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pgs/sf electrospun membrane and preparation method thereof

An electrospinning membrane and electrospinning technology, applied in the field of PGS/SF electrospun membrane and its preparation, can solve the problem of unknown performance, and achieve the effects of good mechanical strength, improved biological activity and low modulus

Active Publication Date: 2022-03-01
VIOLET HOME TEXTILE TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether the above-mentioned micro-nano-scale oriented fibers have good film-forming properties, and the performance after film formation is still unknown, and when used in vivo, because the internal environment is a water environment, PEO will dissolve in water, resulting in the dissolution or degradation of the fibers

Method used

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  • pgs/sf electrospun membrane and preparation method thereof
  • pgs/sf electrospun membrane and preparation method thereof
  • pgs/sf electrospun membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Synthesis of PGS prepolymer: Take 0.1mol of sebacic acid and 0.1mol of glycerin into a 250mL three-necked flask, place it on a magnetic stirrer to stir and heat the reaction, feed nitrogen at room temperature, heat in an oil bath, and stir at 125°C After heating for 4 hours, the monomers were completely melted and mixed uniformly. The reaction was continued for 48 h while maintaining the temperature under a nitrogen atmosphere to obtain a PGS prepolymer. Cooled to room temperature to white waxy solid, stored at 4-8°C for later use.

[0045] The synthetic route of PGS is as follows, wherein n=6-50:

[0046]

[0047] (2) Preparation of SF membrane: Weigh 21.2g of anhydrous sodium carbonate and dissolve it in 10L of deionized water that has been heated and boiled, then degumming 25g of silkworm silkworm silk at 100°C for 30min, and take it out with deionized water after degumming is complete Repeat washing five times to remove residual sericin. After the filament...

Embodiment 2

[0052] Prepare PGS / SF electrospun membrane according to the method of Example 1, the difference is that in step (3), the concentration of spinning solution is 9%, and the mass ratio of PGS and SF is 70 / 30, 50 / 50, 30 / 70, 0 / 100, the electrospinning parameters are the same as in Example 1. When the dissolved PGS content exceeds 70%, the concentration of the spinning solution is low and it is difficult to form by electrospinning, so the highest PGS content is selected to be 70%.

[0053] The SEM images of PGS / SF electrospun membranes with different mass ratios at the same concentration figure 2 shown. The PGS / SF electrospun materials of various mass ratios were composed of randomly distributed fibers, and the fiber diameter of the pure SF electrospun membrane was the largest, with an average diameter of 1.998 μm ( figure 2 In d1, d2), when the PGS / SF ratio is 70 / 30, the average fiber diameter is 0.597μm ( figure 2 a1, a2), when the PGS / SF ratio is 50 / 50, the fiber diameter ...

Embodiment 3

[0055] In order to investigate the influence of solidification time on the PGS / SF electrospun membrane, the PGS / SF electrospun membrane was prepared according to the method of Example 1, the difference being that in step (3), the concentration of the spinning solution was 9%, PGS and The mass ratio of SF was 50 / 50; in step (4), the electrospun membrane was dried and cured in a vacuum oven at 120°C for 6h, 12h, 18h, and 24h, respectively.

[0056] like image 3 as shown, image 3 The a-d in the figure are the SEM test pictures of the PGS / SF electrospun membranes dried and cured for 6h, 12h, 18h, and 24h at 120°C, respectively. With the prolongation of curing time, PGS melted, and some fibers appeared in the electrospun membrane. After curing for 24 hours, the phenomenon of PGS melting was obvious, but the fiber morphology was clear.

[0057] The FTIR-ATR spectra of PGS / SF electrospun membranes with different curing times are as follows: Figure 4 shown. When the curing time...

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Abstract

The invention relates to a PGS / SF electrospun membrane and a preparation method thereof. The preparation method of the PGS / SF electrospinning film of the present invention comprises the following steps: dissolving the PGS prepolymer and dry SF in an organic solvent to obtain a spinning solution, performing electrospinning on the spinning solution, and adopting a planar receiving The device receives micro-nano-scale fibers, which are dried and solidified after spinning to obtain PGS / SF electrospun membrane; the mass ratio of PGS prepolymer to SF is 0.1-100:0.1-100. The invention uses SF to improve the spinnability and fibrillation of PGS, and successfully obtains PGS / SF electrospun membrane. The electrospun membrane has both the excellent elasticity of PGS and the excellent biological and mechanical properties of SF. The electrospun membrane is cured After that, it still has a good micro-nano fiber structure, good mechanical strength in dry and wet state, and low modulus in wet state.

Description

technical field [0001] The invention relates to an electrospun membrane, in particular to a PGS / SF electrospun membrane and a preparation method thereof. Background technique [0002] Bioelastomers can be used for diagnosis, repair or replacement of body soft tissues because of their modulus matching most of the soft tissue organs of the human body. [0003] Polyglyceryl sebacate (PGS) is a biodegradable nonlinear three-dimensional network thermosetting polyester elastomer, which is easy to synthesize, elastic, biocompatible and biodegradable, and is a typical bioelastomer. Based on the good performance of PGS, it is mainly used in soft tissue replacement and soft tissue engineering, such as myocardium, blood vessels, nerves, cartilage, retina, and tympanic membrane. It is also used in the research of drug delivery carriers and tissue adhesion materials. Silk fibroin (SF) is a natural high-molecular fiber protein extracted from silk. It is rich in sources, has good biocompa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/728D04H1/4382
CPCD04H1/728D04H1/4382
Inventor 赵荟菁张迎梅陈凤袁燕汪明星刘金抗
Owner VIOLET HOME TEXTILE TECH
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