Application of fluvastatin sodium in preparation of drugs for treating corona virus disease 2019

A technology of fluvastatin sodium and medicine, applied in the field of application in the preparation of drugs for the treatment of new coronary pneumonia

Inactive Publication Date: 2020-09-04
李成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But more data need to carry out more clinical trials to confirm

Method used

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Embodiment Construction

[0014] The present invention is described further in conjunction with embodiment.

[0015] It was observed experimentally that the new coronavirus enters cells through endocytosis only when the culture is rich in GM1 lipid rafts. Cells loaded with cholesterol from serum using the cholesterol transport protein apoE can enhance endocytosis of pseudo-coronavirus. Super-resolution imaging revealed that viral entry was significantly increased in the cholesterol-loaded state (forming GM1 lipid rafts) but significantly decreased in the unloaded state. After the cholesterol-removing chemical methyl-β-cyclodextrin (MβCD) was added to the cells, the virus entry into the cells was inhibited after cholesterol unloading was repeatedly shown. Compared with low cholesterol, high cholesterol (apoE+ serum) virus infection rate is more than 3 times higher; consumption of cellular cholesterol with MβCD almost blocks the entry of all viruses, and the entry of viruses into cells is blocked. Chol...

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Abstract

The invention discloses an application of fluvastatin sodium in the preparation of drugs for treating corona virus disease 2019. The mechanism by which fluvastatin sodium can alleviate corona virus disease 2019 is to weaken the ability of COVID-19 virus to invade human cells through ACE2, thereby inhibiting replication of COVID-19 virus.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to the application of fluvastatin sodium in the preparation of drugs for treating new coronary pneumonia. Background technique [0002] The new crown pneumonia has not been completely eradicated. A few months later, the temperature in autumn and winter will drop and the body's immune system will be weakened. Not only will it be susceptible to influenza and common pneumonia, but it will also be susceptible to new coronary pneumonia. If you refer to the 1918 spring flu, the number of patients and deaths caused by the second wave of autumn flu far exceeds that of the first wave. Therefore, the pressure of epidemic prevention and control in autumn and winter this year is very high. Our vaccine is progressing well, but there is still a third phase of clinical trials to be done. Considering the production capacity, it is difficult to say whether the time will be enough. The efficacy of the vaccine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/405A61P11/00A61P31/14
CPCA61K31/405A61P11/00A61P31/14
Inventor 李成
Owner 李成
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