Cleaning sterilization process and cleaning sterilization equipment

Abstract

The invention provides a cleaning sterilization process and cleaning sterilization equipment, and relates to the technical field of medical collagen solution production. The cleaning and sterilizationprocess, and the cleaning and sterilization equipment are used in a sterilization filtering system. The cleaning sterilization process includes the steps that a sterilization step is carried out, specifically, before a filtering operation is performed, close a communicating position of a communication path and a preparation device is closed, and steam sterilization is carried out on the communication path and a filter system; a cleaning step includes a second acid cleaning step or a lye cleaning step and a second water cleaning step which are sequentially executed after the filtering operation, wherein the second acid cleaning step or the lye cleaning step includes using acid or lye to clean a containing device, the communication path and the filtering system; and the second water cleaning step includes using water for injection to clean the containing device, the communicating path and the filtering system. The cleaning sterilization process ensures the cleanliness of the equipment and the sterility of a filtrate obtained during the continuous filtering operation through steam sterilization, acid washing or alkali washing and water washing.

Description

technical field [0001] The application relates to the technical field of medical collagen solution production, in particular to a cleaning and sterilization process and cleaning and sterilization equipment. Background technique [0002] Due to the instability of the solution, the medical collagen solution cannot be sterilized by final sterilization methods including heat sterilization and gas sterilization, and the sterilization process needs to be sterilized by filtration. Medical collagen solutions often have certain requirements on the concentration, and high concentrations directly lead to high viscosity of the collagen solution, which brings great difficulties to the process of filtration and sterilization. [0003] Therefore, after filtering the highly viscous collagen solution, collagen will inevitably adhere to the equipment and pipelines. Collagen remains in the equipment and pipelines, which increases the risk of equipment and pipelines being blocked, increases th...

AI Technical Summary

Problems solved by technology

Collagen remains in equipment and pipelines, which increases the risk of equipment and pipelines being blocked, increases the difficulty of filtration operations, and makes it difficult to ensure the sterility of the filtrate

At the same time, collagen degrades and continuously releases impurities during the filtration process, which makes the purity of collagen decrease and impurities increase, and continues to cause pollution during the filtration process

[0004] In this regard, the cleaning equipment and processes used in the prior art are difficult to deal with the above series of problems caused by collagen residues

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