Application of CICs in breast tumor tissues in preparation of product for predicting breast cancer prognosis survival

A technology of breast cancer and tissue, applied in the field of application of CICs in breast tumor tissue in the preparation of products for predicting breast cancer prognosis and survival, can solve the problems of limited value of breast cancer prognosis predictors, and achieve significant originality and accurate subtype analysis Effect

Active Publication Date: 2020-10-02
BEIJING SHIJITAN HOSPITAL CAPITAL MEDICAL UNIVERSTY +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In conclusion, currently routinely used clinical prognostic indicators for breast cancer have limited value

Method used

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  • Application of CICs in breast tumor tissues in preparation of product for predicting breast cancer prognosis survival
  • Application of CICs in breast tumor tissues in preparation of product for predicting breast cancer prognosis survival
  • Application of CICs in breast tumor tissues in preparation of product for predicting breast cancer prognosis survival

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1. Establishment of a method for predicting the prognosis of breast cancer by CICs subtypes in tumor tissue

[0062] 1. Pretreatment of breast tumor tissue sections for dewaxing and antigen retrieval

[0063] 1. Obtain paraffin pathological sections with breast tumor tissue;

[0064] 2. Bake the paraffin sections at 65°C for 1.5 hours;

[0065] 3. Dewaxing by xylene Ⅰ and Ⅱ for 5-10 minutes each, then put in 100%, 95%, 90%, 80%, 70% alcohol solutions of various levels for 3-5 minutes each, and then put in distilled water for 3 minutes minute;

[0066] 4. Place the slices in antigen retrieval solution (Bosch, AR0024) and boil in microwave for 15 minutes, then cool naturally to room temperature;

[0067] 5. Soak the slice in TBST solution (1×TBS, 0.1% (volume percentage Tween 20)) for 2 minutes;

[0068] 6. Place the section in blocking solution (1×TBS, 0.1% Tween 20 (volume percentage), 5% BSA (mass percentage), and let stand at room temperature for 1 hour. ...

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Abstract

The invention discloses an application of CICs in breast tumor tissues in preparation of a product for predicting breast cancer prognosis survival. The invention provides an application of a substancefor detecting the number of oCICs in breast cancer tissues of a breast cancer patient in preparation of a product for predicting the prognosis survival rate of the breast cancer patient. The invention further provides application of the substance for detecting the number of TiT subtypes in breast cancer tissue of a breast cancer patient in preparation of the product for predicting the prognosis survival rate of the breast cancer patient. The invention further provides an application of the substance for detecting the MiT subtype number in breast cancer tissue of a breast cancer patient to preparation of a product for predicting the prognosis survival rate of the breast cancer patient. The invention also provides an application of the substance for detecting the number of TiM subtypes in breast cancer tissues of the breast cancer patient in preparing the product for predicting the prognosis survival rate of the breast cancer patient. Prognosis of breast cancer patients is predicted through a CICs subtype analysis and counting method, and remarkable originality is achieved.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to the application of CICs in breast tumor tissue in the preparation of products for predicting the prognosis and survival of breast cancer. Background technique [0002] Breast cancer is one of the major diseases that seriously endanger women's health. Breast cancer has significant heterogeneity, which is manifested in the diversification of tumor biological behavior, patient prognosis and response to treatment. The disease is at an early stage when most patients first see a doctor, and surgical resection is an important means of disease treatment. The relevant pathological information provided by postoperative pathology is an important basis for judging the prognosis of patients and formulating follow-up treatment plans. Although with the standardization of surgery and adjuvant therapy, the recurrence risk of breast cancer patients has been significantly reduced, but the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57415
Inventor 黄红艳孙强张鑫牛祖彪郑幽
Owner BEIJING SHIJITAN HOSPITAL CAPITAL MEDICAL UNIVERSTY
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