A product for preventing and/or treating atopic dermatitis

A technology for atopic dermatitis and products, applied in the field of microorganisms, can solve problems such as adverse reactions, poor tolerance of patients, and life troubles of patients, and achieve the effect of reducing the number of scratches, improving skin pathological symptoms, and improving behavioral characteristics

Active Publication Date: 2022-08-09
JIANGNAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the above-mentioned drugs have relatively large adverse reactions, and most patients have concerns about hormone drugs, which not only bring great difficulties to the treatment of atopic dermatitis, but also bring great difficulties to the lives of patients. In addition, these drugs are poorly tolerated by individual patients

Method used

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  • A product for preventing and/or treating atopic dermatitis
  • A product for preventing and/or treating atopic dermatitis
  • A product for preventing and/or treating atopic dermatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1: Effects of different Lactobacillus casei on scratching times in mice with atopic dermatitis

[0056] Thirty-six 6-week-old SPF (specific pathogen free) C57BL / 6 female mice were randomly divided into 6 groups with 6 mice in each group. The 6 groups were: blank group, model group, positive reference group and three groups of cheese milk Lactobacillus experimental group, among which, the positive reference group is L.GG group by gavage of Lactobacillus rhamnosus GG, the three groups of L. The CA1 group and the CA2 group that received Lactobacillus casei 2 by gavage. All mice were housed within an SPF barrier with free access to food and water.

[0057] The experiment consisted of four weeks: the first week was the adaptation period of the mice; the second week started the gavage until the end of the experiment, the positive control group and the three Lactobacillus casei experimental groups were respectively gavaged with Lactobacillus rhamnosus GG, Lactobacillu...

Embodiment 2

[0060] Example 2: Effects of different Lactobacillus casei on behavioral indexes of mice with atopic dermatitis

[0061] Thirty-six 6-week-old SPF (specific pathogen free) C57BL / 6 female mice were randomly divided into 6 groups with 6 mice in each group. The 6 groups were: blank group, model group, positive reference group and three groups of cheese milk Lactobacillus experimental group, among which, the positive reference group is L.GG group by gavage of Lactobacillus rhamnosus GG, the three groups of L. The CA1 group and the CA2 group that received Lactobacillus casei 2 by gavage. All mice were housed within an SPF barrier with free access to food and water.

[0062] The experiment consisted of four weeks: the first week was the adaptation period of the mice; the second week started the gavage until the end of the experiment, the positive control group and the three Lactobacillus casei experimental groups were respectively gavaged with Lactobacillus rhamnosus GG, Lactobacil...

Embodiment 3

[0065] Example 3: Effects of different Lactobacillus casei on ear thickness of mice with atopic dermatitis

[0066] Thirty-six 6-week-old SPF (specific pathogen free) C57BL / 6 female mice were randomly divided into 6 groups with 6 mice in each group. The 6 groups were: blank group, model group, positive reference group and three groups of cheese milk Lactobacillus experimental group, among which, the positive reference group is L.GG group by gavage of Lactobacillus rhamnosus GG, the three groups of L. The CA1 group and the CA2 group that received Lactobacillus casei 2 by gavage. All mice were housed within an SPF barrier with free access to food and water.

[0067] The experiment consisted of four weeks: the first week was the adaptation period of the mice; the second week started the gavage until the end of the experiment, the positive control group and the three Lactobacillus casei experimental groups were respectively gavaged with Lactobacillus rhamnosus GG, Lactobacillus c...

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Abstract

The present invention relates to a product for preventing and / or treating atopic dermatitis, belonging to the technical field of microorganisms and the technical field of medicine. The present invention provides a product for preventing and / or treating atopic dermatitis. The product contains Lactobacillus casei with a deposit number of GDMCC No.60736, and the Lactobacillus casei can relieve atopic dermatitis, which is embodied in: Significantly reduced scratching times in mice with atopic dermatitis; significantly improved the behavioral characteristics of mice with atopic dermatitis; significantly improved ear swelling in mice with atopic dermatitis; significantly improved skin pathological symptoms in mice with atopic dermatitis; Significantly reduces the serum IgE level of atopic dermatitis mice; significantly reduces the serum IL-4 level of atopic dermatitis mice, and at the same time, increases the serum IL-10 level of atopic dermatitis mice, thereby restoring atopic Balanced Th1 / Th2 immune responses in dermatitis mice.

Description

technical field [0001] The present invention relates to a product for preventing and / or treating atopic dermatitis, belonging to the technical field of microorganisms and the technical field of medicine. Background technique [0002] Atopic dermatitis (AD) is a common clinical chronic, recurrent and inflammatory skin disease. The prevalence of atopic dermatitis is on the rise worldwide, and in recent years, atopic dermatitis affects nearly 1 / 3 of children and 3% of adults worldwide. Atopic dermatitis can cause recurrent skin itching symptoms, which greatly affects the work and life of patients, and greatly reduces the quality of life of patients. [0003] With the in-depth study of genetics and immunology, the occurrence of atopic dermatitis is related to the combined influence of genetic factors and environmental factors. Among them, the "hygiene hypothesis" is based on the influence of environmental factors on the immune development and regulation of patients. It claims ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/747A61P17/00A23C9/123A23C11/10A23C20/02A23L2/38A23L33/00C12R1/245
CPCA61K35/747A61P17/00C12N1/20A23C9/123A23C11/106A23C20/025A23L33/00A23L2/382A23V2400/125Y02A50/30
Inventor 王顺余付成丽何建新郑宋友李国平崔树茂陆文伟赵建新张灏陈卫
Owner JIANGNAN UNIV
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