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Application of glycyrrhetinic acid to prevention and treatment of stem cell senescence

A technology of glycyrrhetinic acid and stem cells, which can be used in applications, extracellular fluid diseases, medical preparations containing active ingredients, etc., and can solve problems such as non-reporting

Pending Publication Date: 2020-10-13
宁波荷仁健康科技有限公司
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Problems solved by technology

The function of glycyrrhetinic acid found in the current research is mainly to inhibit inflammation, etc. However, whether glycyrrhetinic acid regulates the aging of hematopoietic stem cells and improves inflammatory aging through programmed genes has not yet been reported.

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  • Application of glycyrrhetinic acid to prevention and treatment of stem cell senescence
  • Application of glycyrrhetinic acid to prevention and treatment of stem cell senescence
  • Application of glycyrrhetinic acid to prevention and treatment of stem cell senescence

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Embodiment Construction

[0039] The present invention will be described in detail below with reference to the accompanying drawings and embodiments, which are to explain rather than limit the present invention.

[0040] Licorice is widely used in traditional Chinese medicine. In order to observe the effect of glycyrrhetic acid on stem cell aging, mouse senescent MEF cells were selected as the cell model. As an animal model, the aging mouse model is a commonly used model to simulate normal physiological aging in humans.

[0041] 1. To verify the functional regulation of glycyrrhetic acid glycyrrhetic acid in senescent cells in vitro.

[0042] We used a replicative cellular senescence model and a model of irradiation-induced cellular senescence, where β-gal galactosidase staining after glycyrrhetinic acid administration, as in Picture 1-1 As shown, the number of positively stained cells decreased, and the number of senescent cells decreased as shown in Figure 1-2. Quantitative PCR showed that RNA leve...

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Abstract

The invention discloses application of glycyrrhetinic acid to prevention and treatment of stem cell senescence. The glycyrrhetinic acid can regulate and control senescence of bone marrow hematopoieticstem cells from a gene level and improve functions of the senescent bone marrow stem cells. After the glycyrrhetinic acid is added into the senescent cells for culturing, galactosidase staining positive cells are reduced. In a mouse senescence model, spleen extramedullary hematopoiesis of senescent mice after the glycyrrhetinic acid is applied is relieved, and myeloid differentiation tendency ofbone marrow hematopoiesis is rescued. The glycyrrhetinic acid can regulate the senescent stem cells and improve inflammatory senescence through programmed control of the gene level, plays a role in preventing and treating senescence of the stem cells, and provides a new idea for clinical application of hematopoietic stem cell transplantation. The glycyrrhetinic acid can directly target an inflammatory factor IL-6, patients with novel coronavirus (2019-nCoV) outbreaking in 2019 accompany high-level IL-6, and effective drugs, pneumonia No.1 and Lianhua Qingwen Granule, at present both contain liquorice components, so that the glycyrrhetinic acid is expected to provide a reference for novel coronavirus treatment.

Description

technical field [0001] The invention relates to the technical field of application of monomer components of Chinese herbal medicines, in particular to the application of glycyrrhetic acid for preventing and treating stem cell senescence. Background technique [0002] Aging is accompanied by a progressive loss of physiological functions and is a major risk factor for human diseases including cancer, diabetes, cardiovascular disease and neurodegenerative diseases. According to the economic and social development report released by the National Bureau of Statistics on August 22, 2019, the proportion of China's population aged 65 and above reached 11.9%, the population aging degree continued to deepen, and China began to enter an aging society. The accelerated aging of the population will increase the pressure on social and public services, weaken the demographic dividend, and affect economic and social development. It is an important risk and challenge for the development of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A61K31/56A61P7/06A61P29/00A61P31/14
CPCA23L33/105A61K31/56A61P7/06A61P29/00A61P31/14A23V2002/00A23V2200/30A23V2250/21
Inventor 鞠振宇陈建新杨帆
Owner 宁波荷仁健康科技有限公司
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