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A feature extraction method for posterior cingulate functional connectivity associated with cognitive impairment in patients with type 2 diabetes mellitus

A technology for type 2 diabetes, cognitive impairment, applied in the field of medicine

Active Publication Date: 2022-05-06
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Because the posterior cingulate cortex plays an important functional role in cognitive impairment, previous studies rarely use the posterior cingulate cortex as a seed ROI to determine its relationship with the whole brain regions of cognitive impairment patients in the type 2 diabetes group. Related functional connectivity

Method used

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  • A feature extraction method for posterior cingulate functional connectivity associated with cognitive impairment in patients with type 2 diabetes mellitus
  • A feature extraction method for posterior cingulate functional connectivity associated with cognitive impairment in patients with type 2 diabetes mellitus
  • A feature extraction method for posterior cingulate functional connectivity associated with cognitive impairment in patients with type 2 diabetes mellitus

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Embodiment Construction

[0022] Materials and Methods

[0023] Sample personnel

[0024] We recruited 48 sample persons (24 patients with cognitive impairment in the type 2 diabetes group and 24 healthy controls). Informed consent was obtained from each sample person. According to the latest standard published by the American Diabetes Association: HbA 1c ≥6.5% (48mmol / mol); fasting blood glucose ≥7.0mmol / L (126mg / dL); oral glucose tolerance test (OGTT) 2h postprandial blood glucose ≥1.1mmol / L (200mg / dL); hyperglycemia or risk of hyperglycemia Symptoms and random blood sugar ≥ 11.1mmol / L (200mg / dL), no symptoms of hyperglycemia, review 1 to 3 criteria, the control group and type 2 diabetes patients with cognitive impairment were matched in terms of age, gender and education, MOCA score greater than or equal to 26. Sample persons were excluded if they had a history of psychiatric illness, stroke, epilepsy, head trauma, brain surgery, cerebrovascular accident, or evidence of impaired cognitive functi...

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Abstract

The invention discloses a feature extraction method of posterior cingulate gyrus functional connectivity related to patients with type 2 diabetes mellitus cognitive impairment. Evaluation of small vessel disease, functional data analysis, statistical analysis, head movement analysis, functional connectivity analysis and correlation analysis, the present invention more accurately verifies the weak functional connectivity of the posterior cingulate cortex to multiple brain regions and type 2 These functional connectivity pathways in the posterior cingulate cortex may serve as biomarkers to further reveal the biological mechanisms underlying the neuropathological process of type 2 diabetes-associated cognitive impairment, and May provide evidence for further molecular biology research.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a feature extraction method of posterior cingulate functional connectivity related to type 2 diabetic cognitive impairment patients. Background technique [0002] The posterior cingulate cortex (PCC) is considered the cortical hub of the default mode network (DMN). The goals of our current study were to determine whether functional connectivity (FC) is altered in the posterior cingulate cortex and whole brain regions in patients with type 2 diabetes mellitus (T2DM) and to determine their relationship to cognitive impairment. This study characterized the functional connectivity of the posterior cingulate cortex in 24 patients with cognitive impairment in the type 2 diabetic patient group and 24 well-matched healthy controls using resting-state functional MRI and a seed-based whole-brain correlation approach Compare. Spearman's correlation analysis was used to determine the relationship b...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B20/00G16B40/00G16B50/00
CPCG16B20/00G16B40/00G16B50/00
Inventor 邱士军谭欣覃春红冷西陈羽娜郑燕婷梁馨予刘玉洁李伊凡杨锦泉
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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