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Application of hydrogen in preparation of composition for preventing or treating oxidative stress injury of brain

A technology of oxidative stress and composition, applied in the field of aerospace medicine, can solve problems such as unproven protective effects, and achieve the effect of reducing oxidative stress damage in the brain

Inactive Publication Date: 2020-08-04
63919 TROOPS PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the current research, the clinical application of hydrogen is mainly through a gas generator such as the hydrogen generator produced by Shanghai Lumei Medical Technology Co., Ltd., which has been commercialized, to generate a hydrogen-oxygen mixture or to dissolve hydrogen into a liquid such as pure water or normal saline. For example, in 2010, Oharazawa H et al. pressurized hydrogen into normal saline to make eye drops to treat retinal diseases, etc., but the protective effect of hydrogen on oxidative stress and brain function damage caused by aerospace environment has not been confirmed.

Method used

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  • Application of hydrogen in preparation of composition for preventing or treating oxidative stress injury of brain
  • Application of hydrogen in preparation of composition for preventing or treating oxidative stress injury of brain
  • Application of hydrogen in preparation of composition for preventing or treating oxidative stress injury of brain

Examples

Experimental program
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Effect test

Embodiment 1

[0017] 1. The effect of hydrogen molecules on the body weight of rats caused by simulated weightlessness.

[0018] 1.1 Animals and experimental drugs

[0019] Select healthy male SD rats, 4-6 weeks old, with an average body weight of 180-200g; in an environment with a temperature of 22°C-26°C and an air humidity of 45%-65%, the natural light is supplemented by artificial light in a breeding room. Raised in cages, animals had free access to food and water; adaptive feeding for one week. The experimental hydrogen (effective concentration is 4.5%) is prepared by mixing 66% hydrogen with air from a hydrogen atomizer of Shanghai Lumei Medical Technology Co., Ltd.

[0020] 1.2 Modeling and grouping

[0021] 1.2.1 Establishment of rat tail suspension simulated weightlessness model

[0022] Use 2 pieces of medical tape to paste on both sides of the tail of the rat, leaving a little distance at the end, about 0.5cm; then use 2 pieces of medical tape to fix it horizontally, and fix i...

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PUM

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Abstract

The invention discloses application of hydrogen in preparation of a composition for preventing or treating oxidative stress injury of a brain. The oxidative stress injury of the brain is caused by anaerospace environment. The beneficial effects of the application are as follows: the invention provides application of the hydrogen in preparation of a composition for preventing or treating oxidativestress injury of the brain in a special aerospace environment. Simulation experiments show that hydrogen can reduce rat brain oxidative stress injury caused by simulated weightlessness, that is, it shows that hydrogen can effectively resist brain oxidative stress injury caused by aerospace and other special environments.

Description

technical field [0001] The invention relates to the technical field of aerospace medicine, in particular to the application of hydrogen in the preparation of a composition for preventing or treating oxidative stress damage in the brain. Background technique [0002] The in-depth development of manned spaceflight requires that astronauts must have the ability to stay in orbit continuously for a long time. Effective medical protection and countermeasures against space environmental factors, and minimizing the impact of the space environment on people are important aspects of space medicine. Task. During spaceflight, astronauts are affected by various physical and chemical factors, which make astronauts in a state of high stress for a long time, causing a series of pathophysiological changes. Especially under long-term microgravity conditions, the level of oxidative stress in the body increases significantly. Oxidative stress in the aerospace environment has gradually become a...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61P25/00A23L33/00
CPCA61K33/00A61P25/00A23L33/00A23V2002/00A23V2200/322A23V2250/12
Inventor 李英贤马雪梅靳小艳
Owner 63919 TROOPS PLA
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