiltration with a mass of 3.8 mg, a wall thickness of 50 μm, an inner diameter of 1.45 mm, and a nitrogen content of 0.1 wt.%. Galvanized on the nitrogen-iron-based substrate, a zinc-containing protective layer covering the outer wall, inner wall and side wall of the iron-based substrate is formed on the iron-based substrate, and the thicknesses of the parts of the zinc-containing protective layer located on the outer wall and the inner wall of the iron-based substrate are respectively 0.8μm and 1.2μm. Subsequently, a mixed solution of polyracemic lactic acid and ethyl acetate is sprayed on the zinc-containing protective layer, wherein the weight average molecular weight of the polyracemic lactic acid is 200,000. When spraying, a mandrel with a diameter of 0.8mm is added in the stent, and the mand...

Embodiment 3

[0080] An absorbable iron-based stent, the preparation method of which is as follows: after laser engraving and polishing by evaporation method, the mass is 3.8mg, the wall thickness is 50μm, the inner diameter is 1.45mm, and the nitrogen content is 0.06wt.% 30008 specification Galvanized on the nitrided iron-based substrate, a zinc-containing protective layer covering the outer wall, inner wall and side wall of the iron-based substrate is formed on the iron-based substrate, and the thickness of the part of the zinc-containing protective layer located on the outer wall and inner wall of the iron-based substrate 2.5 μm and 2 μm, respectively. Subsequently, a mixed solution of polyracemic lactic acid and ethyl acetate is sprayed on the zinc-containing protective layer, wherein the weight average molecular weight of the polyracemic lactic acid is 200,000. When spraying, a mandrel with a diameter of 0.5mm is added in the stent, and the mandrel can prevent part of the mixed solutio...

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Abstract

The invention relates to an absorbable implantable device, which comprises an iron-based substrate and a zinc-containing protective layer and a corrosion-promoting layer arranged on the iron-based substrate. The iron-based substrate has an outer wall and an inner wall, and the zinc-containing protective layer covers the iron-based substrate. The outer wall and inner wall of the substrate, the corrosion-promoting layer covers the zinc-containing protective layer, and the thickness ratio of the part of the zinc-containing protective layer on the outer wall to the part of the corrosion-promoting layer on the outer wall is smaller than that of the zinc-containing protective layer on the inner wall and the corrosion-promoting layer The thickness ratio of the part located on the inner wall. The absorbable implantable device has a low risk of thrombus and can meet the requirements of early support and late rapid corrosion.

Description

technical field [0001] The invention relates to the field of interventional medical devices, in particular to an absorbable implantable device. Background technique [0002] Cardiovascular disease is one of the major diseases threatening human health in the 21st century, and intravascular stent implantation is an effective treatment. At present, the bare metal stents and drug-eluting stents widely used clinically are all inert stents, which will remain in the body for a long time after implantation. Due to the long-term existence of the stent, the stent stimulates the blood vessel wall to cause inflammation, and the dissolution of harmful ions in the stent may cause restenosis and late thrombosis. Even in the best case, without the occurrence of the above complications, the long-term restraint of the metal stent will cause the physiological function of the stent-implanted blood vessel to be different from the normal blood vessel. An ideal vascular stent can provide suffici...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/82A61F2/00A61L31/14A61L31/02A61L31/08A61L31/10A61L31/16
CPCA61F2/82A61F2/00A61L31/148A61L31/022A61L31/088A61L31/10A61L31/08A61L31/14A61L31/16A61F2210/0004A61L2400/18A61L2420/02A61L2420/08C08L67/04A61F2210/0076A61F2250/0067A61F2/0077
Inventor 林文娇边东
Owner BIOTYX MEDICAL (SHENZHEN) CO LTD
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