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Broad-spectrum antimicrobial mesoporous silica Schiff base silver complex nanomaterial and preparation method thereof

A mesoporous silica, anti-microbial technology, applied in botanical equipment and methods, chemicals for biological control, medical preparations with inactive ingredients, etc. It can prevent the production of drug-resistant strains, the preparation method is green, and the killing effect is obvious.

Active Publication Date: 2020-12-29
NANJING MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] As far as the inventors know, the existing antibacterial materials are relatively complicated in synthesis process, which requires a lot of manpower, material and financial resources, which makes the cost high and is not conducive to market promotion.
At the same time, the bactericidal effect of existing antibacterial materials is limited, and often only has a killing effect on certain bacteria; the duration of sterilization is short, and it is difficult to continue to sterilize for a long time; after a large number of uses, drug-resistant strains are easy to produce, which will threaten human health.
In addition, some silver-based antibacterial materials are harmful to organisms because of their high silver content, so they cannot directly act on animals or humans.

Method used

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  • Broad-spectrum antimicrobial mesoporous silica Schiff base silver complex nanomaterial and preparation method thereof
  • Broad-spectrum antimicrobial mesoporous silica Schiff base silver complex nanomaterial and preparation method thereof
  • Broad-spectrum antimicrobial mesoporous silica Schiff base silver complex nanomaterial and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049]This example is to prepare mesoporous silica SBA-15.

[0050] The basic preparation process of this embodiment includes:

[0051] S1. Add P123 to deionized water, stir until clear; add hydrochloric acid solution and mix well; add ethyl orthosilicate and stir to react.

[0052] S2. Move the obtained mixture to a high-temperature reactor for reaction, then age in an oven, wash and dry the obtained solid.

[0053] S3. Grinding the solid into powder and calcining to obtain SBA-15.

[0054] The following is the specific preparation process as an example:

[0055] Weigh 4.0 g of P123 into a three-necked flask, add 80 ml of deionized water, and stir until clear at room temperature; add 70 ml of 3.4M HCl to the above clear solution, and stir at 40°C for 1 hour; 9.14 ml tetraethyl orthosilicate was added dropwise, and the constant temperature stirring was continued at 40°C for 24 hours; the above reaction solution was transferred to a high-temperature reactor to continue the r...

Embodiment 2

[0057] This example is for the preparation of aldylated mesoporous silica.

[0058] The basic preparation process of this embodiment includes:

[0059] The first step is to disperse the mesoporous silica obtained in Example 1 in toluene, add 3-aminopropyltriethoxysilane, and react under the reaction conditions; after the reaction, centrifuge and collect the solid; wash the solid, After drying, aminated mesoporous silica is obtained. denoted as NH 2 -SBA-15.

[0060] Among them, the mass volume ratio of mesoporous silica to toluene is 0.6±0.01g:80±5ml; the volume ratio of 3-aminopropyltriethoxysilane to toluene is 0.0025±0.001:1. When adding 3-aminopropyltriethoxysilane, add it dropwise; the specific reaction conditions are: reaction temperature 70°C±5°C, reaction time at least 12 hours, continuous stirring during the reaction; centrifugation conditions: centrifugal speed 5000±500rpm , the centrifugation time is at least 5 minutes; the washing conditions are: wash with etha...

Embodiment 3

[0067] This example is to prepare ε-polylysine modified mesoporous silica and ε-polylysine modified mesoporous silica loaded with silver nanoparticles.

[0068] The basic preparation process of this embodiment is as follows:

[0069] (1) Preparation of ε-polylysine modified mesoporous silica:

[0070] Disperse ε-polylysine in absolute ethanol to form a mixed solution, adjust the pH of the mixed solution with potassium hydroxide to be weakly alkaline, pH=8.0±0.5; add the formylated mesoporous silica obtained in Example 2 , react under reaction conditions; after the reaction, centrifuge and collect the solid; wash and dry the solid to obtain ε-polylysine modified mesoporous silica. Denoted as CHO-SBA-15 / ε-PL.

[0071] (2) Preparation of ε-polylysine-modified mesoporous silica loaded with silver nanoparticles:

[0072] Disperse ε-polylysine in absolute ethanol to form a mixed solution, adjust the pH of the mixed solution with potassium hydroxide to be weakly alkaline, pH=8.0±0...

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Abstract

The invention relates to a broad-spectrum antimicrobial mesoporous silicon oxide Schiff base silver complex nanomaterial and a preparation method thereof. The preparation method comprises: preparing aminated mesoporous silicon oxide, preparing aldylated mesoporous silicon oxide, and preparing a finished product of mesoporous silicon oxide Schiff base silver complex nanometer material. The nanomaterial has a killing effect on a variety of bacteria and fungi, can achieve broad-spectrum, high-efficiency, and continuous sterilization effects, and can prevent the generation of drug-resistant strains while antibacterial.

Description

technical field [0001] The invention relates to a broad-spectrum antimicrobial mesoporous silicon oxide Schiff base silver complex nanomaterial and a preparation method of the nanomaterial, belonging to the technical field of antimicrobial materials. Background technique [0002] As far as the inventors know, the existing antibacterial materials are relatively complex in synthesis process, which requires a lot of manpower, material and financial resources, which makes the cost high and is not conducive to market promotion. At the same time, the bactericidal effect of existing antibacterial materials is limited, and often only kills certain bacteria; the duration of sterilization is short, and it is difficult to continue to sterilize for a long time; after extensive use, drug-resistant strains are prone to occur, which will threaten human health. In addition, some silver-based antibacterial materials are harmful to organisms due to their high silver content, and cannot direct...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00C08K3/08A01N25/08A01N59/16A01P1/00A01P3/00A61K33/38A61K47/02A61K47/34A61P31/04A61P31/06A61P31/10
CPCA01N25/08A01N59/16A61K33/38A61K47/02A61K47/34A61P31/04A61P31/06A61P31/10C08G83/001C08K3/08C08K2003/0806C08K2201/011Y02A50/30
Inventor 陈进毕洪凯蔡铃黄衍强王建明刘巧
Owner NANJING MEDICAL UNIV
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