Hydrogel material used for treating full-thickness burn wound surface and preparation method of hydrogel material

A hydrogel and wound surface technology, applied in medical science, bandages, etc., can solve problems such as failure to achieve hydrogel, inability to resist bacterial invasion, increase risk of infection, etc., and achieve good postoperative cleaning convenience and good self-healing Performance, the effect of excellent biocompatibility

Inactive Publication Date: 2020-09-29
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, after the hydrogel is placed on the wound, the movement of body muscles can easily lead to damage or even rupture of the colloid, which increases the risk of infection, and also destroys the structure of the hydrogel and affects its function.
In addition, the hydrogel itself is not antibacterial and cannot resist the invasion of bacteria, so there is a risk of infection
After long-term use of hydrogel, the hydrogel swells due to its strong water absorption capacity, and it is poorly attached to the wound surface
In addition, the ideal hydrogel applied to burn wounds needs to meet higher requirements: self-repairing dressing damage, with strain resistance; carrying some drugs to prevent wound infection, with antibacterial properties; state can be changed, with long-term fit ; Release some kind of drug that promotes wound healing; however, there is no hydrogel that can achieve the above characteristics in clinical practice

Method used

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  • Hydrogel material used for treating full-thickness burn wound surface and preparation method of hydrogel material
  • Hydrogel material used for treating full-thickness burn wound surface and preparation method of hydrogel material
  • Hydrogel material used for treating full-thickness burn wound surface and preparation method of hydrogel material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A hydrogel material for treating full-thickness burn wounds is an ABA type triblock network copolymer formed by polymerizing polyethylene glycol monomers and N-isopropylacrylamide monomers. The compound comprises a mussel biomimetic tissue bonding group and a silver nanoparticle anchoring group, the hydrogel is loaded with silver nanoparticle, and the surface and interior of the hydrogel are loaded with cyclosporin A. Wherein the ABA type triblock network copolymer structural formula is as follows:

[0033]

[0034] It has temperature-sensitive properties (such as figure 1 ), which is in a liquid state at room temperature or below body temperature, and turns into a gel state at body temperature or when it contacts the body surface, which is convenient for its storage and transportation, and is beneficial for surgical use such as spraying or injection.

[0035] The preparation method of the hydrogel refers to the method in "ACS applied materials&interfaces. 2017; 9(1...

experiment example 1

[0041] Construct rat severe burn model, the hydrogel material obtained in embodiment 1 (with the mass ratio of polyethylene glycol monomer and N-isopropylacrylamide monomer 1:3, the number average molecular weight of polyethylene glycol is 8000 as an example) is used for repairing after burns, and discusses the protective effect of the hydrogel material obtained in Example 1 for the recovery of local tissues of rats after burns and the inhibition of systemic inflammatory response. The method is as follows:

[0042] Take 40 rats and divide them into 4 groups, control group (Control), model group (Burn), positive control group (Burn+Intrasite Gel), and experimental group (Burn+HydrogelA). All rats were shaved on the back, and carried out general anesthesia with 1% pentobarbital sodium 1mL intraperitoneal injection, taking the area as 30% of the total surface area (TBSA=K*W*0.5, K=0.9, W is the weight of the mouse) as burn area. All rats except the control group were anesthetize...

experiment example 2

[0049] The hydrogel prepared in "ACS applied materials&interfaces.2017; 9(11):9221-9225" was used in the severe burn model of rats mentioned above, which was recorded as the positive control group 2. By loading CsA, it was compared with the experimental group of the present invention. The results are shown in Table 2:

[0050] Table 2

[0051]

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PUM

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Abstract

The invention provides a hydrogel material used for treating a full-thickness burn wound surface. The hydrogel material is an ABA type triblock reticular copolymer formed by polymerization of polyethylene glycol monomers and N-isopropylacrylamide monomers, a mass ratio of the polyethylene glycol monomers to the N-isopropylacrylamide monomers is 1:(3-4), the copolymer contains mussel bionic tissuebonding groups and silver nanoparticle anchoring groups, hydrogel is loaded with silver nanoparticles, and cyclosporin A is loaded to the surface and the inside of the hydrogel. The prepared hydrogelmaterial has the characteristics of high adaptability, biocompatibility, adhesiveness, heat sensitivity, injectability and antimicrobial property, and particularly, the hydrogel material can efficiently promote the healing speed of the full-thickness burn wound surface.

Description

technical field [0001] The invention belongs to the technical field of hydrogel materials, and in particular relates to a hydrogel material for treating full-thickness burn wounds and a preparation method thereof. Background technique [0002] Burn is a kind of tissue damage caused by various heat sources including hot liquid, high-temperature gas, flame, red-hot metal, chemical substances, etc., and mainly occurs in surface tissues such as skin and mucous membranes. After severe burns, in addition to regional local skin and mucous membrane damage, the following reactions may also occur: increased metabolism, decreased body temperature, excessive water loss, massive loss of protein, and disorders of the endocrine and immune systems. The exposed burn wounds, in addition to causing the body's fluid balance disorder and the destruction of the defense barrier in a short period of time, the wounds that do not heal for a long time will also become a breeding ground for bacterial c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0019A61L26/0061A61L26/0066A61L26/008A61L2300/104A61L2300/252A61L2300/404C08L87/005
Inventor 毕思伟何谦许飞
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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