Penthorum chinense pursh extract microcapsule and preparation method thereof

A technology of extracts and microcapsules of C. chinensis, applied in the direction of microcapsules, capsule delivery, drug combination, etc., can solve problems such as lack, and achieve the effects of avoiding degradation, realizing active transport, and high release rate

Active Publication Date: 2020-07-31
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the utilization methods of C. chinensis are mainly limited to extracts and granules, or the whole herb, leaves, stems, flowers, etc. are taken by brewing in boiling water. There is a lack of C. Herb extract preparation or raw material supply form

Method used

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  • Penthorum chinense pursh extract microcapsule and preparation method thereof
  • Penthorum chinense pursh extract microcapsule and preparation method thereof
  • Penthorum chinense pursh extract microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A kind of extract microcapsules of Herba japonica, the preparation method of which comprises the following steps in sequence:

[0038] (1) Cut the stems of C. chinensis into sections, pass through a 60-mesh sieve, and dry by heat pump at 65°C and 1m / s wind speed for 0.5min. Take 20g of C. chinensis, soak in 800ml boiling water for 3 times, each time for 1h, and filter And combine the supernatant, then concentrate to 15% of the original volume, freeze-dry, then add 75vt% ethanol solution to thaw, then use ethanol solution (50vt%, 70vt%) as mobile phase, carry out macroporous resin purification, collect respectively After the solution was concentrated, it was separated by a SephadexL H-20 Sephadex column, and the mobile phase was ethyl acetate-ethanol solution (1:1, 1:2, v / v), and then the extract was evaporated and concentrated, and then freeze-dried. Freeze-dried powder of Decha Huangcao extract;

[0039] (2) Add the wall material (0.27g gelatin powder, 0.03g RG I pectin...

Embodiment 2

[0042] A kind of extract microcapsules of Herba japonica, the preparation method of which comprises the following steps in sequence:

[0043] (1) Cut the whole grass of C. chinensis into sections, pass through a 60-mesh sieve, and dry it with a heat pump at 65°C and a wind speed of 1m / s for 0.5min. Take 20g of C. chinensis, soak it in 800ml boiling water for 3 times, 1 hour each time, filter and dry Combine the supernatants, then concentrate to 15% of the original volume, freeze-dry, then add 75vt% ethanol solution to thaw, then use ethanol solution (50vt%, 70vt%) as mobile phase, carry out macroporous resin purification, collect liquid respectively After concentration, it was separated by SephadexL H-20 dextran gel column, the mobile phase was ethyl acetate-ethanol solution (1:1, 1:2, v / v), and then the extract was evaporated and concentrated, and then freeze-dried to obtain Freeze-dried powder of Herba Grass Extract;

[0044] (2) Add the wall material (0.27g gelatin powder,...

Embodiment 3

[0047] A kind of extract microcapsules of Herba japonica, the preparation method of which comprises the following steps in sequence:

[0048] (1) Heat-pump dry the leaves of C. chinensis at 65°C and 1m / s wind speed for 0.5min. Take 20g of C. chinensis, soak in 800ml of boiling water for 3 times, 1 hour each time, filter and combine the supernatant, and then concentrate to 15% of the original volume, freeze-dried, then added 75vt% ethanol solution to thaw, then used ethanol solution (50vt%, 70vt%) as the mobile phase, and carried out macroporous resin purification, respectively concentrated the collected liquids and passed through SephadexL H-20 Sephadex column separation, the mobile phase is ethyl acetate-ethanol solution (1:1,1:2, v / v), then the extract is evaporated and concentrated, and then freeze-dried to obtain the lyophilized extract of C. pink;

[0049] (2) Add wall material (0.245g gelatin powder, 0.027gRG I pectin okra polysaccharide powder, 0.03g high methoxyl pect...

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Abstract

The invention provides a penthorum chinense pursh extract microcapsule and a preparation method thereof. The preparation method comprises the following steps of drying penthorum chinense pursh, addingboiling water for soaking, performing filtering, concentrating and freeze-drying, adding an ethanol solution for unfreezing, and performing purifying, concentrating, separating, re-concentrating andfreeze-drying to obtain penthorum chinense pursh extract freeze-dried powder; adding a wall material into distilled water, performing stirring until the wall material is completely expanded and dissolved, and adjusting the pH value to obtain a mixed solution; and dissolving the penthorum chinense pursh extract freeze-dried powder with ethanol, adding the dissolved penthorum chinense pursh extractfreeze-dried powder into the mixed solution, adjusting the pH value, and performing stirring, standing, centrifuging and freeze-drying in sequence to obtain the penthorum chinense pursh extract microcapsule. The invention also discloses the penthorum chinense pursh extract microcapsule prepared by the method. The intestinal targeting controlled release of the penthorum chinense pursh extract is realized, so that gastric irritation is reduced, and the bioavailability is increased; and the problems that in the prior art, a penthorum chinense pursh extract preparation with the intestinal tract targeting controlled release effect and a raw material supply form are lacked are effectively solved.

Description

technical field [0001] The invention belongs to the technical field of microcapsules and its preparation, and in particular relates to a microcapsule of Herba chinensis extract and a preparation method thereof. Background technique [0002] Penthorum chinense Pursh (Penthorum chinense Pursh), whose scientific name is root vegetable, is the dry above-ground part of root vegetable of the genus Penthorum Gronvexl in the family Saxifragaceae. According to the "Sichuan Provincial Standards of Chinese Medicinal Materials", "Dictionary of Traditional Chinese Medicine" and "Sichuan Traditional Chinese Medicine", it has the effects of dehumidification and diuresis, dispelling blood stasis and relieving pain. Crimson yellow grass is an authentic medicinal material in Gulin County, Sichuan. It has always been used as a medicinal and edible plant among the people, and it is called "immortal grass". [0003] Flavonoids are the main functional components in C. chinensis. The results of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/50A61K47/36A61K47/42A61P39/06A61P1/16A61P3/10
CPCA61K9/5036A61K9/5057A61K36/185A61K2236/331A61K2236/39A61K2236/51A61P1/16A61P3/10A61P39/06
Inventor 段飞霞王星月张紫涵兰泽伦
Owner SICHUAN UNIV
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