A kind of extract microcapsule and its preparation method

A technology for extracts and microcapsules of C. japonica, applied in the directions of microcapsules, capsule delivery, drug combination, etc., can solve problems such as shortage, and achieve the effects of avoiding degradation, realizing active transport, and high release rate.

Active Publication Date: 2021-06-15
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the utilization methods of C. chinensis are mainly limited to extracts and granules, or the whole herb, leaves, stems, flowers, etc. are taken by brewing in boiling water. There is a lack of C. Herb extract preparation or raw material supply form

Method used

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  • A kind of extract microcapsule and its preparation method
  • A kind of extract microcapsule and its preparation method
  • A kind of extract microcapsule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A kind of extract microcapsules of Herba japonica, the preparation method of which comprises the following steps in sequence:

[0038] (1) Cut the stems of C. chinensis into sections, pass through a 60-mesh sieve, and dry by heat pump at 65°C and 1m / s wind speed for 0.5min. Take 20g of C. chinensis, soak in 800ml boiling water for 3 times, each time for 1h, and filter And combine the supernatant, then concentrate to 15% of the original volume, freeze-dry, then add 75vt% ethanol solution to thaw, then use ethanol solution (50vt%, 70vt%) as mobile phase, carry out macroporous resin purification, collect respectively After the solution was concentrated, it was separated by a SephadexL H-20 Sephadex column, and the mobile phase was ethyl acetate-ethanol solution (1:1, 1:2, v / v), and then the extract was evaporated and concentrated, and then freeze-dried. Freeze-dried powder of Decha Huangcao extract;

[0039] (2) Add the wall material (0.27g gelatin powder, 0.03g RG I pectin...

Embodiment 2

[0042] A kind of extract microcapsules of Herba japonica, the preparation method of which comprises the following steps in sequence:

[0043] (1) Cut the whole grass of C. chinensis into sections, pass through a 60-mesh sieve, and dry it with a heat pump at 65°C and a wind speed of 1m / s for 0.5min. Take 20g of C. chinensis, soak it in 800ml boiling water for 3 times, 1 hour each time, filter and dry Combine the supernatants, then concentrate to 15% of the original volume, freeze-dry, then add 75vt% ethanol solution to thaw, then use ethanol solution (50vt%, 70vt%) as mobile phase, carry out macroporous resin purification, collect liquid respectively After concentration, it was separated by SephadexL H-20 dextran gel column, the mobile phase was ethyl acetate-ethanol solution (1:1, 1:2, v / v), and then the extract was evaporated and concentrated, and then freeze-dried to obtain Freeze-dried powder of Herba Grass Extract;

[0044] (2) Add the wall material (0.27g gelatin powder,...

Embodiment 3

[0047] A kind of extract microcapsules of Herba japonica, the preparation method of which comprises the following steps in sequence:

[0048] (1) Heat-pump dry the leaves of C. chinensis at 65°C and 1m / s wind speed for 0.5min. Take 20g of C. chinensis, soak in 800ml of boiling water for 3 times, 1 hour each time, filter and combine the supernatant, and then concentrate to 15% of the original volume, freeze-dried, then added 75vt% ethanol solution to thaw, then used ethanol solution (50vt%, 70vt%) as the mobile phase, and carried out macroporous resin purification, respectively concentrated the collected liquids and passed through SephadexL H-20 Sephadex column separation, the mobile phase is ethyl acetate-ethanol solution (1:1,1:2, v / v), then the extract is evaporated and concentrated, and then freeze-dried to obtain the lyophilized extract of C. pink;

[0049] (2) Add wall material (0.245g gelatin powder, 0.027gRG I pectin okra polysaccharide powder, 0.03g high methoxyl pect...

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Abstract

The invention provides a microcapsule of the extract of C. chinensis and a preparation method thereof. The preparation method comprises the following steps: drying C. syringa, adding boiling water to soak and filter, then concentrating, freeze-drying, adding ethanol solution to thaw, purifying, Concentration, separation, re-concentration and freeze-drying, to obtain the freeze-dried powder of the extract of C. dissolve, then add to the mixed solution, adjust the pH, stir, then stand still, centrifuge and freeze-dry successively to obtain the microcapsules of the extract of the yellow grass. The present invention also includes the microcapsules of the extract of C. chinensis prepared by the above method. The invention realizes the intestinal targeted and controlled release of the extract of C. chinensis, reduces gastric irritation, and increases the bioavailability; effectively solves the lack of the extract of C. sativa with intestinal target and controlled release in the prior art Preparations and raw material supply forms and other issues.

Description

technical field [0001] The invention belongs to the technical field of microcapsules and its preparation, and in particular relates to a microcapsule of Herba chinensis extract and a preparation method thereof. Background technique [0002] Penthorum chinense Pursh (Penthorum chinense Pursh), whose scientific name is root vegetable, is the dry above-ground part of root vegetable of the genus Penthorum Gronvexl in the family Saxifragaceae. According to the "Sichuan Provincial Standards of Chinese Medicinal Materials", "Dictionary of Traditional Chinese Medicine" and "Sichuan Traditional Chinese Medicine", it has the effects of dehumidification and diuresis, dispelling blood stasis and relieving pain. Crimson yellow grass is an authentic medicinal material in Gulin County, Sichuan. It has always been used as a medicinal and edible plant among the people, and it is called "immortal grass". [0003] Flavonoids are the main functional components in C. chinensis. The results of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K36/185A61K47/36A61K47/42A61P39/06
CPCA61K9/5036A61K9/5057A61K36/185A61K2236/331A61K2236/39A61K2236/51A61P1/16A61P3/10A61P39/06
Inventor 段飞霞王星月张紫涵兰泽伦
Owner SICHUAN UNIV
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